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Plasma treatments have been scarcely assessed on gutta-percha surfaces as a method of enhancing adhesiveness. This study aimed to evaluate the effect of low-pressure Argon and Oxygen plasma atmospheres on conventional and bioceramic gutta-percha standardized smooth discs, assessing their roughness, surface free energy, chemical structure, and sealer wettability. A Low-Pressure Plasma Cleaner by Diener Electronic (Zepto Model) was used. Different gases (Argon or Oxygen), powers (25 W, or 50 W), and exposure times (30\u00a0s, 60\u00a0s, 120\u00a0s, or 180\u00a0s) were tested in control and experimental groups. Kruskal\u2013Wallis and Student's t-test were used in data analysis. Statistically significant differences were detected when <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05. Both gases showed different behaviors according to the parameters selected. Even though chemical changes were detected, the basic molecular structure was maintained. Argon or Oxygen plasma treatments favoured the wetting of conventional and bioceramic gutta-perchas by Endoresin and AH Plus Bioceramic sealers (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Overall, the functionalization of gutta-percha surfaces with Argon or Oxygen plasma treatments can increase roughness, surface free energy and wettability, which might improve its adhesive properties when compared to non-treated gutta-percha.<\/jats:p>","DOI":"10.1038\/s41598-023-37372-x","type":"journal-article","created":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T10:02:04Z","timestamp":1690624924000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Functionalization of gutta-percha surfaces with argon and oxygen plasma treatments to enhance adhesiveness"],"prefix":"10.1038","volume":"13","author":[{"given":"In\u00eas","family":"Ferreira","sequence":"first","affiliation":[]},{"given":"Cl\u00e1udia","family":"Lopes","sequence":"additional","affiliation":[]},{"given":"Marco S.","family":"Rodrigues","sequence":"additional","affiliation":[]},{"given":"Pedro V.","family":"Rodrigues","sequence":"additional","affiliation":[]},{"given":"Cid\u00e1lia","family":"Castro","sequence":"additional","affiliation":[]},{"given":"Ana Cristina","family":"Braga","sequence":"additional","affiliation":[]},{"given":"Maria","family":"Lopes","sequence":"additional","affiliation":[]},{"given":"Filipe","family":"Vaz","sequence":"additional","affiliation":[]},{"given":"Irene","family":"Pina-Vaz","sequence":"additional","affiliation":[]},{"given":"Benjamin","family":"Mart\u00edn-Biedma","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,7,29]]},"reference":[{"key":"37372_CR1","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.dental.2013.05.002","volume":"29","author":"M Chen","year":"2013","unstructured":"Chen, M. et al. 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