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The aim of this study is to analyze the relationship between the electroencephalographic (EEG) activity and the<jats:italic>PICALM<\/jats:italic>and<jats:italic>CLU<\/jats:italic>alleles described as conferring risk or protective effects on AD patients and healthy controls. For this purpose, EEG activity was acquired from: 18 AD patients and 12 controls carrying risk alleles of both<jats:italic>PICALM<\/jats:italic>and<jats:italic>CLU<\/jats:italic>genes, and 35 AD patients and 12 controls carrying both protective alleles. Relative power (RP) in the conventional EEG frequency bands (delta, theta, alpha, beta, and gamma) was computed to quantify the brain activity at source level. In addition, spatial entropy (SE) was calculated in each band to characterize the regional distribution of the RP values throughout the brain. Statistically significant differences in global RP and SE at beta band (<jats:italic>p<\/jats:italic>-values &lt; 0.05, Mann\u2013Whitney<jats:italic>U<\/jats:italic>-test) were found between genotypes in the AD group. Furthermore, RP showed statistically significant differences in 58 cortical regions out of the 68 analyzed in AD. No statistically significant differences were found in the control group at any frequency band. Our results suggest that<jats:italic>PICALM<\/jats:italic>and<jats:italic>CLU<\/jats:italic>AD-inducing genotypes are involved in physiological processes related to disruption in beta power, which may be associated with physiological disturbances such as alterations in beta-amyloid and neurotransmitter metabolism.<\/jats:p>","DOI":"10.1038\/s41598-021-99589-y","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T10:09:16Z","timestamp":1634206156000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Influence of PICALM and CLU risk variants on beta EEG activity in Alzheimer\u2019s disease patients"],"prefix":"10.1038","volume":"11","author":[{"given":"Aar\u00f3n","family":"Maturana-Candelas","sequence":"first","affiliation":[]},{"given":"Carlos","family":"G\u00f3mez","sequence":"additional","affiliation":[]},{"given":"Jes\u00fas","family":"Poza","sequence":"additional","affiliation":[]},{"given":"V\u00edctor","family":"Rodr\u00edguez-Gonz\u00e1lez","sequence":"additional","affiliation":[]},{"given":"V\u00ecctor Guti\u00e9rrez-de","family":"Pablo","sequence":"additional","affiliation":[]},{"given":"Alexandra M.","family":"Lopes","sequence":"additional","affiliation":[]},{"given":"Nadia","family":"Pinto","sequence":"additional","affiliation":[]},{"given":"Roberto","family":"Hornero","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,10,14]]},"reference":[{"key":"99589_CR1","unstructured":"Alzheimer\u2019s disease international. 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