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In\n                    <jats:italic>Kras<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>LSL-G12D\/WT<\/jats:italic>\n                    <\/jats:sup>\n                    <jats:italic>; p53<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>fl\/fl<\/jats:italic>\n                    <\/jats:sup>\n                    mouse models of lung adenocarcinoma (LUAD), TANs have an increased lifespan compared to normal neutrophils. Specifically, TANs upregulate the anti-apoptotic protein Bcl-xL, whose blockade by a BH3 mimetic selectively kills ageing TANs and diminishes tumor growth. Here, we have addressed this issue in lung squamous cell carcinoma (LUSC) using the\n                    <jats:italic>Rosa26<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>LSL-Sox2-IRES-GFP<\/jats:italic>\n                    <\/jats:sup>\n                    <jats:italic>; Nkx2-1<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>fl\/fl<\/jats:italic>\n                    <\/jats:sup>\n                    <jats:italic>; Lkb1<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>fl\/fl<\/jats:italic>\n                    <\/jats:sup>\n                    mouse model, where we demonstrate increased TAN survival with a rise in Bcl-xL similarly to LUAD. However, unlike in LUAD, inhibiting Bcl-xL alone was insufficient to alter tumor progression in LUSC. After carboplatin and paclitaxel treatment, a combination chemotherapy used in human LUSC, we detected increased neutrophils in circulation, spleen and tumors, and increased Bcl-xL in neutrophils and TANs. Bcl-xL blockade decreased the pool of Bcl-xL-high TANs and synergized with chemotherapy. Altogether, our results suggest distinct outcomes for targeting TANs in different tumor types and reinforce the concept of repurposing BH3 mimetics against cancer.\n                  <\/jats:p>","DOI":"10.1038\/s44321-026-00401-z","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T11:12:46Z","timestamp":1774955566000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bcl-xL blockade targets neutrophils and synergizes with chemotherapy in lung squamous cell carcinoma"],"prefix":"10.1038","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0697-1203","authenticated-orcid":false,"given":"Abdullah","family":"Mayet","sequence":"first","affiliation":[]},{"given":"Beatrice","family":"Parma","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1075-9964","authenticated-orcid":false,"given":"D\u00e9borah","family":"L\u00e9cuyer","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5512-9936","authenticated-orcid":false,"given":"Amaury","family":"Defruit","sequence":"additional","affiliation":[]},{"given":"Sarika","family":"Rana","sequence":"additional","affiliation":[]},{"given":"Anita","family":"Bodac","sequence":"additional","affiliation":[]},{"given":"Pieter","family":"Demetter","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7985-716X","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Denanglaire","sequence":"additional","affiliation":[]},{"given":"Abbie S","family":"Ireland","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1653-3544","authenticated-orcid":false,"given":"Mariana","family":"Brand\u00e3o","sequence":"additional","affiliation":[]},{"given":"Thierry","family":"Berghmans","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8644-1020","authenticated-orcid":false,"given":"Fabienne","family":"Andris","sequence":"additional","affiliation":[]},{"given":"Stanislas","family":"Goriely","sequence":"additional","affiliation":[]},{"given":"Jean Yannis","family":"Perentes","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2082-2397","authenticated-orcid":false,"given":"Trudy G","family":"Oliver","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0899-2230","authenticated-orcid":false,"given":"Etienne","family":"Meylan","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"401_CR1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao4227","volume":"361","author":"J Albrengues","year":"2018","unstructured":"Albrengues J, Shields MA, Ng D, Park CG, Ambrico A, Poindexter ME, Upadhyay P, Uyeminami DL, Pommier A, K\u00fcttner V et al (2018) Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. 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