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This work aimed to evaluate how<jats:italic>D. suzukii<\/jats:italic>metabolic and transcriptional pathways are influenced by feeding on different host fruits, and how sex influences these responses. Adult flies were allowed to feed on five different fruit-based media. Lipids, glucose, glycogen, and energy pathways-associated gene expression, were quantified. Females showed an energetic metabolism easily adaptable to the food\u2019s nutritional characteristics; in contrast, males\u2019 energetic metabolism was particularly influenced by food, predominantly those fed on raspberry media who showed changes in glucose levels and in the expression of genes associated with metabolic pathways, suggesting activation of gluconeogenesis and trehaloneogenesis as a result of nutritional deficiency. Here we present novel insight into how<jats:italic>D. suzukii<\/jats:italic>\u2019s energetic pathways are modulated depending on fruits\u2019 nutritional geometry and sex. While the females showed high adaptability in their energetic metabolism to the diet, males were more feeding-sensitive. These findings might be used not only to control this pest population but to better advise producers to invest in less suitable fruits based on the hosts\u2019 nutritional geometry.<\/jats:p>","DOI":"10.1038\/s41598-022-25509-3","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T18:02:46Z","timestamp":1670436166000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Drosophila suzukii energetic pathways are differently modulated by nutritional geometry in males and females"],"prefix":"10.1038","volume":"12","author":[{"given":"Sara","family":"Sario","sequence":"first","affiliation":[]},{"given":"Rafael J.","family":"Mendes","sequence":"additional","affiliation":[]},{"given":"F\u00e1tima","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"Laura","family":"Torres","sequence":"additional","affiliation":[]},{"given":"Concei\u00e7\u00e3o","family":"Santos","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"25509_CR1","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1073\/pnas.0710787105","volume":"105","author":"KP Lee","year":"2008","unstructured":"Lee, K. 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