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Interactions may range from mutualistic to parasitic depending on host species and ecological context. Their genomic repertoire suggests metabolic versatility and capacity for rapid adaptation and transitioning between free-living and host-associated lifestyles. Some lineages, however, undergo genome reduction, are host-specific, and lack cultivability. Here we present an advanced genomic perspective and updated view on the functional diversity of <jats:italic>Endozoicomonadaceae<\/jats:italic> along the mutualism-parasitism continuum. We discuss their roles in marine symbioses, potential for microbiome engineering, and highlight knowledge gaps of their ecology to be addressed in future research.<\/jats:p>","DOI":"10.1038\/s42003-025-08828-9","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T11:13:04Z","timestamp":1759403584000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A genomic view of the bacterial family Endozoicomonadaceae in marine symbioses"],"prefix":"10.1038","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1897-2551","authenticated-orcid":false,"given":"Daniela M. 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Microbiome 10, 151 (2022). Two new species of a novel Endozoicomonadaceae genus, Candidatus Gorgonimonas, were identified as dominant, chitin-degrading symbionts of temperate octocorals through reconstruction of metagenome-assembled genomes (MAGs).","journal-title":"Microbiome"},{"key":"8828_CR5","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.syapm.2006.07.003","volume":"30","author":"M Kurahashi","year":"2007","unstructured":"Kurahashi, M. & Yokota, A. Endozoicomonas elysicola gen. nov., sp. nov., a \u03b3-proteobacterium isolated from the sea slug Elysia ornata. Syst. Appl. Microbiol. 30, 202\u2013206 (2007).","journal-title":"Syst. Appl. Microbiol."},{"key":"8828_CR6","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1099\/ijs.0.042077-0","volume":"63","author":"M Nishijima","year":"2013","unstructured":"Nishijima, M., Adachi, K., Katsuta, A., Shizuri, Y. & Yamasato, K. 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