{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T06:50:45Z","timestamp":1771829445250,"version":"3.50.1"},"reference-count":103,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PID2019-105234RB-I00"],"award-info":[{"award-number":["PID2019-105234RB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010434","name":"\u201cla Caixa\u201d Foundation","doi-asserted-by":"publisher","award":["LCF\/PR\/HP17\/52190001"],"award-info":[{"award-number":["LCF\/PR\/HP17\/52190001"]}],"id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["EXPL\/NEU-NMC\/0671\/2012"],"award-info":[{"award-number":["EXPL\/NEU-NMC\/0671\/2012"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-028160"],"award-info":[{"award-number":["POCI-01-0145-FEDER-028160"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["M.Curie:Cycle4-2013-PT-07"],"award-info":[{"award-number":["M.Curie:Cycle4-2013-PT-07"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["CENTRO-01-0145-FEDER-000008"],"award-info":[{"award-number":["CENTRO-01-0145-FEDER-000008"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The molecular mechanisms underlying circuit re-wiring in the mature brain remains ill-defined. An eloquent example of adult circuit remodelling is the hippocampal mossy fiber (MF) sprouting found in diseases such as temporal lobe epilepsy. The molecular determinants underlying this retrograde re-wiring remain unclear. This may involve signaling system(s) controlling axon specification\/growth during neurodevelopment reactivated during epileptogenesis. Since adenosine A<jats:sub>2A<\/jats:sub> receptors (A<jats:sub>2A<\/jats:sub>R) control axon formation\/outgrowth and synapse stabilization during development, we now examined the contribution of A<jats:sub>2A<\/jats:sub>R to MF sprouting. A<jats:sub>2A<\/jats:sub>R blockade significantly attenuated status epilepticus(SE)-induced MF sprouting in a rat pilocarpine model. This involves A<jats:sub>2A<\/jats:sub>R located in dentate granule cells since their knockdown selectively in dentate granule cells reduced MF sprouting, most likely through the ability of A<jats:sub>2A<\/jats:sub>R to induce the formation\/outgrowth of abnormal secondary axons found in rat hippocampal neurons. These A<jats:sub>2A<\/jats:sub>R should be activated by extracellular ATP-derived adenosine since a similar prevention\/attenuation of SE-induced hippocampal MF sprouting was observed in CD73 knockout mice. These findings demonstrate that A<jats:sub>2A<\/jats:sub>R contribute to epilepsy-related MF sprouting, most likely through the reactivation of the ability of A<jats:sub>2A<\/jats:sub>R to control axon formation\/outgrowth observed during neurodevelopment. These results frame the CD73-A<jats:sub>2A<\/jats:sub>R axis as a regulator of circuit remodeling in the mature brain.<\/jats:p>","DOI":"10.1038\/s41598-022-18884-4","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T14:02:59Z","timestamp":1661781779000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Adenosine A2A receptors control synaptic remodeling in the adult brain"],"prefix":"10.1038","volume":"12","author":[{"given":"Xinli","family":"Xu","sequence":"first","affiliation":[]},{"given":"Rui O.","family":"Beleza","sequence":"additional","affiliation":[]},{"given":"Francisco Q.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"Sergio","family":"Valbuena","sequence":"additional","affiliation":[]},{"given":"Sofia","family":"Al\u00e7ada-Morais","sequence":"additional","affiliation":[]},{"given":"N\u00e9lio","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"Joana","family":"Magalh\u00e3es","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o M. M.","family":"Rocha","sequence":"additional","affiliation":[]},{"given":"Sofia","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"Ana S. G.","family":"Figueira","sequence":"additional","affiliation":[]},{"given":"Juan","family":"Lerma","sequence":"additional","affiliation":[]},{"given":"Rodrigo A.","family":"Cunha","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7631-743X","authenticated-orcid":false,"given":"Ricardo J.","family":"Rodrigues","sequence":"additional","affiliation":[]},{"given":"Joana M.","family":"Marques","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"issue":"2","key":"18884_CR1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0306-4522(85)90299-4","volume":"14","author":"Y Ben-Ari","year":"1985","unstructured":"Ben-Ari, Y. Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy. Neuroscience 14(2), 375\u2013403 (1985).","journal-title":"Neuroscience"},{"key":"18884_CR2","unstructured":"Buckmaster, P. Mossy Fiber Sprouting in the Dentate Gyrus. in Jasper's Basic Mechanisms of the Epilepsies (eds. Rogawski, M. A., Delgado-Escueta, A. V., Noebels, J. L., Avoli, M., & Olsen, R. W.) 479\u2013500. (National Center for Biotechnology Information, US, Bethesda, MD, 2012)."},{"issue":"4","key":"18884_CR3","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1523\/JNEUROSCI.05-04-01016.1985","volume":"5","author":"DL Tauck","year":"1985","unstructured":"Tauck, D. L. & Nadler, J. V. Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats. J. Neurosci. 5(4), 1016\u20131022 (1985).","journal-title":"J. Neurosci."},{"issue":"2","key":"18884_CR4","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/cne.903520404","volume":"352","author":"MM Okazaki","year":"1995","unstructured":"Okazaki, M. M., Evenson, D. A. & Nadler, J. V. Hippocampal mossy fiber sprouting and synapse formation after status epilepticus in rats: Visualization after retrograde transport of biocytin. J. Comp. Neurol. 352(2), 515\u2013534 (1995).","journal-title":"J. Comp. Neurol."