{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T11:32:15Z","timestamp":1772883135138,"version":"3.50.1"},"reference-count":80,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Cancer"],"DOI":"10.1038\/s43018-023-00641-9","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T16:02:13Z","timestamp":1696262533000},"page":"1575-1591","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Somatic evolution of marine transmissible leukemias in the common cockle, Cerastoderma edule"],"prefix":"10.1038","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4362-545X","authenticated-orcid":false,"given":"Alicia L.","family":"Bruzos","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5914-0540","authenticated-orcid":false,"given":"Mart\u00edn","family":"Santamarina","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0997-8799","authenticated-orcid":false,"given":"Daniel","family":"Garc\u00eda-Souto","sequence":"additional","affiliation":[]},{"given":"Seila","family":"D\u00edaz","sequence":"additional","affiliation":[]},{"given":"Sara","family":"Rocha","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Zamora","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1691-0474","authenticated-orcid":false,"given":"Yunah","family":"Lee","sequence":"additional","affiliation":[]},{"given":"Alejandro","family":"Vi\u00f1a-Fe\u00e1s","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3861-0483","authenticated-orcid":false,"given":"Michael A.","family":"Quail","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7924-693X","authenticated-orcid":false,"given":"Iago","family":"Otero","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Peque\u00f1o-Valtierra","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3370-4728","authenticated-orcid":false,"given":"Javier","family":"Temes","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2912-9601","authenticated-orcid":false,"given":"Jorge","family":"Rodriguez-Castro","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6399-6020","authenticated-orcid":false,"given":"Leyre","family":"Aramburu","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2032-6975","authenticated-orcid":false,"given":"Andr\u00e9","family":"Vidal-Cap\u00f3n","sequence":"additional","affiliation":[]},{"given":"Antonio","family":"Villanueva","sequence":"additional","affiliation":[]},{"given":"Dami\u00e1n","family":"Costas","sequence":"additional","affiliation":[]},{"given":"Rosana","family":"Rodr\u00edguez","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1181-9156","authenticated-orcid":false,"given":"Tamara","family":"Prieto","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9848-002X","authenticated-orcid":false,"given":"Laura","family":"Tom\u00e1s","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9532-9508","authenticated-orcid":false,"given":"Pilar","family":"Alvari\u00f1o","sequence":"additional","affiliation":[]},{"given":"Juana","family":"Alonso","sequence":"additional","affiliation":[]},{"given":"Asunci\u00f3n","family":"Cao","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2127-7757","authenticated-orcid":false,"given":"David","family":"Iglesias","sequence":"additional","affiliation":[]},{"given":"Mar\u00eda J.","family":"Carballal","sequence":"additional","affiliation":[]},{"given":"Ana M.","family":"Amaral","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9365-6775","authenticated-orcid":false,"given":"Pablo","family":"Balseiro","sequence":"additional","affiliation":[]},{"given":"Ricardo","family":"Calado","sequence":"additional","affiliation":[]},{"given":"Bouchra","family":"El Khalfi","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3477-4974","authenticated-orcid":false,"given":"Urtzi","family":"Izagirre","sequence":"additional","affiliation":[]},{"given":"Xavier","family":"de Montaudouin","sequence":"additional","affiliation":[]},{"given":"Nicolas