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High-intensity interval training (HIIT) is effective in this regard in the general population, but there is a lack of evidence of its effectiveness during pregnancy. This study aimed to compare an 8-week HIIT program to self-performed moderate-to-vigorous physical activity among pregnant women by evaluating changes in BP after a maximal progressive cardiorespiratory exercise test (CPET) performed at pre-intervention and post-intervention time points. A total of 54 Caucasian women in uncomplicated, singleton pregnancies (age 32\u2009\u00b1\u20094 years, 22\u2009\u00b1\u20094 weeks of gestation; M\u2009\u00b1\u2009SD) with normal BP values completed the interventions. The experimental (HIIT) group (<jats:italic>n<\/jats:italic>\u2009=\u200934) completed an online supervised HIIT program consisting of three sessions per week and supplemented by an educational class once per week. Participants in the education (EDU) group (<jats:italic>n<\/jats:italic>\u2009=\u200920) attended an educational class once per week and were encouraged to perform moderate-to-vigorous physical activity (PA) on their own. Pre- and post-intervention, all women underwent a CPET on a cycle ergometer with a respiratory gas analyzer. On the day of the CPET, maternal systolic and diastolic BP (mmHg) was measured at rest (before the CPET) and approximately 60\u00a0min after the CPET using an electronic BP monitor. Identical CPET and BP measurement protocols were employed for both the HIIT and EDU groups at the pre- and post-intervention time points.  Pre-intervention, the HIIT and EDU groups both showed a decrease in systolic and diastolic BP after the CPET, though only the change in systolic BP was statistically significant (HIIT group: <jats:italic>p<\/jats:italic>\u2009=\u20090.01; EDU group: <jats:italic>p<\/jats:italic>\u2009=\u20090.001). Post-intervention, there were no significant differences in either group between resting and post-CPET BP. There were significant post-intervention differences in VO<jats:sub>2peak<\/jats:sub> (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and HR<jats:sub>max<\/jats:sub> (<jats:italic>p<\/jats:italic>\u2009=\u20090.002) between the HIIT and EDU groups. From pre- to post-intervention, the EDU and HIIT groups both showed decreases in resting systolic or diastolic BP; there was a significant difference in systolic BP in the EDU group (<jats:italic>p<\/jats:italic>\u2009=\u20090.005) and a significant difference in diastolic BP in the HIIT group (<jats:italic>p<\/jats:italic>\u2009=\u20090.03). Both groups maintained normal BP values throughout the experiment. However, HIIT, in addition to maintaining normotension, improved cardiorespiratory fitness in pregnant women. It seems that both supervised HIIT and self-performed moderate-to-vigorous PA can be recommended as strategies to prevent BP disorders during pregnancy. More studies are needed to confirm our findings.<\/jats:p><jats:p><jats:italic>Trial registration<\/jats:italic> The full study protocol was registered in ClinicalTrials.gov (NCT05009433).<\/jats:p>","DOI":"10.1038\/s41598-024-79552-3","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T13:46:22Z","timestamp":1731591982000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["High-intensity interval training is an effective exercise mode to maintain normal blood pressure during pregnancy: a randomized control trial"],"prefix":"10.1038","volume":"14","clinical-trial-number":[{"clinical-trial-number":"nct05009433","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Junjiang","family":"Sun","sequence":"first","affiliation":[]},{"given":"\u0141ukasz","family":"Radzimi\u0144ski","sequence":"additional","affiliation":[]},{"given":"Rita","family":"Santos-Rocha","sequence":"additional","affiliation":[]},{"given":"Anna","family":"Szumilewicz","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"79552_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1139\/h05-003","volume":"31","author":"TL Weissgerber","year":"2006","unstructured":"Weissgerber, T. 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