{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:46:56Z","timestamp":1787791616879,"version":"build-2784847793"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100011186","name":"CAS | Institute of Zoology, Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011186","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Aging"],"DOI":"10.1038\/s43587-026-01190-3","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:03:20Z","timestamp":1787735000000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Contractile myografts confer systemic anti-aging benefits"],"prefix":"10.1038","author":[{"given":"Xupeng","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyue","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5391-4477","authenticated-orcid":false,"given":"Pengbin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3138-9525","authenticated-orcid":false,"given":"Ng","family":"Shyh-Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"1190_CR1","doi-asserted-by":"publisher","unstructured":"Prado, C. M., Batsis, J. A., Donini, L. M., Gonzalez, M. C. & Siervo, M. Sarcopenic obesity in older adults: a clinical overview. Nat. Rev. Endocrinol. https:\/\/doi.org\/10.1038\/s41574-023-00943-z (2024).","DOI":"10.1038\/s41574-023-00943-z"},{"key":"1190_CR2","doi-asserted-by":"publisher","first-page":"e13712","DOI":"10.1111\/cpr.13712","volume":"57","author":"Y Cheng","year":"2024","unstructured":"Cheng, Y. et al. The metabaging cycle promotes non-metabolic chronic diseases of ageing. Cell Prolif. 57, e13712 (2024).","journal-title":"Cell Prolif."},{"key":"1190_CR3","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1056\/NEJMoa1614362","volume":"377","author":"A Afshin","year":"2017","unstructured":"Afshin, A. et al. Health effects of overweight and obesity in 195 countries over 25 years. New Engl. J. Med. 377, 13\u201327 (2017).","journal-title":"New Engl. J. Med."},{"key":"1190_CR4","unstructured":"World Health Organization. WHO European Regional Obesity Report (WHO, 2022)."},{"key":"1190_CR5","doi-asserted-by":"publisher","first-page":"e13811","DOI":"10.1111\/eci.13811","volume":"52","author":"P Y\u00e1rnoz-Esquiroz","year":"2022","unstructured":"Y\u00e1rnoz-Esquiroz, P. et al. \u2018Obesities\u2019: position statement on a complex disease entity with multifaceted drivers. Eur. J. Clin. Invest. 52, e13811 (2022).","journal-title":"Eur. J. Clin. Invest."},{"key":"1190_CR6","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nrendo.2012.49","volume":"8","author":"BK Pedersen","year":"2012","unstructured":"Pedersen, B. K. & Febbraio, M. A. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat. Rev. Endocrinol. 8, 457\u2013465 (2012).","journal-title":"Nat. Rev. Endocrinol."},{"key":"1190_CR7","doi-asserted-by":"publisher","first-page":"eabg3947","DOI":"10.1126\/sciadv.abg3947","volume":"7","author":"M Beckerman","year":"2021","unstructured":"Beckerman, M. et al. GLUT4-overexpressing engineered muscle constructs as a therapeutic platform to normalize glycemia in diabetic mice. Sci. Adv. 7, eabg3947 (2021).","journal-title":"Sci. Adv."},{"key":"1190_CR8","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.coph.2017.05.005","volume":"34","author":"J Giudice","year":"2017","unstructured":"Giudice, J. & Taylor, J. M. Muscle as a paracrine and endocrine organ. Curr. Opin. Pharmacol. 34, 49\u201355 (2017).","journal-title":"Curr. Opin. Pharmacol."},{"key":"1190_CR9","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1210\/endrev\/bnaa016","volume":"41","author":"MCK Severinsen","year":"2020","unstructured":"Severinsen, M. C. K. & Pedersen, B. K. Muscle-organ crosstalk: the emerging roles of myokines. Endocrine Rev. 41, 594\u2013609 (2020).","journal-title":"Endocrine Rev."},{"key":"1190_CR10","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/nrm3265","volume":"13","author":"YX Wang","year":"2011","unstructured":"Wang, Y. X. & Rudnicki, M. A. Satellite cells, the engines of muscle repair. Nat. Rev. Mol. Cell Biol. 13, 127\u2013133 (2011).