G.","family":"Pade","sequence":"additional","affiliation":[]},{"given":"Ian","family":"Probert","sequence":"additional","affiliation":[]},{"given":"Fernando","family":"Ricardo","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7285-0202","authenticated-orcid":false,"given":"Pamela","family":"Ruiz","sequence":"additional","affiliation":[]},{"given":"Maria","family":"Skazina","sequence":"additional","affiliation":[]},{"given":"Katarzyna","family":"Smolarz","sequence":"additional","affiliation":[]},{"given":"Juan J.","family":"Pasantes","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8049-0502","authenticated-orcid":false,"given":"Antonio","family":"Villalba","sequence":"additional","affiliation":[]},{"given":"Zemin","family":"Ning","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5514-4189","authenticated-orcid":false,"given":"Young Seok","family":"Ju","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1407-3406","authenticated-orcid":false,"given":"David","family":"Posada","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2660-2478","authenticated-orcid":false,"given":"Jonas","family":"Demeulemeester","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9201-4420","authenticated-orcid":false,"given":"Adrian","family":"Baez-Ortega","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3540-2459","authenticated-orcid":false,"given":"Jose M. C.","family":"Tubio","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,10,2]]},"reference":[{"key":"641_CR1","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1038\/onc.2009.350","volume":"27","author":"EP Murchison","year":"2009","unstructured":"Murchison, E. P. Clonally transmissible cancers in dogs and Tasmanian devils. Oncogene 27, S19\u2013S30 (2009).","journal-title":"Oncogene"},{"key":"641_CR2","doi-asserted-by":"crossref","first-page":"e1005904","DOI":"10.1371\/journal.ppat.1005904","volume":"12","author":"MJ Metzger","year":"2016","unstructured":"Metzger, M. J. & Goff, S. P. A sixth modality of infectious disease: contagious cancer from devils to clams and beyond. PLoS Pathog. 12, e1005904 (2016).","journal-title":"PLoS Pathog."},{"key":"641_CR3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0065-230X(08)60943-4","volume":"43","author":"D Cohen","year":"1985","unstructured":"Cohen, D. The canine transmissible venereal tumor: a unique result of tumor progression. Adv. Cancer Res. 43, 75\u2013112 (1985).","journal-title":"Adv. Cancer Res."},{"key":"641_CR4","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.cell.2006.05.051","volume":"126","author":"C Murgia","year":"2006","unstructured":"Murgia, C., Pritchard, J. K., Kim, S. Y., Fassati, A. & Weiss, R. A. Clonal origin and evolution of a transmissible cancer. Cell 126, 477\u2013487 (2006).","journal-title":"Cell"},{"key":"641_CR5","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1126\/science.1247167","volume":"343","author":"EP Murchison","year":"2014","unstructured":"Murchison, E. P. et al. Transmissible dog cancer genome reveals the origin and history of an ancient cell lineage. Science 343, 437\u2013440 (2014).","journal-title":"Science"},{"key":"641_CR6","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/439549a","volume":"439","author":"A-M Pearse","year":"2006","unstructured":"Pearse, A.-M. & Swift, K. Transmission of devil facial-tumour disease. Nature 439, 549\u2013549 (2006).","journal-title":"Nature"},{"key":"641_CR7","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cell.2011.11.065","volume":"148","author":"EP Murchison","year":"2012","unstructured":"Murchison, E. P. et al. Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer. Cell 148, 780\u2013791 (2012).","journal-title":"Cell"},{"key":"641_CR8","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1126\/science.abq6453","volume":"380","author":"MR Stammnitz","year":"2023","unstructured":"Stammnitz, M. R. et al. The evolution of two transmissible cancers in Tasmanian devils. Science 380, 283\u2013293 (2023).","journal-title":"Science"},{"key":"641_CR9","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.cell.2015.02.042","volume":"161","author":"MJ Metzger","year":"2015","unstructured":"Metzger, M. J., Reinisch, C., Sherry, J. & Goff, S. P. Horizontal transmission of clonal cancer cells causes leukemia in soft-shell clams. Cell 161, 255\u2013263 (2015).","journal-title":"Cell"},{"key":"641_CR10","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/nature18599","volume":"534","author":"MJ Metzger","year":"2016","unstructured":"Metzger, M. J. et al. Widespread transmission of independent cancer lineages within multiple bivalve species. Nature 534, 705\u2013709 (2016).","journal-title":"Nature"},{"key":"641_CR11","doi-asserted-by":"crossref","first-page":"e47788","DOI":"10.7554\/eLife.47788","volume":"8","author":"MA Yonemitsu","year":"2019","unstructured":"Yonemitsu, M. A. et al. A single clonal lineage of transmissible cancer identified in two marine mussel species in South America and Europe. eLife 8, e47788 (2019).","journal-title":"eLife"},{"key":"641_CR12","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-85098-5","volume":"11","author":"M Skazina","year":"2021","unstructured":"Skazina, M. et al. First description of a widespread Mytilus trossulus-derived bivalve transmissible cancer lineage in M. trossulus itself. Sci. Rep. 11, 5809 (2021).","journal-title":"Sci. Rep."},{"key":"641_CR13","doi-asserted-by":"crossref","first-page":"e66946","DOI":"10.7554\/eLife.66946","volume":"11","author":"D Garcia-Souto","year":"2022","unstructured":"Garcia-Souto, D. et al. Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe. eLife 11, e66946 (2022).","journal-title":"eLife"},{"key":"641_CR14","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.1111\/mec.16464","volume":"31","author":"A Michnowska","year":"2022","unstructured":"Michnowska, A., Hart, S. F. M., Smolarz, K., Hallmann, A. & Metzger, M. J. Horizontal transmission of disseminated neoplasia in the widespread clam Macoma balthica from the Southern Baltic Sea. Mol. Ecol. 31, 3128\u20133136 (2022).","journal-title":"Mol. Ecol."},{"key":"641_CR15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jip.2015.06.004","volume":"131","author":"MJ Carballal","year":"2015","unstructured":"Carballal, M. J., Barber, B. J., Iglesias, D. & Villalba, A. Neoplastic diseases of marine bivalves. J. Invertebr. Pathol. 131, 83\u2013106 (2015).","journal-title":"J. Invertebr. Pathol."},{"key":"641_CR16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3354\/dao004135","volume":"4","author":"RA Elston","year":"1988","unstructured":"Elston, R. A., Kent, M. & Drum, A. Progression, lethality and remission of hemic neoplasia in the bay mussel Mytilus edulis. Dis. Aquat. Organ. 4, 135\u2013142 (1988).","journal-title":"Dis. Aquat. Organ."},{"key":"641_CR17","doi-asserted-by":"crossref","first-page":"107271","DOI":"10.1016\/j.jip.2019.107271","volume":"168","author":"EAV Burioli","year":"2019","unstructured":"Burioli, E. A. V. et al. Implementation of various approaches to study the prevalence, incidence and progression of disseminated neoplasia in mussel stocks. J. Invertebr. Pathol. 168, 107271 (2019).","journal-title":"J. Invertebr. Pathol."},{"key":"641_CR18","doi-asserted-by":"crossref","unstructured":"Hayward, P. J. & Ryland, J. S. Handbook of the Marine Fauna of North-West Europe (Oxford Univ. Press, 2017).","DOI":"10.1093\/acprof:oso\/9780199549443.001.0001"},{"key":"641_CR19","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0022-2011(84)90052-1","volume":"44","author":"E Twomey","year":"1984","unstructured":"Twomey, E. & Mulcahy, M. F. A proliferative disorder of possible hemic origin in the common cockle, Cerastoderma edule. J. Invertebr. Pathol. 44, 109\u2013111 (1984).","journal-title":"J. Invertebr. Pathol."},{"key":"641_CR20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3354\/dao046213","volume":"46","author":"A Villalba","year":"2001","unstructured":"Villalba, A., Carballal, M. J. & L\u00f3pez, C. Disseminated neoplasia and large foci indicating heavy haemocytic infiltration in cockles Cerastoderma edule from Galicia (NW Spain). Dis. Aquat. Organ. 46, 213\u2013216 (2001).","journal-title":"Dis. Aquat. Organ."},{"key":"641_CR21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1006\/jipa.2001.5049","volume":"78","author":"MJ Carballal","year":"2001","unstructured":"Carballal, M. J., Iglesias, D., Santamarina, J., Ferro-Soto, B. & Villalba, A. Parasites and pathologic conditions of the cockle Cerastoderma edule populations of the coast of Galicia (NW Spain). J. Invertebr. Pathol. 