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Halophytes are exposed to constant abiotic stresses, which are believed to promote the accumulation of antioxidant metabolites like polyphenols. The aim of this study was to evaluate the antioxidant and antigenotoxic properties of the ethanol extract of the aerial part of the halophyte <jats:italic>Polygonum maritimum<\/jats:italic> L. (PME), which can represent a dietary source of bioactive compounds with potential to attenuate oxidative stress-related damage. The PME exhibited a high antioxidant potential, revealed by the in vitro capacity to scavenge the free radical DPPH (IC<jats:sub>50<\/jats:sub>\u2009=\u20092.29\u2009\u00b1\u20090.10\u00a0\u03bcg\/mL) and the improved viability of the yeast <jats:italic>Saccharomyces cerevisiae<\/jats:italic> under oxidative stress (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, 10\u00a0min). An antigenotoxic effect of PME against H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>-induced oxidative stress was found in <jats:italic>S. cerevisiae<\/jats:italic> (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) with the dominant deletion assay. In vitro colorimetric assays and LC-DAD-ESI\/MS<jats:sup>n<\/jats:sup> analysis showed that PME is a polyphenol-rich extract composed of catechin, (epi)catechin dimer and trimers, quercetin and myricetin glycosides. Hence, <jats:italic>P. maritimum<\/jats:italic> is a source of antioxidant and antigenotoxic metabolites for application in industries that develop products to provide health benefits.<\/jats:p>","DOI":"10.1038\/s41598-022-20402-5","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T11:22:08Z","timestamp":1678101728000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Antigenotoxic properties of the halophyte Polygonum maritimum L. highlight its potential to mitigate oxidative stress-related damage"],"prefix":"10.1038","volume":"13","author":[{"given":"Daniela","family":"Oliveira","sequence":"first","affiliation":[]},{"given":"Maria In\u00eas","family":"Dias","sequence":"additional","affiliation":[]},{"given":"Lillian","family":"Barros","sequence":"additional","affiliation":[]},{"given":"Lu\u00edsa","family":"Cust\u00f3dio","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3989-8925","authenticated-orcid":false,"given":"Rui","family":"Oliveira","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,3,6]]},"reference":[{"key":"20402_CR1","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1080\/10408398.2020.1828263","volume":"62","author":"MM Elmassry","year":"2022","unstructured":"Elmassry, M. 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