},{"issue":"1","key":"18884_CR5","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0014-4886(03)00035-9","volume":"182","author":"AJGD Holtmaat","year":"2003","unstructured":"Holtmaat, A. J. G. D. et al. Transient downregulation of Sema3A mRNA in a rat model for temporal lobe epilepsy: A novel molecular event potentially contributing to mossy fiber sprouting. Exp. Neurol. 182(1), 142\u2013150 (2003).","journal-title":"Exp. Neurol."},{"issue":"1","key":"18884_CR6","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/brain\/awp266","volume":"133","author":"R Muramatsu","year":"2010","unstructured":"Muramatsu, R. et al. The ratio of \u201cdeleted in colorectal cancer\u201d to \u201cuncoordinated-5A\u201d netrin-1 receptors on the growth cone regulates mossy fibre directionality. Brain 133(1), 60\u201375 (2010).","journal-title":"Brain"},{"issue":"11","key":"18884_CR7","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1097\/WNR.0b013e3283632c08","volume":"24","author":"K Shibata","year":"2013","unstructured":"Shibata, K. et al. Repulsive guidance molecule a regulates hippocampal mossy fiber branching in vitro. NeuroReport 24(11), 609\u2013615 (2013).","journal-title":"NeuroReport"},{"key":"18884_CR8","doi-asserted-by":"publisher","first-page":"382","DOI":"10.3389\/fneur.2018.00382","volume":"9","author":"R Koyama","year":"2018","unstructured":"Koyama, R. & Ikegawa, Y. The molecular and cellular mechanisms of axon guidance in mossy fiber sprouting. Front. Neurol. 9, 382. https:\/\/doi.org\/10.3389\/fneur.2018.00382 (2018).","journal-title":"Front. Neurol."},{"issue":"33","key":"18884_CR9","doi-asserted-by":"crossref","first-page":"7215","DOI":"10.1523\/JNEUROSCI.2045-04.2004","volume":"24","author":"R Koyama","year":"2004","unstructured":"Koyama, R. et al. Brain-derived neurotrophic factor induces hyperexcitable reentrant circuits in the dentate gyrus. J. Neurosci. 24(33), 7215\u20137224 (2004).","journal-title":"J. Neurosci."},{"issue":"22","key":"18884_CR10","doi-asserted-by":"crossref","first-page":"9754","DOI":"10.1523\/JNEUROSCI.22-22-09754.2002","volume":"22","author":"SC Danzer","year":"2002","unstructured":"Danzer, S. C., Crooks, K. R., Lo, D. C. & McNamara, J. O. Increased expression of brain-derived neurotrophic factor induces formation of basal dendrites and axonal branching in dentate granule cells in hippocampal explant cultures. J. Neurosci. 22(22), 9754\u20139763 (2002).","journal-title":"J. Neurosci."},{"issue":"2","key":"18884_CR11","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1006\/exnr.2002.7869","volume":"174","author":"HE Scharfman","year":"2002","unstructured":"Scharfman, H. E., Goodman, J. H., Sollas, A. L. & Croll, S. D. Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor. Exp. Neurol. 174(2), 201\u2013214 (2002).","journal-title":"Exp. Neurol."},{"issue":"3","key":"18884_CR12","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s002210050413","volume":"120","author":"R Bender","year":"1998","unstructured":"Bender, R., Heimrich, B., Meyer, M. & Frotscher, M. Hippocampal mossy fiber sprouting is not impaired in brain-derived neurotrophic factor-deficient mice. Exp. Brain. Res. 120(3), 399\u2013402 (1998).","journal-title":"Exp. Brain. Res."},{"issue":"1","key":"18884_CR13","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0306-4522(98)00289-9","volume":"89","author":"VA Vaidya","year":"1999","unstructured":"Vaidya, V. A., Siuciak, J. A., Du, F. & Duman, R. S. Hippocampal mossy fiber sprouting induced by chronic electroconvulsive seizures. Neuroscience 89(1), 157\u2013166 (1999).","journal-title":"Neuroscience"},{"issue":"3","key":"18884_CR14","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/jnr.1075","volume":"64","author":"X Qiao","year":"2001","unstructured":"Qiao, X., Suri, C., Knusel, B. & Noebels, J. L. Absence of hippocampal mossy fiber sprouting in transgenic mice overexpressing brain-derived neurotrophic factor. J. Neurosci. Res. 64(3), 268\u2013276 (2001).","journal-title":"J. Neurosci. Res."},{"issue":"2","key":"18884_CR15","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1523\/JNEUROSCI.19-02-00802.1999","volume":"19","author":"Y Ikegaya","year":"1999","unstructured":"Ikegaya, Y. Abnormal targeting of developing hippocampal mossy fibers after epileptiform activities via L-type Ca2+ channel activation in vitro. J. Neurosci. 19(2), 802\u2013812 (1999).","journal-title":"J. Neurosci."},{"issue":"6","key":"18884_CR16","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1111\/jnc.13724","volume":"139","author":"RA Cunha","year":"2016","unstructured":"Cunha, R. A. How does adenosine control neuronal dysfunction and neurodegeneration?. J. Neurochem. 139(6), 1019\u20131055 (2016).","journal-title":"J. Neurochem."},{"issue":"5","key":"18884_CR17","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1046\/j.1471-4159.1996.67052180.x","volume":"67","author":"RA Cunha","year":"1996","unstructured":"Cunha, R. A., Vizi, E. S., Ribeiro, J. A. & Sebasti\u00e3o, A. M. Preferential release of ATP and its extracellular catabolism as a source of adenosine upon high- but not low-frequency stimulation of rat hippocampal slices. J. Neurochem. 67(5), 2180\u20132187 (1996).","journal-title":"J. Neurochem."},{"issue":"1","key":"18884_CR18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neuron.2007.11.023","volume":"57","author":"N Rebola","year":"2008","unstructured":"Rebola, N., Lujan, R., Cunha, R. A. & Mulle, C. Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses. Neuron 57(1), 121\u2013134 (2008).","journal-title":"Neuron"},{"issue":"12","key":"18884_CR19","doi-asserted-by":"crossref","first-page":"5652","DOI":"10.1093\/cercor\/bhab188","volume":"31","author":"S Al\u00e7ada-Morais","year":"2021","unstructured":"Al\u00e7ada-Morais, S. et al. Adenosine A2A receptors contribute to the radial migration of cortical projection neurons through the regulation of neuronal polarization and axon formation. Cereb. Cortex. 31(12), 5652\u20135663 (2021).","journal-title":"Cereb. Cortex."},{"issue":"6568","key":"18884_CR20","doi-asserted-by":"crossref","first-page":"eabk2055","DOI":"10.1126\/science.abk2055","volume":"374","author":"F Gomez-Castro","year":"2021","unstructured":"Gomez-Castro, F. et al. Convergence of adenosine and GABA signaling for synapse stabilization during development. Science 374(6568), eabk2055 (2021).","journal-title":"Science"},{"key":"18884_CR21","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.neuropharm.2012.12.002","volume":"67","author":"G Maraula","year":"2013","unstructured":"Maraula, G. et al. Effects of oxygen and glucose deprivation on synaptic transmission in rat dentate gyrus: Role of A2A adenosine receptors. Neuropharmacology 67, 511\u2013520 (2013).","journal-title":"Neuropharmacology"},{"key":"18884_CR22","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1528-1167.2005.01026.x","volume":"46","author":"N Rebola","year":"2005","unstructured":"Rebola, N. et al. Long-term effect of convulsive behavior on the density of adenosine A1 and A2A receptors in the rat cerebral cortex. Epilepsia 46, 159\u2013165 (2005).","journal-title":"Epilepsia"},{"issue":"6","key":"18884_CR23","doi-asserted-by":"publisher","first-page":"eneuro0385-18","DOI":"10.1523\/eneuro.0385-18.2018","volume":"5","author":"PM Canas","year":"2018","unstructured":"Canas, P. M. et al. Neuronal adenosine A2A receptors are critical mediators of neurodegeneration triggered by convulsions. eNeuro 5(6), eneuro0385-18. https:\/\/doi.org\/10.1523\/eneuro.0385-18.2018 (2018).","journal-title":"eNeuro"},{"key":"18884_CR24","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105441","volume":"157","author":"E Augusto","year":"2021","unstructured":"Augusto, E. et al. Increased ATP release and CD73-mediated adenosine A2A receptor activation mediate convulsion-associated neuronal damage and hippocampal dysfunction. Neurobiol. Dis. 157, 105441 (2021).","journal-title":"Neurobiol. Dis."},{"issue":"3","key":"18884_CR25","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00210-009-0426-8","volume":"380","author":"M El Yacoubi","year":"2009","unstructured":"El Yacoubi, M., Ledent, C., Parmentier, M., Costentin, J. & Vaugeois, J. M. Adenosine A2A receptor deficient mice are partially resistant to limbic seizures. Naunyn Schmiedebergs Arch. Pharmacol. 380(3), 223\u2013232 (2009).","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"issue":"3","key":"18884_CR26","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/cne.902280310","volume":"228","author":"J Zimmer","year":"1984","unstructured":"Zimmer, J. & Gahwiler, B. H. Cellular and connective organization of slice cultures of the rat hippocampus and fascia dentata. J. Comp. Neurol. 228(3), 432\u2013446 (1984).","journal-title":"J. Comp. Neurol."},{"issue":"2","key":"18884_CR27","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/cne.903620205","volume":"362","author":"BW Coltman","year":"1995","unstructured":"Coltman, B. W., Earley, E. M., Shahar, A., Dudek, F. E. & Ide, C. F. Factors influencing mossy fiber collateral sprouting in organotypic slice cultures of neonatal mouse hippocampus. J. Comp. Neurol. 362(2), 209\u2013222 (1995).","journal-title":"J. Comp. Neurol."},{"issue":"1","key":"18884_CR28","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ijdevneu.2004.08.003","volume":"23","author":"MM Lindroos","year":"2005","unstructured":"Lindroos, M. M. et al. Maturation of cultured hippocampal slices results in increased excitability in granule cells. Int. J. Dev. Neurosci. 23(1), 65\u201373 (2005).","journal-title":"Int. J. Dev. Neurosci."},{"issue":"6","key":"18884_CR29","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1152\/jn.2000.84.6.2918","volume":"84","author":"SB Bausch","year":"2000","unstructured":"Bausch, S. B. & McNamara, J. O. Synaptic connections from multiple subfields contribute to granule cell hyperexcitability in hippocampal slice cultures. J. Neurophysiol. 84(6), 2918\u20132932 (2000).","journal-title":"J. Neurophysiol."},{"issue":"6","key":"18884_CR30","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/j.1528-1157.1993.tb02123.x","volume":"34","author":"LE Mello","year":"1993","unstructured":"Mello, L. E. et al. Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: Cell loss and mossy fiber sprouting. Epilepsia 34(6), 985\u2013995 (1993).","journal-title":"Epilepsia"},{"issue":"12","key":"18884_CR31","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1038\/npp.2016.98","volume":"41","author":"AP Sim\u00f5es","year":"2016","unstructured":"Sim\u00f5es, A. P. et al. Adenosine A2A receptors in the amygdala control synaptic plasticity and contextual fear memory. Neuropsychopharmacology 41(12), 2862\u20132871 (2016).","journal-title":"Neuropsychopharmacology"},{"key":"18884_CR32","doi-asserted-by":"publisher","first-page":"11915","DOI":"10.1038\/ncomms11915","volume":"7","author":"S Viana da Silva","year":"2016","unstructured":"Viana da Silva, S. et al. Early synaptic deficits in the APP\/PS1 mouse model of Alzheimer\u2019s disease involve neuronal adenosine A2A receptors. Nat. Commun. 7, 11915. https:\/\/doi.org\/10.1038\/ncomms11915 (2016).","journal-title":"Nat. Commun."