78, 87\u201397 (2001).","journal-title":"J. Invertebr. Pathol."},{"key":"641_CR22","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1111\/jfd.12436","volume":"39","author":"S D\u00edaz","year":"2016","unstructured":"D\u00edaz, S., Iglesias, D., Villalba, A. & Carballal, M. J. Long-term epidemiological study of disseminated neoplasia of cockles in Galicia (NW Spain): temporal patterns at individual and population levels, influence of environmental and cockle-based factors and lethality. J. Fish Dis. 39, 1027\u20131042 (2016).","journal-title":"J. Fish Dis."},{"key":"641_CR23","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/mec.16052","volume":"31","author":"M Hammel","year":"2022","unstructured":"Hammel, M. et al. Prevalence and polymorphism of a mussel transmissible cancer in Europe. Mol. Ecol. 31, 736\u2013751 (2022).","journal-title":"Mol. Ecol."},{"key":"641_CR24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF01732067","volume":"16","author":"T Miyata","year":"1980","unstructured":"Miyata, T. & Yasunaga, T. Molecular evolution of mRNA: a method for estimating evolutionary rates of synonymous and amino acid substitutions from homologous nucleotide sequences and its application. J. Mol. Evol. 16, 23\u201336 (1980).","journal-title":"J. Mol. Evol."},{"key":"641_CR25","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.cell.2017.09.042","volume":"171","author":"I Martincorena","year":"2017","unstructured":"Martincorena, I. et al. Universal patterns of selection in cancer and somatic tissues. Cell 171, 1029\u20131041.e21 (2017).","journal-title":"Cell"},{"key":"641_CR26","doi-asserted-by":"crossref","first-page":"eaau9923","DOI":"10.1126\/science.aau9923","volume":"365","author":"A Baez-Ortega","year":"2019","unstructured":"Baez-Ortega, A. et al. Somatic evolution and global expansion of an ancient transmissible cancer lineage. Science 365, eaau9923 (2019).","journal-title":"Science"},{"key":"641_CR27","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1007\/s00227-015-2676-y","volume":"162","author":"L Mart\u00ednez","year":"2015","unstructured":"Mart\u00ednez, L., Freire, R., Arias-P\u00e9rez, A., M\u00e9ndez, J. & Insua, A. Patterns of genetic variation across the distribution range of the cockle Cerastoderma edule inferred from microsatellites and mitochondrial DNA. Mar. Biol. 162, 1393\u20131406 (2015).","journal-title":"Mar. Biol."},{"key":"641_CR28","doi-asserted-by":"publisher","unstructured":"Hart, S. F. M. et al. Centuries of genome instability and evolution in soft-shell clam, Mya arenaria, bivalve transmissible neoplasia. Nat. Cancer https:\/\/doi.org\/10.1038\/s43018-023-00643-7 (2023).","DOI":"10.1038\/s43018-023-00643-7"},{"key":"641_CR29","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1126\/science.1197696","volume":"331","author":"CA Rebbeck","year":"2011","unstructured":"Rebbeck, C. A., Leroi, A. M. & Burt, A. Mitochondrial capture by a transmissible cancer. Science 331, 303\u2013303 (2011).","journal-title":"Science"},{"key":"641_CR30","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-16765-w","volume":"11","author":"A Strakova","year":"2020","unstructured":"Strakova, A. et al. Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer. Nat. Commun. 11, 3059 (2020).","journal-title":"Nat. Commun."},{"key":"641_CR31","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1073\/pnas.0510511103","volume":"103","author":"JL Spees","year":"2006","unstructured":"Spees, J. L., Olson, S. D., Whitney, M. J. & Prockop, D. J. Mitochondrial transfer between cells can rescue aerobic respiration. Proc. Natl Acad. Sci. USA 103, 1283\u20131288 (2006).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"641_CR32","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cmet.2014.12.003","volume":"21","author":"AS Tan","year":"2015","unstructured":"Tan, A. S. et al. Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA. Cell Metab. 21, 81\u201394 (2015).","journal-title":"Cell Metab."},{"key":"641_CR33","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41565-021-01000-4","volume":"17","author":"T Saha","year":"2022","unstructured":"Saha, T. et al. Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells. Nat. Nanotechnol. 17, 98\u2013106 (2022).","journal-title":"Nat. Nanotechnol."},{"key":"641_CR34","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3354\/meps11672","volume":"549","author":"ME Cross","year":"2016","unstructured":"Cross, M. E. et al. Genetic evidence supports recolonisation by Mya arenaria of western Europe from North America. Mar. Ecol. Prog. Ser. 549, 99\u2013112 (2016).","journal-title":"Mar. Ecol. Prog. Ser."},{"key":"641_CR35","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41586-020-1943-3","volume":"578","author":"LB Alexandrov","year":"2020","unstructured":"Alexandrov, L. B. et al. The repertoire of mutational signatures in human cancer. Nature 578, 94\u2013101 (2020).","journal-title":"Nature"},{"key":"641_CR36","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/s41588-019-0557-x","volume":"52","author":"Y Yuan","year":"2020","unstructured":"Yuan, Y. et al. Comprehensive molecular characterization of mitochondrial genomes in human cancers. Nat. Genet. 52, 342\u2013352 (2020).","journal-title":"Nat. Genet."},{"key":"641_CR37","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature12477","volume":"500","author":"LB Alexandrov","year":"2013","unstructured":"Alexandrov, L. B. et al. Signatures of mutational processes in human cancer. Nature 500, 415\u2013421 (2013).","journal-title":"Nature"},{"key":"641_CR38","doi-asserted-by":"publisher","unstructured":"Gori, K. & Baez-Ortega, A. sigfit: flexible Bayesian inference of mutational signatures. Preprint at bioRxiv https:\/\/doi.org\/10.1101\/372896 (2020).","DOI":"10.1101\/372896"},{"key":"641_CR39","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1021\/bi00713a035","volume":"13","author":"T Lindahl","year":"1974","unstructured":"Lindahl, T. & Nyberg, B. Heat-induced deamination of cytosine residues in deoxyribonucleic acid. Biochemistry 13, 3405\u20133410 (1974).","journal-title":"Biochemistry"},{"key":"641_CR40","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/s43018-021-00200-0","volume":"2","author":"X Zou","year":"2021","unstructured":"Zou, X. et al. A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage. Nat. Cancer 2, 643\u2013657 (2021).","journal-title":"Nat. Cancer"},{"key":"641_CR41","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature17676","volume":"534","author":"S Nik-Zainal","year":"2016","unstructured":"Nik-Zainal, S. et al. Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature 534, 47\u201354 (2016).","journal-title":"Nature"},{"key":"641_CR42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-019-0734-6","volume":"3","author":"VK Singh","year":"2020","unstructured":"Singh, V. K., Rastogi, A., Hu, X., Wang, Y. & De, S. Mutational signature SBS8 predominantly arises due to late replication errors in cancer. Commun. Biol. 3, 1\u201310 (2020).","journal-title":"Commun. Biol."},{"key":"641_CR43","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jip.2010.01.011","volume":"104","author":"F Le Grand","year":"2010","unstructured":"Le Grand, F. et al. Prevalence, intensity, and aneuploidy patterns of disseminated neoplasia in cockles (Cerastoderma edule) from Arcachon Bay: seasonal variation and position in sediment. J. Invertebr. Pathol. 104, 110\u2013118 (2010).","journal-title":"J. Invertebr. Pathol."},{"key":"641_CR44","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jip.2013.03.010","volume":"113","author":"S D\u00edaz","year":"2013","unstructured":"D\u00edaz, S. et al. Disseminated neoplasia causes changes in ploidy and apoptosis frequency in cockles Cerastoderma edule. J. Invertebr. Pathol. 113, 214\u2013219 (2013).","journal-title":"J. Invertebr. Pathol."