{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:38:18Z","timestamp":1740184698401,"version":"3.37.3"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Med"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background:<\/jats:title>\n                <jats:p>Takotsubo syndrome is characterized by transient regional systolic dysfunction, left ventricular (LV) dilatation, and edema, often occurring without obstructive coronary artery disease. The mechanisms underlying this stress-induced condition, especially the role of mechanical dyssynchrony in affecting systolic function, remain poorly understood.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods:<\/jats:title>\n                <jats:p>In our study, we evaluated global LV function and mechanical dyssynchrony in 24 Takotsubo patients compared to 20 controls by analyzing pressure-volume loops and time-varying elastance. Additionally, we monitored changes in LV segmental volume and internal flow.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results:<\/jats:title>\n                <jats:p>Here we show a significant reduction in global myocardial contractility and pronounced mechanical dyssynchrony in Takotsubo syndrome, particularly in the mid and apical LV segments, without disturbances in electrical conduction.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions:<\/jats:title>\n                <jats:p>Our findings reveal substantial mechanical dyssynchrony in Takotsubo patients, characterized by increased internal flow and a shortened systolic ejection time. This indicates a mechanical basis for the inefficient LV function in Takotsubo syndrome, independent of electrical conduction abnormalities.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1038\/s43856-024-00641-5","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T06:02:59Z","timestamp":1730440979000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regional mechanical dyssynchrony and shortened systole are present in people with Takotsubo syndrome"],"prefix":"10.1038","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1053-5175","authenticated-orcid":false,"given":"Jan-Christian","family":"Reil","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9192-7674","authenticated-orcid":false,"given":"Vasco","family":"Sequeira","sequence":"additional","affiliation":[]},{"given":"Gert-Hinrich","family":"Reil","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8454-4499","authenticated-orcid":false,"given":"Paul","family":"Steendijk","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3694-4559","authenticated-orcid":false,"given":"Christoph","family":"Maack","sequence":"additional","affiliation":[]},{"given":"Thomas","family":"Fink","sequence":"additional","affiliation":[]},{"given":"Elias","family":"Rawish","sequence":"additional","affiliation":[]},{"given":"Ingo","family":"Eitel","sequence":"additional","affiliation":[]},{"given":"Thomas","family":"Stiermaier","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,11,1]]},"reference":[{"key":"641_CR1","doi-asserted-by":"publisher","first-page":"H723","DOI":"10.1152\/ajpheart.00555.2003","volume":"286","author":"P Steendijk","year":"2004","unstructured":"Steendijk, P. et al. 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