},{"issue":"11","key":"18884_CR33","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1111\/j.1460-9568.1994.tb00569.x","volume":"6","author":"D Grabs","year":"1994","unstructured":"Grabs, D. et al. Differential expression of synaptophysin and synaptoporin during pre- and postnatal development of the rat hippocampal network. Eur. J. Neurosci. 6(11), 1765\u20131771 (1994).","journal-title":"Eur. J. Neurosci."},{"issue":"2","key":"18884_CR34","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.celrep.2014.06.032","volume":"8","author":"A Peret","year":"2011","unstructured":"Peret, A. et al. Contribution of aberrant GluK2-containing kainate receptors to chronic seizures in temporal lobe epilepsy. Cell Rep. 8(2), 347\u2013354 (2011).","journal-title":"Cell Rep."},{"key":"18884_CR35","doi-asserted-by":"publisher","first-page":"413","DOI":"10.3389\/fncel.2015.00413","volume":"9","author":"N Kourdougli","year":"2015","unstructured":"Kourdougli, N., Varpula, S., Chazal, G. & Rivera, C. Detrimental effect of post Status Epilepticus treatment with ROCK inhibitor Y-27632 in a pilocarpine model of temporal lobe epilepsy. Front. Cell. Neurosci. 9, 413. https:\/\/doi.org\/10.3389\/fncel.2015.00413 (2015).","journal-title":"Front. Cell. Neurosci."},{"issue":"6","key":"18884_CR36","doi-asserted-by":"crossref","first-page":"461","DOI":"10.2174\/156652308786847996","volume":"8","author":"C Lundberg","year":"2008","unstructured":"Lundberg, C. et al. Applications of lentiviral vectors for biology and gene therapy of neurological disorders. Curr. Gene. Ther. 8(6), 461\u2013473 (2008).","journal-title":"Curr. Gene. Ther."},{"issue":"11","key":"18884_CR37","doi-asserted-by":"crossref","first-page":"4508","DOI":"10.1523\/JNEUROSCI.19-11-04508.1999","volume":"19","author":"JM Parent","year":"1999","unstructured":"Parent, J. M., Tada, E., Fike, J. R. & Lowenstein, D. H. Inhibition of dentate granule cell neurogenesis with brain irradiation does not prevent seizure-induced mossy fiber synaptic reorganization in the rat. J. Neurosci. 19(11), 4508\u20134519 (1999).","journal-title":"J. Neurosci."},{"issue":"10","key":"18884_CR38","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1523\/JNEUROSCI.17-10-03727.1997","volume":"17","author":"JM Parent","year":"1997","unstructured":"Parent, J. M. et al. Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. J. Neurosci. 17(10), 3727\u20133738 (1997).","journal-title":"J. Neurosci."},{"issue":"1","key":"18884_CR39","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ana.20699","volume":"59","author":"JM Parent","year":"2006","unstructured":"Parent, J. M., Elliott, R. C., Pleasure, S. J., Barbaro, N. M. & Lowenstein, D. H. Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy. Ann. Neurol. 59(1), 81\u201391 (2006).","journal-title":"Ann. Neurol."},{"issue":"35","key":"18884_CR40","doi-asserted-by":"crossref","first-page":"9400","DOI":"10.1523\/JNEUROSCI.2002-07.2007","volume":"27","author":"S Jessberger","year":"2007","unstructured":"Jessberger, S. et al. Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling. J. Neurosci. 27(35), 9400\u20139407 (2007).","journal-title":"J. Neurosci."},{"issue":"6","key":"18884_CR41","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1523\/JNEUROSCI.5655-09.2010","volume":"30","author":"MM Kron","year":"2010","unstructured":"Kron, M. M., Zhang, H. & Parent, J. M. The developmental stage of dentate granule cells dictates their contribution to seizure-induced plasticity. J. Neurosci. 30(6), 2051\u20132059 (2010).","journal-title":"J. Neurosci."},{"key":"18884_CR42","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.nbd.2015.11.024","volume":"86","author":"AL Althaus","year":"2016","unstructured":"Althaus, A. L., Zhang, H. & Parent, J. M. Axonal plasticity of age-defined dentate granule cells in a rat model of mesial temporal lobe epilepsy. Neurobiol. Dis. 86, 187\u2013196 (2016).","journal-title":"Neurobiol. Dis."},{"key":"18884_CR43","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.brainresbull.2019.02.006","volume":"147","author":"M Shukla","year":"2019","unstructured":"Shukla, M. et al. Attenuation of adverse effects of noise induced hearing loss on adult neurogenesis and memory in rats by intervention with adenosine A2A receptor agonist. Brain Res. Bull. 147, 47\u201357 (2019).","journal-title":"Brain Res. Bull."},{"issue":"4","key":"18884_CR44","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1089\/caff.2019.0010","volume":"9","author":"JM Mateus","year":"2019","unstructured":"Mateus, J. M. et al. Neurogenesis and gliogenesis: Relevance of adenosine for neuroregeneration in brain disorders. J. Caffeine Adenosine Res. 9(4), 129\u2013144 (2019).","journal-title":"J. Caffeine Adenosine Res."},{"issue":"46","key":"18884_CR45","doi-asserted-by":"crossref","first-page":"14484","DOI":"10.1523\/JNEUROSCI.1768-09.2009","volume":"29","author":"JS Snyder","year":"2009","unstructured":"Snyder, J. S. et al. Adult born hippocampal neurons are more numerous, faster maturing, and more involved in behavior in rats than in mice. J. Neurosci. 29(46), 14484\u201314495 (2009).","journal-title":"J. Neurosci."},{"key":"18884_CR46","doi-asserted-by":"publisher","first-page":"6514","DOI":"10.1038\/ncomms7514","volume":"6","author":"T Matsuda","year":"2015","unstructured":"Matsuda, T. et al. TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus. Nat. Commun. 6, 6514. https:\/\/doi.org\/10.1038\/ncomms7514 (2015).","journal-title":"Nat. Commun."},{"issue":"2","key":"18884_CR47","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1242\/dev.00203","volume":"130","author":"G Kempermann","year":"2003","unstructured":"Kempermann, G., Gast, D., Kronenberg, G., Yamaguchi, M. & Gage, F. H. Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice. Development 130(2), 391\u2013399 (2003).","journal-title":"Development"},{"issue":"4","key":"18884_CR48","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","volume":"70","author":"GL Ming","year":"2011","unstructured":"Ming, G. L. & Song, H. J. Adult neurogenesis in the mammalian brain: Significant answers and significant questions. Neuron 70(4), 687\u2013702 (2011).","journal-title":"Neuron"},{"issue":"2","key":"18884_CR49","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0306-4522(99)00135-9","volume":"93","author":"SW Schoen","year":"1999","unstructured":"Schoen, S. W., Ebert, U. & Loscher, W. 5 \u2019-nucleotidase activity of mossy fibers in the dentate gyrus of normal and epileptic rats. Neuroscience 93(2), 519\u2013526 (1999).","journal-title":"Neuroscience"},{"issue":"3","key":"18884_CR50","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0920-1211(00)00095-4","volume":"39","author":"CD Bonan","year":"2000","unstructured":"Bonan, C. D. et al. Changes in synaptosomal ectonucleotidase activities in two rat models of temporal lobe epilepsy. Epilepsy Res. 39(3), 229\u2013238 (2000).","journal-title":"Epilepsy Res."},{"issue":"5","key":"18884_CR51","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/00005072-199905000-00004","volume":"58","author":"AA Lie","year":"1999","unstructured":"Lie, A. A. et al. 5\u2019-nucleotidase activity indicates sites of synaptic plasticity and reactive synaptogenesis in the human brain. J. Neuropathol. Exp. Neurol. 58(5), 451\u2013458 (1999).","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"2","key":"18884_CR52","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1212\/WNL.58.2.265","volume":"58","author":"R Briellmann","year":"2002","unstructured":"Briellmann, R., Kalnins, R., Berkovic, S. & Jackson, G. Hippocampal pathology in refractory temporal lobe epilepsy: T2-weighted signal change reflects dentate gliosis. Neurology 58(2), 265\u2013271 (2002).","journal-title":"Neurology"},{"issue":"6","key":"18884_CR53","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1093\/jnen\/61.6.510","volume":"61","author":"M Thom","year":"2002","unstructured":"Thom, M. et al. Cytoarchitectural abnormalities in hippocampal sclerosis. J. Neuropathol. Exp. Neurol. 61(6), 510\u2013519 (2002).","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"1","key":"18884_CR54","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0920-1211(96)00051-4","volume":"26","author":"M Khurgel","year":"1996","unstructured":"Khurgel, M. & Ivy, G. Astrocytes in kindling: Relevance to epileptogenesis. Epilepsy Res. 26(1), 163\u2013175 (1996).","journal-title":"Epilepsy Res."},{"issue":"11","key":"18884_CR55","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1002\/glia.23169","volume":"65","author":"S Kim","year":"2017","unstructured":"Kim, S., Nabekura, J. & Koizumi, S. Astrocyte-mediated synapse remodeling in the pathological brain. Glia 65(11), 1719\u20131727 (2017).","journal-title":"Glia"},{"issue":"5","key":"18884_CR56","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1007\/s00429-015-1072-1","volume":"221","author":"FF Ribeiro","year":"2016","unstructured":"Ribeiro, F. F. et al. Axonal elongation and dendritic branching is enhanced by adenosine A2A receptors activation in cerebral cortical neurons. Brain Struct. Funct. 221(5), 2777\u20132799 (2016).","journal-title":"Brain Struct. Funct."},{"issue":"3","key":"18884_CR57","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/hipo.10089","volume":"13","author":"RA Bender","year":"2003","unstructured":"Bender, R. A., Dube, C., Gonzalez-Vega, R., Mina, E. W. & Baram, T. Z. Mossy fiber plasticity and enhanced hippocampal excitability, without hippocampal cell loss or altered neurogenesis, in an animal model of prolonged febrile seizures. Hippocampus 13(3), 399\u2013412 (2003).","journal-title":"Hippocampus"},{"issue":"4784","key":"18884_CR58","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1126\/science.2879352","volume":"235","author":"RS Sloviter","year":"1987","unstructured":"Sloviter, R. S. Decreased hippocampal inhibition and a selective loss of interneurons in experimental epilepsy. Science 235(4784), 73\u201376 (1987).","journal-title":"Science"},{"issue":"2","key":"18884_CR59","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0006-8993(90)91601-C","volume":"535","author":"CR Houser","year":"1990","unstructured":"Houser, C. R. Granule cell dispersion in the dentate gyrus of humans with temporal lobe epilepsy. Brain Res. 535(2), 195\u2013204 (1990).","journal-title":"Brain Res."},{"issue":"2","key":"18884_CR60","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0306-4522(91)90380-7","volume":"42","author":"TL Babb","year":"1991","unstructured":"Babb, T. L., Kupfer, W. R., Pretorius, J. K., Crandall, P. H. & Levesque, M. F. Synaptic reorganization by mossy fibers in human epileptic fascia dentata. Neuroscience 42(2), 351\u2013363 (1991).","journal-title":"Neuroscience"},{"issue":"1","key":"18884_CR61","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0006-8993(92)90750-4","volume":"579","author":"LM Masukawa","year":"1992","unstructured":"Masukawa, L. M., Uruno, K., Sperling, M., O\u2019Connor, M. J. & Burdette, L. J. The functional relationship between antidromically evoked field responses of the dentate gyrus and mossy fiber reorganization in temporal lobe epileptic patients. Brain Res. 579(1), 119\u2013127 (1992).","journal-title":"Brain Res."},{"issue":"1","key":"18884_CR62","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0014-4886(02)00046-8","volume":"181","author":"BM Longo","year":"2003","unstructured":"Longo, B. M., Covolan, L., Chadi, G. & Mello, L. E. A. M. Sprouting of mossy fibers and the vacating of postsynaptic targets in the inner molecular layer of the dentate gyrus. Exp. Neurol. 