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A major gap in knowledge is the functional impact of neuroinflammation. The posterior cingulate cortex (PCC), as the most prominent site of amyloid pathology in AD, is a pivotal region to investigate the concomitant presence of pathophysiological mechanisms such as microglia activation, indexing neuroinflammation, and changes in task related activity. Here we used a dual PET approach to simultaneously study A\u03b2 load and neuroinflammation (TSPO uptake marker), using <jats:sup>11<\/jats:sup>C-PiB and <jats:sup>11<\/jats:sup>C-PK11195 radiotracers, respectively and fMRI to study task related neural activation in an AD sample (<jats:italic>n<\/jats:italic>\u2009=\u200919) and matched controls (<jats:italic>n<\/jats:italic>\u2009=\u200919). Here we show significantly increased A\u03b2 deposition, neuroinflammation and brain activity related to a visual object working memory task in this key region. Microglia activation was associated with increased brain activity specifically in patients, independently of amyloid binding, raising the possibility that abnormal brain activity might be restored in clinical trials aimed at reducing microglia activation.<\/jats:p>","DOI":"10.1038\/s42003-022-03761-7","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T18:03:34Z","timestamp":1660154614000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Dual PET-fMRI reveals a link between neuroinflammation, amyloid binding and compensatory task-related brain activity in Alzheimer\u2019s disease"],"prefix":"10.1038","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9774-8741","authenticated-orcid":false,"given":"N\u00e1dia","family":"Can\u00e1rio","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7683-2987","authenticated-orcid":false,"given":"L\u00edlia","family":"Jorge","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7184-185X","authenticated-orcid":false,"given":"Ricardo","family":"Martins","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Santana","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4364-6373","authenticated-orcid":false,"given":"Miguel","family":"Castelo-Branco","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"3761_CR1","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3109\/00207454.2013.833510","volume":"124","author":"Z Cai","year":"2014","unstructured":"Cai, Z., Hussain, M. 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