{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T10:31:46Z","timestamp":1771842706384,"version":"3.50.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T00:00:00Z","timestamp":1679097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T00:00:00Z","timestamp":1679097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Coronavirus disease 2019 (COVID-19) is a pandemic infection caused by the newly discovered severe acute respiratory syndrome coronavirus 2. Remdesivir (RDV) and corticosteroids are used mainly in COVID-19 patients with acute respiratory failure. The main objective of the study was to assess the effectiveness of remdesivir with and without corticosteroids in the treatment of COVID-19 patients. We conducted a prospective observational study, including adult patients consecutively hospitalized with confirmed COVID-19 and acute respiratory failure. Patients were divided according to treatment strategy: RDV alone versus RDV with corticosteroids. The primary outcome was the time to recovery in both treatment groups. We included 374 COVID-19 adult patients, 184 were treated with RDV, and 190 were treated with RDV and corticosteroid. Patients in the RDV group had a shorter time to recovery in comparison with patients in the RDV plus corticosteroids group at 28\u00a0days after admission [11 vs. 16\u00a0days (95% confidence Interval 9.7\u201312.8; 14.9\u201317.1; <jats:italic>p<\/jats:italic>\u2009=\u2009.016)]. Patients treated with RDV alone had a shorter length of hospital stay. The use of corticosteroids as adjunctive therapy of RDV was not associated with improvement in mortality of COVID-19 patients.\n<\/jats:p>","DOI":"10.1038\/s41598-023-31544-5","type":"journal-article","created":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T20:03:17Z","timestamp":1679860997000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Remdesivir and corticosteroids in the treatment of hospitalized COVID-19 patients"],"prefix":"10.1038","volume":"13","author":[{"given":"Lu\u00eds","family":"Coelho","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2860-061X","authenticated-orcid":false,"given":"Fatima","family":"Falc\u00e3o","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"P\u00f3voa","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3302-2225","authenticated-orcid":false,"given":"Erica","family":"Viegas","sequence":"additional","affiliation":[]},{"given":"Antonio Pais","family":"Martins","sequence":"additional","affiliation":[]},{"given":"Eduarda","family":"Carmo","sequence":"additional","affiliation":[]},{"given":"Candida","family":"Fonseca","sequence":"additional","affiliation":[]},{"given":"Luis","family":"Campos","sequence":"additional","affiliation":[]},{"given":"Kamal","family":"Mansinho","sequence":"additional","affiliation":[]},{"given":"In\u00eas","family":"Carmo","sequence":"additional","affiliation":[]},{"given":"Joana","family":"Soares","sequence":"additional","affiliation":[]},{"given":"Mariana","family":"Solano","sequence":"additional","affiliation":[]},{"given":"Dina","family":"Mendes","sequence":"additional","affiliation":[]},{"given":"Ana Cl\u00e1udia","family":"Miranda","sequence":"additional","affiliation":[]},{"given":"Antonio","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Mirco","sequence":"additional","affiliation":[]},{"given":"Helena","family":"Farinha","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Aldir","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Correia","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,3,18]]},"reference":[{"issue":"8","key":"31544_CR1","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1056\/NEJMoa2001017","volume":"382","author":"N Zhu","year":"2020","unstructured":"Zhu, N. et al. 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