181(1), 57\u201367 (2003).","journal-title":"Exp. Neurol."},{"issue":"2","key":"18884_CR63","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.expneurol.2005.08.007","volume":"196","author":"JP Pierce","year":"2005","unstructured":"Pierce, J. P., Melton, J., Punsoni, M., McCloskey, D. P. & Scharfman, H. E. Mossy fibers are the primary source of afferent input to ectopic granule cells that are born after pilocarpine-induced seizures. Exp. Neurol. 196(2), 316\u2013331 (2005).","journal-title":"Exp. Neurol."},{"key":"18884_CR64","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.eplepsyres.2017.08.002","volume":"136","author":"B Schmeiser","year":"2017","unstructured":"Schmeiser, B. et al. Different mossy fiber sprouting patterns in ILAE hippocampal sclerosis types. Epilepsy Res. 136, 115\u2013122 (2017).","journal-title":"Epilepsy Res."},{"issue":"1","key":"18884_CR65","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/(SICI)1096-9861(19991011)413:1<146::AID-CNE10>3.0.CO;2-B","volume":"413","author":"NB Hastings","year":"1999","unstructured":"Hastings, N. B. & Gould, E. Rapid extension of axons into the CA3 region by adult-generated granule cells. J. Comp. Neurol. 413(1), 146\u2013154 (1999).","journal-title":"J. Comp. Neurol."},{"issue":"8","key":"18884_CR66","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/nn.2156","volume":"11","author":"N Toni","year":"2008","unstructured":"Toni, N. et al. Neurons born in the adult dentate gyrus form functional synapses with target cells. Nat. Neurosci. 11(8), 901\u2013907 (2008).","journal-title":"Nat. Neurosci."},{"key":"18884_CR67","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2019.104570","volume":"132","author":"FQ Gon\u00e7alves","year":"2019","unstructured":"Gon\u00e7alves, F. Q. et al. Synaptic and memory dysfunction in a beta-amyloid model of early Alzheimer\u2019s disease depends on increased formation of ATP-derived extracellular adenosine. Neurobiol. Dis. 132, 104570 (2019).","journal-title":"Neurobiol. Dis."},{"issue":"18","key":"18884_CR68","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1111\/bph.14771","volume":"176","author":"M Carmo","year":"2019","unstructured":"Carmo, M. et al. Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A2A receptor over-activation in a rat model of Parkinson\u2019s disease. Br. J. Pharmacol. 176(18), 3666\u20133680 (2019).","journal-title":"Br. J. Pharmacol."},{"issue":"47","key":"18884_CR69","doi-asserted-by":"crossref","first-page":"14741","DOI":"10.1523\/JNEUROSCI.3728-09.2009","volume":"29","author":"PM Canas","year":"2009","unstructured":"Canas, P. M. et al. Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38mitogen-activated protein kinase pathway. J. Neurosci. 29(47), 14741\u201314751 (2009).","journal-title":"J. Neurosci."},{"issue":"12","key":"18884_CR70","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1523\/JNEUROSCI.4454-03.2004","volume":"24","author":"MJ Di\u00f3genes","year":"2004","unstructured":"Di\u00f3genes, M. J., Fernandes, C. C., Sebasti\u00e3o, A. M. & Ribeiro, J. A. Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic transmission in hippocampal slices. J. Neurosci. 24(12), 2905\u20132913 (2004).","journal-title":"J. Neurosci."},{"issue":"2","key":"18884_CR71","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1006\/exnr.1997.6737","volume":"149","author":"JS Rudge","year":"1998","unstructured":"Rudge, J. S. et al. Endogenous BDNF protein is increased in adult rat hippocampus after a kainic acid induced excitotoxic insult but exogenous BDNF is not neuroprotective. Exp. Neurol. 149(2), 398\u2013410 (1998).","journal-title":"Exp. Neurol."},{"issue":"6","key":"18884_CR72","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1139\/y74-162","volume":"52","author":"JW Phillis","year":"1974","unstructured":"Phillis, J. W., Kostopoulos, G. K. & Limacher, J. J. Depression of corticospinal cells by various purines and pyrimidines. Can. J. Physiol. Pharmacol. 52(6), 1226\u20131229 (1974).","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"1","key":"18884_CR73","first-page":"70","volume":"220","author":"TV Dunwiddie","year":"1982","unstructured":"Dunwiddie, T. V. & Worth, T. Sedative and anticonvulsant effects of adenosine analogs in mouse and rat. J. Pharmacol. Exp. Ther. 220(1), 70\u201376 (1982).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"18884_CR74","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev.neuro.24.1.31","volume":"24","author":"TV Dunwiddie","year":"2001","unstructured":"Dunwiddie, T. V. & Masino, S. A. The role and regulation of adenosine in the central nervous system. Annu. Rev. Neurosci. 24, 31\u201355 (2001).","journal-title":"Annu. Rev. Neurosci."},{"issue":"2","key":"18884_CR75","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1089\/caff.2019.0022","volume":"10","author":"FC Tescarollo","year":"2020","unstructured":"Tescarollo, F. C. et al. Role of adenosine in epilepsy and seizures. J. Caffeine Adenosine Res. 10(2), 45\u201360 (2020).","journal-title":"J. Caffeine Adenosine Res."},{"key":"18884_CR76","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2021.102105","volume":"204","author":"E Beamer","year":"2021","unstructured":"Beamer, E., Kuchukulla, M., Boison, D. & Engel, T. ATP and adenosine\u2014Two players in the control of seizures and epilepsy development. Prog. Neurobiol. 204, 101105. https:\/\/doi.org\/10.1016\/j.pneurobio.2021.102105 (2021).","journal-title":"Prog. Neurobiol."