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"1190_CR11","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1002\/jez.1402060314","volume":"206","author":"E Schultz","year":"1978","unstructured":"Schultz, E., Gibson, M. C. & Champion, T. Satellite cells are mitotically quiescent in mature mouse muscle: an EM and radioautographic study. J. Exp. Zool. 206, 451\u2013456 (1978).","journal-title":"J. Exp. Zool."},{"key":"1190_CR12","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1083\/jcb.9.2.493","volume":"9","author":"A Mauro","year":"1961","unstructured":"Mauro, A. Satellite cell of skeletal muscle fibers. J. Biophys. Biochem. Cytol. 9, 493\u2013495 (1961).","journal-title":"J. Biophys. Biochem. Cytol."},{"key":"1190_CR13","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1097\/01.jnen.0000218443.45782.81","volume":"65","author":"D Skuk","year":"2006","unstructured":"Skuk, D. et al. Dystrophin expression in muscles of Duchenne muscular dystrophy patients after high-density injections of normal myogenic cells. J. Neuropathol. Exp. Neurol. 65, 371\u2013386 (2006).","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"1190_CR14","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.nmd.2006.10.003","volume":"17","author":"D Skuk","year":"2007","unstructured":"Skuk, D. et al. First test of a \u201chigh-density injection\u201d protocol for myogenic cell transplantation throughout large volumes of muscles in a Duchenne muscular dystrophy patient: eighteen months follow-up. Neuromuscul. Disord. 17, 38\u201346 (2007).","journal-title":"Neuromuscul. Disord."},{"key":"1190_CR15","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3727\/096368912X661337","volume":"23","author":"D Skuk","year":"2014","unstructured":"Skuk, D., Goulet, M. & Tremblay, J. P. Intramuscular transplantation of myogenic cells in primates: importance of needle size, cell number, and injection volume. Cell Transplant. 23, 13\u201325 (2014).","journal-title":"Cell Transplant."},{"key":"1190_CR16","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.pcad.2007.02.002","volume":"50","author":"P Menasch\u00e9","year":"2007","unstructured":"Menasch\u00e9, P. Skeletal myoblasts as a therapeutic agent. Prog. Cardiovasc. Dis. 50, 7\u201317 (2007).","journal-title":"Prog. Cardiovasc. Dis."},{"key":"1190_CR17","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1093\/ehjci\/jey064","volume":"19","author":"S Yoshida","year":"2018","unstructured":"Yoshida, S., Miyagawa, S., Toda, K., Domae, K. & Sawa, Y. Skeletal myoblast sheet transplantation enhanced regional improvement of cardiac function. Eur. Heart J. Cardiovasc. Imag. 19, 828\u2013829 (2018).","journal-title":"Eur. Heart J. Cardiovasc. Imag."},{"key":"1190_CR18","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1006\/excr.2002.5562","volume":"278","author":"P Lorenzon","year":"2002","unstructured":"Lorenzon, P. et al. Properties of primary mouse myoblasts expanded in culture. Exp. Cell. Res. 278, 84\u201391 (2002).","journal-title":"Exp. Cell. Res."},{"key":"1190_CR19","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/sj.gt.3301874","volume":"10","author":"QL Lu","year":"2003","unstructured":"Lu, Q. L., Bou-Gharios, G. & Partridge, T. A. Non-viral gene delivery in skeletal muscle: a protein factory. Gene Ther. 10, 131\u2013142 (2003).","journal-title":"Gene Ther."},{"key":"1190_CR20","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/s42003-018-0161-0","volume":"1","author":"L Perry","year":"2018","unstructured":"Perry, L., Landau, S., Flugelman, M. Y. & Levenberg, S. Genetically engineered human muscle transplant enhances murine host neovascularization and myogenesis. Commun. Biol. 1, 161 (2018).","journal-title":"Commun. Biol."},{"key":"1190_CR21","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1146\/annurev.pharmtox.40.1.295","volume":"40","author":"CR Ozawa","year":"2000","unstructured":"Ozawa, C. R., Springer, M. L. & Blau, H. M. A novel means of drug delivery: myoblast-mediated gene therapy and regulatable retroviral vectors. Annu. Rev. Pharmacol. Toxicol. 40, 295\u2013317 (2000).","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"1190_CR22","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1083\/jcb.142.5.1257","volume":"142","author":"Z Qu","year":"1998","unstructured":"Qu, Z. et al. Development of approaches to improve cell survival in myoblast transfer therapy. J. Cell Biol. 142, 1257\u20131267 (1998).","journal-title":"J. Cell Biol."