},{"key":"641_CR45","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.aquaculture.2014.03.017","volume":"428\u2013429","author":"AM Matias","year":"2014","unstructured":"Matias, A. M. et al. Karyotype variation in neoplastic cells associated to severity of disseminated neoplasia in the cockle Cerastoderma edule. Aquaculture 428\u2013429, 223\u2013225 (2014).","journal-title":"Aquaculture"},{"key":"641_CR46","doi-asserted-by":"crossref","first-page":"a026336","DOI":"10.1101\/cshperspect.a026336","volume":"6","author":"JD Oliner","year":"2016","unstructured":"Oliner, J. D., Saiki, A. Y. & Caenepeel, S. The role of MDM2 amplification and overexpression in tumorigenesis. Cold Spring Harb. Perspect. Med. 6, a026336 (2016).","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"641_CR47","doi-asserted-by":"publisher","unstructured":"Kato, S. et al. Analysis of MDM2 amplification: next-generation sequencing of patients with diverse malignancies. JCO Precis. Oncol. https:\/\/doi.org\/10.1200\/PO.17.00235 (2018).","DOI":"10.1200\/PO.17.00235"},{"key":"641_CR48","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1750-3639.1999.tb00532.x","volume":"9","author":"R B\u00fcschges","year":"1999","unstructured":"B\u00fcschges, R. et al. Amplification and expression of cyclin D genes (CCND1 CCND2 and CCND3) in human malignant gliomas. Brain Pathol. 9, 435\u2013442 (1999).","journal-title":"Brain Pathol."},{"key":"641_CR49","doi-asserted-by":"crossref","first-page":"8265","DOI":"10.1158\/1078-0432.CCR-05-1028","volume":"11","author":"Y Kasugai","year":"2005","unstructured":"Kasugai, Y. et al. Identification of CCND3 and BYSL as candidate targets for the 6p21 amplification in diffuse large B-cell lymphoma. Clin. Cancer Res. 11, 8265\u20138272 (2005).","journal-title":"Clin. Cancer Res."},{"key":"641_CR50","doi-asserted-by":"crossref","unstructured":"Pegg, A. E., Dolan, M. E. & Moschel, R. C. in Progress in Nucleic Acid Research and Molecular Biology, Vol. 51 (eds Cohn, W. E. & Moldave, K.) 167\u2013223 (Academic Press, 1995).","DOI":"10.1016\/S0079-6603(08)60879-X"},{"key":"641_CR51","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1093\/carcin\/21.10.1879","volume":"21","author":"A Shiraishi","year":"2000","unstructured":"Shiraishi, A., Sakumi, K. & Sekiguchi, M. Increased susceptibility to chemotherapeutic alkylating agents of mice deficient in DNA repair methyltransferase. Carcinogenesis 21, 1879\u20131883 (2000).","journal-title":"Carcinogenesis"},{"key":"641_CR52","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.gde.2018.03.003","volume":"49","author":"SS Lower","year":"2018","unstructured":"Lower, S. S., McGurk, M. P., Clark, A. G. & Barbash, D. A. Satellite DNA evolution: old ideas, new approaches. Curr. Opin. Genet. Dev. 49, 70\u201378 (2018).","journal-title":"Curr. Opin. Genet. Dev."},{"key":"641_CR53","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1146\/annurev-cellbio-092910-154234","volume":"27","author":"T Davoli","year":"2011","unstructured":"Davoli, T. & de Lange, T. The causes and consequences of polyploidy in normal development and cancer. Annu. Rev. Cell Dev. Biol. 27, 585\u2013610 (2011).","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"641_CR54","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/s41586-022-04578-4","volume":"604","author":"S Gemble","year":"2022","unstructured":"Gemble, S. et al. Genetic instability from a single S phase after whole-genome duplication. Nature 604, 146\u2013151 (2022).","journal-title":"Nature"},{"key":"641_CR55","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nrm4025","volume":"16","author":"S Santaguida","year":"2015","unstructured":"Santaguida, S. & Amon, A. Short- and long-term effects of chromosome mis-segregation and aneuploidy. Nat. Rev. Mol. Cell Biol. 16, 473\u2013485 (2015).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"641_CR56","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/s41588-019-0360-8","volume":"51","author":"P Ly","year":"2019","unstructured":"Ly, P. et al. Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements. Nat. Genet. 51, 705\u2013715 (2019).","journal-title":"Nat. Genet."},{"key":"641_CR57","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/annonc\/mdw612","volume":"28","author":"A Crockford","year":"2017","unstructured":"Crockford, A. et al. Cyclin D mediates tolerance of genome-doubling in cancers with functional p53. Ann. Oncol. 28, 149\u2013p156 (2017).","journal-title":"Ann. Oncol."