},{"key":"18884_CR77","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/j.1460-9568.2009.06897.x","volume":"30","author":"I D\u2019Alimonte","year":"2009","unstructured":"D\u2019Alimonte, I. et al. Altered distribution and function of A2A adenosine receptors in the brain of WAG\/Rij rats with genetic absence epilepsy, before and after appearance of the disease. Eur. J. Neurosci. 30, 1023\u20131035 (2009).","journal-title":"Eur. J. Neurosci."},{"key":"18884_CR78","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.yebeh.2018.06.048","volume":"86","author":"M Crespo","year":"2018","unstructured":"Crespo, M., Leon-Navarro, D. A. & Martin, M. Early-life hyperthermic seizures upregulate adenosine A2A receptors in the cortex and promote depressive-like behavior in adult rats. Epilepsy Behav. 86, 173\u2013178 (2018).","journal-title":"Epilepsy Behav."},{"issue":"4","key":"18884_CR79","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s11302-016-9535-2","volume":"12","author":"AR Barros-Barbosa","year":"2016","unstructured":"Barros-Barbosa, A. R. et al. Adenosine A2A receptor and ecto-5\u2019-nucleotidase\/CD73 are upregulated in hippocampal astrocytes of human patients with mesial temporal lobe epilepsy (MTLE). Purinergic Signal 12(4), 719\u2013734 (2016).","journal-title":"Purinergic Signal"},{"issue":"3","key":"18884_CR80","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0304-3940(89)90178-X","volume":"106","author":"A Wieraszko","year":"1989","unstructured":"Wieraszko, A. & Seyfried, T. N. Increased amount of extracellular ATP in stimulated hippocampal slices of seizure prone mice. Neurosci. Lett. 106(3), 287\u2013293 (1989).","journal-title":"Neurosci. Lett."},{"issue":"2","key":"18884_CR81","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s11302-016-9504-9","volume":"12","author":"F Dona","year":"2016","unstructured":"Dona, F. et al. Variations of ATP and its metabolites in the hippocampus of rats subjected to pilocarpine-induced temporal lobe epilepsy. Purinergic Signal 12(2), 295\u2013302 (2016).","journal-title":"Purinergic Signal"},{"key":"18884_CR82","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.brainresbull.2018.12.021","volume":"151","author":"E Beamer","year":"2019","unstructured":"Beamer, E., Conte, G. & Engel, T. ATP release during seizures - a critical evaluation of the evidence. Brain Res. Bull. 151, 65\u201373 (2019).","journal-title":"Brain Res. Bull."},{"issue":"1","key":"18884_CR83","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.seizure.2005.10.006","volume":"15","author":"M Zeraati","year":"2006","unstructured":"Zeraati, M., Mirnajafi-Zadeh, J., Fathollahi, Y., Namvar, S. & Rezvani, M. E. Adenosine A1 and A2A receptors of hippocampal CA1 region have opposite effects on piriform cortex kindled seizures in rats. Seizure 15(1), 41\u201348 (2006).","journal-title":"Seizure"},{"issue":"2","key":"18884_CR84","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.phrs.2007.04.011","volume":"56","author":"N Hosseinmardi","year":"2007","unstructured":"Hosseinmardi, N., Mirnajafi-Zadeh, J., Fathollahi, Y. & Shahabi, P. The role of adenosine A1 and A2A receptors of entorhinal cortex on piriform cortex kindled seizures in rats. Pharmacol. Res. 56(2), 110\u2013117 (2007).","journal-title":"Pharmacol. Res."},{"issue":"1","key":"18884_CR85","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuropharm.2008.04.007","volume":"55","author":"M El Yacoubi","year":"2008","unstructured":"El Yacoubi, M., Ledent, C., Parmentier, M., Costentin, J. & Vaugeois, J. M. Evidence for the involvement of the adenosine A2A receptor in the lowered susceptibility to pentylenetetrazol-induced seizures produced in mice by long-term treatment with caffeine. Neuropharmacology 55(1), 35\u201340 (2008).","journal-title":"Neuropharmacology"},{"issue":"2","key":"18884_CR86","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s11596-012-0046-2","volume":"32","author":"X Li","year":"2012","unstructured":"Li, X. et al. Effect of adenosine A2A receptor antagonist ZM241385 on amygdala-kindled seizures and progression of amygdala kindling. J. Huazhong Univ. Sci. Technol. Med. Sci 32(2), 257\u2013264 (2012).","journal-title":"J. Huazhong Univ. Sci. Technol. Med. Sci"},{"issue":"2","key":"18884_CR87","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1471-4159.2009.06465.x","volume":"112","author":"GP Cognato","year":"2010","unstructured":"Cognato, G. P. et al. Caffeine and an adenosine A2A receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life. J. Neurochem. 112(2), 453\u2013462 (2010).","journal-title":"J. Neurochem."},{"issue":"15","key":"18884_CR88","doi-asserted-by":"crossref","first-page":"6650","DOI":"10.1523\/JNEUROSCI.22-15-06650.2002","volume":"22","author":"PS Buckmaster","year":"2002","unstructured":"Buckmaster, P. S., Zhang, G. F. & Yamawaki, R. Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuit. J. Neurosci. 22(15), 6650\u20136658 (2002).","journal-title":"J. Neurosci."},{"issue":"3","key":"18884_CR89","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/cne.10581","volume":"458","author":"JE Cavazos","year":"2003","unstructured":"Cavazos, J. E., Zhang, P., Qazi, R. & Sutula, T. P. Ultrastructural features of sprouted mossy fiber synapses in kindled and kainic acid-treated rats. J. Comp. Neurol. 458(3), 272\u2013292 (2003).","journal-title":"J. Comp. Neurol."},{"issue":"36","key":"18884_CR90","doi-asserted-by":"crossref","first-page":"8229","DOI":"10.1523\/JNEUROSCI.1469-05.2005","volume":"25","author":"J Epsztein","year":"2005","unstructured":"Epsztein, J., Represa, A., Jorquera, I., Ben-Ari, Y. & Cr\u00e9pel, V. Recurrent mossy fibers establish aberrant kainate receptor-operated synapses on granule cells from epileptic rats. J. Neurosci. 