},{"key":"1190_CR23","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.biomaterials.2007.09.014","volume":"29","author":"L Thorrez","year":"2008","unstructured":"Thorrez, L. et al. Growth, differentiation, transplantation and survival of human skeletal myofibers on biodegradable scaffolds. Biomaterials 29, 75\u201384 (2008).","journal-title":"Biomaterials"},{"key":"1190_CR24","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1111\/j.1582-4934.2009.00942.x","volume":"15","author":"E Jean","year":"2011","unstructured":"Jean, E. et al. Aldehyde dehydrogenase activity promotes survival of human muscle precursor cells. J. Cell. Mol. Med. 15, 119\u2013133 (2011).","journal-title":"J. Cell. Mol. Med."},{"key":"1190_CR25","first-page":"3626","volume":"123","author":"SL Rong","year":"2010","unstructured":"Rong, S. L. et al. Recombinant proteins secreted from tissue-engineered bioartificial muscle improve cardiac dysfunction and suppress cardiomyocyte apoptosis in rats with heart failure. Chinese Med. J. 123, 3626\u20132633 (2010).","journal-title":"Chinese Med. J."},{"key":"1190_CR26","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1161\/hc3101.092215","volume":"104","author":"Y Lu","year":"2001","unstructured":"Lu, Y. et al. Recombinant vascular endothelial growth factor secreted from tissue-engineered bioartificial muscles promotes localized angiogenesis. Circulation 104, 594\u2013599 (2001).","journal-title":"Circulation"},{"key":"1190_CR27","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.ymthe.2006.03.019","volume":"14","author":"L Thorrez","year":"2006","unstructured":"Thorrez, L. et al. Angiogenesis enhances factor IX delivery and persistence from retrievable human bioengineered muscle implants. Mol. Ther. 14, 442\u2013451 (2006).","journal-title":"Mol. Ther."},{"key":"1190_CR28","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.stemcr.2020.01.002","volume":"14","author":"TM Liu","year":"2020","unstructured":"Liu, T. M. et al. Ascorbate and iron are required for the specification and long-term self-renewal of human skeletal mesenchymal stromal cells. Stem Cell Reports 14, 210\u2013225 (2020).","journal-title":"Stem Cell Reports"},{"key":"1190_CR29","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/0955-3886(95)00056-9","volume":"17","author":"PL Chang","year":"1996","unstructured":"Chang, P. L. Microencapsulation\u2013an alternative approach to gene therapy. Transfus. Sci. 17, 35\u201343 (1996).","journal-title":"Transfus. Sci."},{"key":"1190_CR30","doi-asserted-by":"publisher","first-page":"2555","DOI":"10.1089\/hum.1998.9.17-2555","volume":"9","author":"H Vandenburgh","year":"1998","unstructured":"Vandenburgh, H. et al. Attenuation of skeletal muscle wasting with recombinant human growth hormone secreted from a tissue-engineered bioartificial muscle. Hum. Gene Ther. 9, 2555\u20132564 (1998).","journal-title":"Hum. Gene Ther."},{"key":"1190_CR31","doi-asserted-by":"publisher","first-page":"e13214","DOI":"10.1111\/cpr.13214","volume":"55","author":"Z Jiang","year":"2022","unstructured":"Jiang, Z. et al. Machine learning-based phenotypic screening for postmitotic growth inducers uncover vitamin D3 metabolites as small molecule ribosome agonists. Cell Prolif. 55, e13214 (2022).","journal-title":"Cell Prolif."},{"key":"1190_CR32","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/s41422-023-00818-y","volume":"33","author":"P Wang","year":"2023","unstructured":"Wang, P. et al. Lin28a maintains a subset of adult muscle stem cells in an embryonic-like state. Cell Res. 33, 712\u2013726 (2023).","journal-title":"Cell Res."},{"key":"1190_CR33","doi-asserted-by":"publisher","first-page":"14863","DOI":"10.1073\/pnas.1002220107","volume":"107","author":"G Valdez","year":"2010","unstructured":"Valdez, G. et al. Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise. PNAS 107, 14863\u201314868 (2010).","journal-title":"PNAS"},{"key":"1190_CR34","doi-asserted-by":"publisher","DOI":"10.1186\/s13395-020-00233-6","volume":"10","author":"RL Hastings","year":"2020","unstructured":"Hastings, R. L., Massopust, R. T., Haddix, S. G., Lee, Y. I. & Thompson, W. J. Exclusive vital labeling of myonuclei for studying myonuclear arrangement in mouse skeletal muscle tissue. Skelet. Muscle 10, 15 (2020).","journal-title":"Skelet. Muscle"},{"key":"1190_CR35","doi-asserted-by":"publisher","first-page":"e12943","DOI":"10.1111\/acel.12943","volume":"18","author":"H Tang","year":"2019","unstructured":"Tang, H. et al. mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism. Aging Cell 18, e12943 (2019).","journal-title":"Aging Cell"},{"key":"1190_CR36","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1016\/j.exger.2006.09.008","volume":"41","author":"R Gruber","year":"2006","unstructured":"Gruber, R. et al. Fracture healing in the elderly patient. Exp. Gerontol. 41, 1080\u20131093 (2006).","journal-title":"Exp. Gerontol."},{"key":"1190_CR37","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1002\/jbmr.2769","volume":"31","author":"R Bi","year":"2016","unstructured":"Bi, R. et al. Diphtheria toxin- and GFP-based mouse models of acquired hypoparathyroidism and treatment with a long-acting parathyroid hormone analog. J. Bone Mineral Res. 31, 975\u2013984 (2016).","journal-title":"J. Bone Mineral Res."},{"key":"1190_CR38","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41392-019-0036-y","volume":"4","author":"M Lu","year":"2019","unstructured":"Lu, M., Flanagan, J. U., Langley, R. J., Hay, M. P. & Perry, J. K. Targeting growth hormone function: strategies and therapeutic applications. Signal Transduct. Target. Ther. 4, 3 (2019).","journal-title":"Signal Transduct. Target. Ther."},{"key":"1190_CR39","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1210\/er.2008-0027","volume":"30","author":"N M\u00f8ller","year":"2009","unstructured":"M\u00f8ller, N. & J\u00f8rgensen, J. O. Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. Endocrine Rev. 30, 152\u2013177 (2009).","journal-title":"Endocrine Rev."},{"key":"1190_CR40","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/337176a0","volume":"337","author":"TA Partridge","year":"1989","unstructured":"Partridge, T. A., Morgan, J. E., Coulton, G. R., Hoffman, E. P. & Kunkel, L. M. Conversion of mdx myofibres from dystrophin-negative to -positive by injection of normal myoblasts. Nature 337, 176\u2013179 (1989).","journal-title":"Nature"},{"key":"1190_CR41","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.ijgo.2011.11.029","volume":"117","author":"M Blaganje","year":"2012","unstructured":"Blaganje, M. & Lukanovi\u0107, A. Intrasphincteric autologous myoblast injections with electrical stimulation for stress urinary incontinence. Int. J. Gynaecol. Obstet. 117, 164\u2013167 (2012).","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"1190_CR42","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s00192-012-1963-0","volume":"24","author":"M Blaganje","year":"2013","unstructured":"Blaganje, M. & Lukanovi\u0107, A. Ultrasound-guided autologous myoblast injections into the extrinsic urethral sphincter: tissue engineering for the treatment of stress urinary incontinence. Int. Urogynecol. J. 24, 533\u2013535 (2013).","journal-title":"Int. Urogynecol. J."},{"key":"1190_CR43","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1093\/jnen\/62.9.951","volume":"62","author":"D Skuk","year":"2003","unstructured":"Skuk, D., Caron, N. J., Goulet, M., Roy, B. & Tremblay, J. P. Resetting the problem of cell death following muscle-derived cell transplantation: detection, dynamics and mechanisms. J. Neuropathol. Exp. Neurol. 62, 951\u2013967 (2003).","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"1190_CR44","doi-asserted-by":"publisher","first-page":"413","DOI":"10.2165\/00007256-200535050-00004","volume":"35","author":"GL Close","year":"2005","unstructured":"Close, G. L., Kayani, A., Vasilaki, A. & McArdle, A. Skeletal muscle damage with exercise and aging. Sports Med. 35, 413\u2013427 (2005).","journal-title":"Sports Med."