},{"key":"641_CR58","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1182\/bloodadvances.2018019398","volume":"2","author":"H Matsuo","year":"2018","unstructured":"Matsuo, H. et al. Recurrent CCND3 mutations in MLL-rearranged acute myeloid leukemia. Blood Adv. 2, 2879\u20132889 (2018).","journal-title":"Blood Adv."},{"key":"641_CR59","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.2353\/ajpath.2006.050603","volume":"168","author":"C Walker","year":"2006","unstructured":"Walker, C., B\u00f6ttger, S. & Low, B. Mortalin-based cytoplasmic sequestration of p53 in a nonmammalian cancer model. Am. J. Pathol. 168, 1526\u20131530 (2006).","journal-title":"Am. J. Pathol."},{"key":"641_CR60","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1073\/pnas.1519691113","volume":"113","author":"RJ Pye","year":"2016","unstructured":"Pye, R. J. et al. A second transmissible cancer in Tasmanian devils. Proc. Natl Acad. Sci. USA 113, 374\u2013379 (2016).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"641_CR61","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-07231-7","volume":"7","author":"D Garc\u00eda-Souto","year":"2017","unstructured":"Garc\u00eda-Souto, D. et al. Methylation profile of a satellite DNA constituting the intercalary G\u2009+\u2009C-rich heterochromatin of the cut trough shell Spisula subtruncata (Bivalvia, Mactridae). Sci. Rep. 7, 6930 (2017).","journal-title":"Sci. Rep."},{"key":"641_CR62","unstructured":"Li, H. Aligning sequence reads, clone sequences and assembly contigs with BWA-MEM. arXiv:1303.3997 [q-bio] (2013)."},{"key":"641_CR63","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","volume":"25","author":"H Li","year":"2009","unstructured":"Li, H. et al. The Sequence Alignment\/Map format and SAMtools. Bioinformatics 25, 2078\u20132079 (2009).","journal-title":"Bioinformatics"},{"key":"641_CR64","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29, 15\u201321 (2013).","journal-title":"Bioinformatics"},{"key":"641_CR65","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/1471-2105-12-S6-S3","volume":"12","author":"N Parrish","year":"2011","unstructured":"Parrish, N., Hormozdiari, F. & Eskin, E. Assembly of non-unique insertion content using next-generation sequencing. BMC Bioinformatics 12, S3 (2011).","journal-title":"BMC Bioinformatics"},{"key":"641_CR66","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s10577-005-0983-8","volume":"13","author":"NS Hurtado","year":"2005","unstructured":"Hurtado, N. S. & Pasantes, J. J. Surface spreading of synaptonemal complexes in the clam Dosinia exoleta (Mollusca, Bivalvia). Chromosome Res. 13, 575\u2013580 (2005).","journal-title":"Chromosome Res."},{"key":"641_CR67","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.gpb.2016.05.004","volume":"14","author":"H Lu","year":"2016","unstructured":"Lu, H., Giordano, F. & Ning, Z. Oxford Nanopore MinION sequencing and genome assembly. Genomics Proteomics Bioinformatics 14, 265\u2013279 (2016).","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"641_CR68","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1101\/gr.213405.116","volume":"27","author":"AV Zimin","year":"2017","unstructured":"Zimin, A. V. et al. Hybrid assembly of the large and highly repetitive genome of Aegilops tauschii, a progenitor of bread wheat, with the MaSuRCA mega-reads algorithm. Genome Res. 27, 787\u2013792 (2017).","journal-title":"Genome Res."},{"key":"641_CR69","doi-asserted-by":"publisher","unstructured":"Poplin, R. et al. Scaling accurate genetic variant discovery to tens of thousands of samples. Preprint at bioRxiv https:\/\/doi.org\/10.1101\/201178 (2017).","DOI":"10.1101\/201178"},{"key":"641_CR70","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","volume":"37","author":"D Kim","year":"2019","unstructured":"Kim, D., Paggi, J. M., Park, C., Bennett, C. & Salzberg, S. L. Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. Nat. Biotechnol. 37, 907\u2013915 (2019).","journal-title":"Nat. Biotechnol."},{"key":"641_CR71","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nbt.2514","volume":"31","author":"K Cibulskis","year":"2013","unstructured":"Cibulskis, K. et al. Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples. Nat. Biotechnol. 31, 213\u2013219 (2013).","journal-title":"Nat. Biotechnol."},{"key":"641_CR72","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/molbev\/msz189","volume":"37","author":"D Darriba","year":"2020","unstructured":"Darriba, D. et al. ModelTest-NG: a new and scalable tool for the selection of DNA and protein evolutionary models. Mol. Biol. Evol. 37, 291\u2013294 (2020).","journal-title":"Mol. Biol. Evol."},{"key":"641_CR73","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/cla.12223","volume":"34","author":"Y Jin","year":"2018","unstructured":"Jin, Y. & Brown, R. P. Partition number, rate priors and unreliable divergence times in Bayesian phylogenetic dating. Cladistics 34, 568\u2013573 (2018).","journal-title":"Cladistics"},{"key":"641_CR74","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/ng.3036","volume":"46","author":"A Rimmer","year":"2014","unstructured":"Rimmer, A. et al. Integrating mapping-, assembly- and haplotype-based approaches for calling variants in clinical sequencing applications. Nat. Genet. 46, 912\u2013918 (2014).","journal-title":"Nat. Genet."},{"key":"641_CR75","doi-asserted-by":"crossref","first-page":"i333","DOI":"10.1093\/bioinformatics\/bts378","volume":"28","author":"T Rausch","year":"2012","unstructured":"Rausch, T. et al. DELLY: structural variant discovery by integrated paired-end and split-read analysis. Bioinformatics 28, i333\u2013i339 (2012).","journal-title":"Bioinformatics"},{"key":"641_CR76","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2014-15-6-r84","volume":"15","author":"RM Layer","year":"2014","unstructured":"Layer, R. M., Chiang, C., Quinlan, A. R. & Hall, I. M. LUMPY: a probabilistic framework for structural variant discovery. Genome Biol. 15, R84 (2014).","journal-title":"Genome Biol."},{"key":"641_CR77","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1093\/bioinformatics\/btv710","volume":"32","author":"X Chen","year":"2016","unstructured":"Chen, X. et al. Manta: rapid detection of structural variants and indels for germline and cancer sequencing applications. Bioinformatics 32, 1220\u20131222 (2016).","journal-title":"Bioinformatics"},{"key":"641_CR78","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1096-0031.1999.tb00277.x","volume":"15","author":"KC Nixon","year":"1999","unstructured":"Nixon, K. C. The Parsimony Ratchet, a new method for rapid parsimony analysis. Cladistics 15, 407\u2013414 (1999).","journal-title":"Cladistics"},{"key":"641_CR79","doi-asserted-by":"crossref","DOI":"10.1186\/s13039-015-0150-7","volume":"8","author":"D Garc\u00eda-Souto","year":"2015","unstructured":"Garc\u00eda-Souto, D., P\u00e9rez-Garc\u00eda, C., Mor\u00e1n, P. & Pasantes, J. J. Divergent evolutionary behavior of H3 histone gene and rDNA clusters in venerid clams. Mol. Cytogenet. 8, 40 (2015).","journal-title":"Mol. Cytogenet."},{"key":"641_CR80","doi-asserted-by":"crossref","DOI":"10.1186\/1297-9686-31-5-509","volume":"31","author":"A Insua","year":"1999","unstructured":"Insua, A., Freire, R. & M\u00e9ndez, J. The 5S rDNA of the bivalve Cerastoderma edule: nucleotide sequence of the repeat unit and chromosomal location relative to 18S\u201328S rDNA. Genet. Sel. Evol. 31, 509 (1999).","journal-title":"Genet. Sel. Evol."}],"container-title":["Nature Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s43018-023-00641-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s43018-023-00641-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s43018-023-00641-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T08:29:22Z","timestamp":1700641762000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s43018-023-00641-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,2]]},"references-count":80,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["641"],"URL":"https:\/\/doi.org\/10.1038\/s43018-023-00641-9","relation":{},"ISSN":["2662-1347"],"issn-type":[{"value":"2662-1347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,2]]},"assertion":[{"value":"22 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}