25(36), 8229\u20138239 (2005).","journal-title":"J. Neurosci."},{"issue":"4","key":"18884_CR91","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/ana.24348","volume":"77","author":"J Artinian","year":"2015","unstructured":"Artinian, J., Peret, A., Mircheva, Y., Marti, G. & Cr\u00e9pel, V. Impaired neuronal operation through aberrant intrinsic plasticity in epilepsy. Ann. Neurol. 77(4), 592\u2013606 (2015).","journal-title":"Ann. Neurol."},{"issue":"22","key":"18884_CR92","doi-asserted-by":"crossref","first-page":"10994","DOI":"10.1073\/pnas.1821227116","volume":"116","author":"WD Hendricks","year":"2019","unstructured":"Hendricks, W. D., Westbrook, G. L. & Schnell, E. Early detonation by sprouted mossy fibers enables aberrant dentate network activity. Proc. Natl. Acad. Sci. USA 116(22), 10994\u201310999 (2019).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"18884_CR93","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.3389\/fneur.2018.01023","volume":"9","author":"CF Cavarsan","year":"2018","unstructured":"Cavarsan, C. F., Malheiros, J., Hamani, C., Najm, I. & Covolan, L. Is mossy fiber sprouting a potential therapeutic target for epilepsy?. Front. Neurol. 9, 1023. https:\/\/doi.org\/10.3389\/fneur.2018.01023 (2018).","journal-title":"Front. Neurol."},{"issue":"3","key":"18884_CR94","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.psychres.2011.06.005","volume":"195","author":"L Kandratavicius","year":"2012","unstructured":"Kandratavicius, L. et al. Differential aberrant sprouting in temporal lobe epilepsy with psychiatric co-morbidities. Psychiatry Res. 195(3), 144\u2013150 (2012).","journal-title":"Psychiatry Res."},{"issue":"11","key":"18884_CR95","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1084\/jem.20040915","volume":"200","author":"LF Thompson","year":"2004","unstructured":"Thompson, L. F. et al. Crucial role for ecto-5\u2019-nucleotidase (CD73) in vascular leakage during hypoxia. J. Exp. Med. 200(11), 1395\u20131405 (2004).","journal-title":"J. Exp. Med."},{"issue":"2","key":"18884_CR96","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0165-0270(91)90128-M","volume":"37","author":"L Stoppini","year":"1991","unstructured":"Stoppini, L., Buchs, P. A. & Muller, D. A simple method for organotypic cultures of nervous tissue. J. Neurosci. Methods 37(2), 173\u2013182 (1991).","journal-title":"J. Neurosci. Methods"},{"key":"18884_CR97","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","volume":"32","author":"RJ Racine","year":"1972","unstructured":"Racine, R. J. Modification of seizure activity by electrical stimulation II. Motor seizure. Electroencephalogr. Clin. Neurophysiol. 32, 281\u2013294 (1972).","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"issue":"6","key":"18884_CR98","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/sj.bjp.0705692","volume":"141","author":"LV Lopes","year":"2004","unstructured":"Lopes, L. V. et al. Binding of the prototypical adenosine A2A receptor agonist CGS 21680 to the cerebral cortex of adenosine A1 and A2A receptor knockout mice. Br. J. Pharmacol. 141(6), 1006\u20131014 (2004).","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"18884_CR99","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00210-007-0135-0","volume":"375","author":"M Yang","year":"2007","unstructured":"Yang, M. et al. Characterization of the potency, selectivity, and pharmacokinetic profile for six adenosine A2A receptor antagonists. Naunyn. Schmiedebergs Arch. Pharmacol. 375(2), 133\u2013144 (2007).","journal-title":"Naunyn. Schmiedebergs Arch. Pharmacol."},{"issue":"2","key":"18884_CR100","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1101\/lm.1172609","volume":"16","author":"S Jessberger","year":"2009","unstructured":"Jessberger, S. et al. Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. Learn. Mem. 16(2), 147\u2013154 (2009).","journal-title":"Learn. Mem."},{"issue":"3","key":"18884_CR101","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/s41419-018-0351-1","volume":"9","author":"AP Sim\u00f5es","year":"2018","unstructured":"Sim\u00f5es, A. P. et al. Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation. Cell Death Dis. 9(3), 297. https:\/\/doi.org\/10.1038\/s41419-018-0351-1 (2018).","journal-title":"Cell Death Dis."},{"issue":"25","key":"18884_CR102","doi-asserted-by":"crossref","first-page":"8259","DOI":"10.1523\/JNEUROSCI.4179-08.2009","volume":"29","author":"PS Buckmaster","year":"2009","unstructured":"Buckmaster, P. S., Ingram, E. A. & Wen, X. Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy. J. Neurosci. 29(25), 8259\u20138269 (2009).","journal-title":"J. Neurosci."},{"issue":"6","key":"18884_CR103","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1523\/JNEUROSCI.4852-10.2011","volume":"31","author":"PS Buckmaster","year":"2011","unstructured":"Buckmaster, P. S. & Lew, F. H. Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy. J. Neurosci. 31(6), 2337\u20132347 (2011).","journal-title":"J. Neurosci."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-18884-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-18884-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-18884-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T11:32:17Z","timestamp":1662118337000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-18884-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,29]]},"references-count":103,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["18884"],"URL":"https:\/\/doi.org\/10.1038\/s41598-022-18884-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,29]]},"assertion":[{"value":"30 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14690"}}