},{"key":"1190_CR45","doi-asserted-by":"publisher","first-page":"5559","DOI":"10.1113\/jphysiol.2009.179515","volume":"587","author":"BK Pedersen","year":"2009","unstructured":"Pedersen, B. K. The diseasome of physical inactivity\u2013and the role of myokines in muscle\u2013fat cross talk. J. Physiol. 587, 5559\u20135568 (2009).","journal-title":"J. Physiol."},{"key":"1190_CR46","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/nrendo.2016.218","volume":"13","author":"MA Febbraio","year":"2017","unstructured":"Febbraio, M. A. Exercise metabolism in 2016: Health benefits of exercise - more than meets the eye! Nat. Rev. Endocrinol. 13, 72\u201374 (2017).","journal-title":"Nat. Rev. Endocrinol."},{"key":"1190_CR47","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-2-56","volume":"2","author":"D Nunan","year":"2013","unstructured":"Nunan, D., Mahtani, K. R., Roberts, N. & Heneghan, C. Physical activity for the prevention and treatment of major chronic disease: an overview of systematic reviews. Syst. Rev. 2, 56 (2013).","journal-title":"Syst. Rev."},{"key":"1190_CR48","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/s41574-019-0174-x","volume":"15","author":"BK Pedersen","year":"2019","unstructured":"Pedersen, B. K. Physical activity and muscle-brain crosstalk. Nat. Rev. Endocrinol. 15, 383\u2013392 (2019).","journal-title":"Nat. Rev. Endocrinol."},{"key":"1190_CR49","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.tins.2007.06.011","volume":"30","author":"CW Cotman","year":"2007","unstructured":"Cotman, C. W., Berchtold, N. C. & Christie, L. A. Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci. 30, 464\u2013472 (2007).","journal-title":"Trends Neurosci."},{"key":"1190_CR50","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.cmet.2012.08.012","volume":"16","author":"MP Mattson","year":"2012","unstructured":"Mattson, M. P. Energy intake and exercise as determinants of brain health and vulnerability to injury and disease. Cell Metab. 16, 706\u2013722 (2012).","journal-title":"Cell Metab."},{"key":"1190_CR51","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1152\/japplphysiol.00210.2011","volume":"111","author":"MW Voss","year":"2011","unstructured":"Voss, M. W., Nagamatsu, L. S., Liu-Ambrose, T. & Kramer, A. F. Exercise, brain, and cognition across the life span. J. Appl. Physiol. 111, 1505\u20131513 (2011).","journal-title":"J. Appl. Physiol."},{"key":"1190_CR52","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1056\/NEJMcp1800213","volume":"380","author":"RI Gafni","year":"2019","unstructured":"Gafni, R. I. & Collins, M. T. Hypoparathyroidism. New Engl. J. Med. 380, 1738\u20131747 (2019).","journal-title":"New Engl. J. Med."},{"key":"1190_CR53","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1210\/clinem\/dgaa113","volume":"105","author":"JP Bilezikian","year":"2020","unstructured":"Bilezikian, J. P. Hypoparathyroidism. J. Clin. Endocrinol. Metab. 105, 1722\u20131736 (2020).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"1190_CR54","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1002\/ajmg.a.40495","volume":"176","author":"A Rayannavar","year":"2018","unstructured":"Rayannavar, A. et al. Association of hypocalcemia with congenital heart disease in 22q11.2 deletion syndrome. Am. J. Med. Genet. A 176, 2099\u20132103 (2018).","journal-title":"Am. J. Med. Genet. A"},{"key":"1190_CR55","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.beem.2018.07.001","volume":"32","author":"L Cianferotti","year":"2018","unstructured":"Cianferotti, L., Marcucci, G. & Brandi, M. L. Causes and pathophysiology of hypoparathyroidism. Best Pract. Res. Clin. Endocrinol. Metab. 32, 909\u2013925 (2018).","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"1190_CR56","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1056\/NEJM199507273330407","volume":"333","author":"EM Brown","year":"1995","unstructured":"Brown, E. M. et al. Calcium-ion-sensing cell-surface receptors. N. Engl. J. Med. 333, 234\u2013240 (1995).","journal-title":"N. Engl. J. Med."