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History"}},{"value":"23 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"J.G.P. is the inventor of patents covering the diagnosis, prognosis and treatment of cancers, including those licensed to Turnstone Biologics and Therafast Bio. GK has been holding research contracts with Daiichi Sankyo, Kaleido, Lytix Pharma, PharmaMar, Osasuna Therapeutics, Samsara Therapeutics, Sanofi, Sutro, Tollys, and Vascage. GK is on the Board of Directors of the Bristol Myers Squibb Foundation France. GK is a scientific co-founder of everImmune, Osasuna Therapeutics, Sanvitalia, Samsara Therapeutics and Therafast Bio. GK is on the scientific advisory boards of Centenara Labs (formerly Rejuveron Life Sciences), Hevolution and Institut Servier. GK is the inventor of patents covering the therapeutic targeting of ACBP\/DBI, aging, cancer, cystic fibrosis, and metabolic disorders. GK\u2019s wife, Laurence Zitvogel, has held research contracts with Glaxo Smyth Kline, Incyte, Lytix, Kaleido, Innovate Pharma, Daiichi Sankyo, Pilege, Merus, Transgene, 9 m, Tusk and Roche, was on the on the Board of Directors of Transgene, is a co-founder of everImmune, and holds patents covering the treatment of cancer and therapeutic manipulation of the microbiota. GK\u2019s brother, Romano Kroemer, was an employee of Sanofi and now consults for Boehringer-Ingelheim. The funders had no role in the design of the study, writing of the manuscript, or decision to publish the results.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experiments were performed in compliance with EU Directive 2010\/63\/EU and approved by the Institutional Animal Care and Use Committee of the Cordeliers Research Center (CEEA\u2014005 \u201cCharles Darwin\u201d, registered at the French Ministry of Research; Institutional protocol number: #56742\u20132025090411497694 v3).","order":2,"name":"Ethics","label":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Perplexity AI (Claude Sonnet 5.5 model) was used for language editing, improving the clarity and grammatical accuracy of the English text, and revising the R script for ROC analyses (R_Script_ROC_curve_v15.R). The ImageJ macros (MacroLiverMRI_channel1.ijm, MacroLiverMRI_channel2.ijm) were written by C. Klein and generative AI (Gemini 3.6 Flash model) was used only to add comments and produce a readable version of the original code. The authors reviewed, tested and validated the code and take full responsibility for the content of the published article.","order":3,"name":"Ethics","label":"Declaration of generative AI and AI-assisted technologies in the manuscript preparation process","group":{"name":"EthicsHeading","label":"Declarations"}}]}}