},{"key":"1190_CR57","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1210\/endo-125-1-275","volume":"125","author":"T Naveh-Many","year":"1989","unstructured":"Naveh-Many, T., Friedlaender, M. M., Mayer, H. & Silver, J. Calcium regulates parathyroid hormone messenger ribonucleic acid (mRNA), but not calcitonin mRNA in vivo in the rat. Dominant role of 1,25-dihydroxyvitamin D. Endocrinology 125, 275\u2013280 (1989).","journal-title":"Endocrinology"},{"key":"1190_CR58","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1172\/JCI118224","volume":"96","author":"T Naveh-Many","year":"1995","unstructured":"Naveh-Many, T., Rahamimov, R., Livni, N. & Silver, J. Parathyroid cell proliferation in normal and chronic renal failure rats. The effects of calcium, phosphate, and vitamin D. J. Clini. Invest. 96, 1786\u20131793 (1995).","journal-title":"J. Clini. Invest."},{"key":"1190_CR59","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1007\/s00467-010-1565-3","volume":"25","author":"J Silver","year":"2010","unstructured":"Silver, J. & Naveh-Many, T. FGF23 and the parathyroid glands. Pediatr. Nephrol. 25, 2241\u20132245 (2010).","journal-title":"Pediatr. Nephrol."},{"key":"1190_CR60","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1002\/jbmr.3480","volume":"33","author":"RI Gafni","year":"2018","unstructured":"Gafni, R. I. et al. Hypocitraturia is an untoward side effect of synthetic human parathyroid hormone (hPTH) 1-34 therapy in hypoparathyroidism that may increase renal morbidity. J. Bone Miner. Res. 33, 1741\u20131747 (2018).","journal-title":"J. Bone Miner. Res."},{"key":"1190_CR61","doi-asserted-by":"publisher","first-page":"4507","DOI":"10.1210\/jc.2012-1808","volume":"97","author":"DM Mitchell","year":"2012","unstructured":"Mitchell, D. M. et al. Long-term follow-up of patients with hypoparathyroidism. J. Clin. Endocrinol. Metab. 97, 4507\u20134514 (2012).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"1190_CR62","first-page":"391","volume":"97","author":"KK Winer","year":"2012","unstructured":"Winer, K. K. et al. Synthetic human parathyroid hormone 1-34 replacement therapy: a randomized crossover trial comparing pump versus injections in the treatment of chronic hypoparathyroidism. J. Clin. Endocrinol. Metab. 97, 391\u2013399 (2012).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"1190_CR63","doi-asserted-by":"publisher","first-page":"103714","DOI":"10.1016\/j.drudis.2023.103714","volume":"28","author":"AS De Groot","year":"2023","unstructured":"De Groot, A. S. et al. Immunogenicity risk assessment of synthetic peptide drugs and their impurities. Drug Discov. Today 28, 103714 (2023).","journal-title":"Drug Discov. Today"},{"key":"1190_CR64","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1016\/j.ajpath.2018.04.016","volume":"188","author":"R Mazor","year":"2018","unstructured":"Mazor, R., King, E. M. & Pastan, I. Strategies to reduce the immunogenicity of recombinant immunotoxins. Am. J. Pathol. 188, 1736\u20131743 (2018).","journal-title":"Am. J. Pathol."},{"key":"1190_CR65","unstructured":"US Food and Drug Administration ANDAs for Certain Highly Purified Synthetic Peptide Drug Products That Refer to Listed Drugs of rDNA Origin https:\/\/www.fda.gov\/media\/107622\/download (2021)."},{"key":"1190_CR66","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/mp.2015.152","volume":"21","author":"M Notaras","year":"2016","unstructured":"Notaras, M., Hill, R., Gogos, J. A. & van den Buuse, M. BDNF Val66Met genotype determines hippocampus-dependent behavior via sensitivity to glucocorticoid signaling. Mol. Psychiatry 21, 730\u2013732 (2016).","journal-title":"Mol. Psychiatry"}],"container-title":["Nature Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s43587-026-01190-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s43587-026-01190-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s43587-026-01190-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:03:22Z","timestamp":1787735002000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s43587-026-01190-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":66,"alternative-id":["1190"],"URL":"https:\/\/doi.org\/10.1038\/s43587-026-01190-3","relation":{},"ISSN":["2662-8465"],"issn-type":[{"value":"2662-8465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,26]]},"assertion":[{"value":"29 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}