{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:52:41Z","timestamp":1761511961698},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2004,7,6]],"date-time":"2004-07-06T00:00:00Z","timestamp":1089072000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2004,8]]},"DOI":"10.1038\/sj.bjc.6601989","type":"journal-article","created":{"date-parts":[[2004,7,7]],"date-time":"2004-07-07T01:36:19Z","timestamp":1089164179000},"page":"732-738","source":"Crossref","is-referenced-by-count":49,"title":["Underexpression of peroxisome proliferator-activated receptor (PPAR)\u03b3 in PAX8\/PPAR\u03b3-negative thyroid tumours"],"prefix":"10.1038","volume":"91","author":[{"given":"A R","family":"Marques","sequence":"first","affiliation":[]},{"given":"C","family":"Espadinha","sequence":"additional","affiliation":[]},{"given":"M J","family":"Frias","sequence":"additional","affiliation":[]},{"given":"L","family":"Roque","sequence":"additional","affiliation":[]},{"given":"A L","family":"Catarino","sequence":"additional","affiliation":[]},{"given":"L G","family":"Sobrinho","sequence":"additional","affiliation":[]},{"given":"V","family":"Leite","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2004,7,6]]},"reference":[{"key":"BF6601989_CR1","doi-asserted-by":"publisher","first-page":"3412","DOI":"10.1038\/sj.onc.1206400","volume":"22","author":"MA Aldred","year":"2003","unstructured":"Aldred MA, Morrison C, Gimm O, Hoang-Vu C, Krause U, Dralle H, Jhiang S, Eng C (2003) Peroxisome proliferator-activated receptor gamma is frequently downregulated in a diversity of sporadic nonmedullary thyroid carcinomas. Oncogene 22: 3412\u20133416, doi: 10.1038\/sj.onc.1206400","journal-title":"Oncogene"},{"key":"BF6601989_CR2","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/S0016-5085(98)70072-1","volume":"115","author":"JA Brockman","year":"1998","unstructured":"Brockman JA, Gupta RA, DuBois RN (1998) Activation of PPAR\u03b3 leads to inhibition of anchorage-independent growth of human colorectal cancer cells. Gastroenterology 115: 1049\u20131055","journal-title":"Gastroenterology"},{"key":"BF6601989_CR3","first-page":"1129","volume":"60","author":"T Chang","year":"2000","unstructured":"Chang T, Szabo E (2000) Induction of differentiation and apoptosis by ligands of peroxisome proliferator-activated receptor \u03b3 in non-small cell lung cancer. Cancer Res 60: 1129\u20131138","journal-title":"Cancer Res"},{"key":"BF6601989_CR4","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1073\/pnas.91.5.1786","volume":"91","author":"A Chawla","year":"1994","unstructured":"Chawla A, Lazar MA (1994) Peroxisome proliferator and retinoid signaling pathways co-regulate preadipocyte phenotype and survival. Proc Natl Acad Sci USA 91: 1786\u20131790","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6601989_CR5","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1210\/jc.2002-021020","volume":"88","author":"L Cheung","year":"2003","unstructured":"Cheung L, Messina M, Gill A, Clarkson A, Learoyd D, Delbridge L, Wentworth J, Philips J, Clifton-Bligh R, Robinson BG (2003) Detection of the PAX8-PPAR\u03b3 fusion oncogene in both follicular thyroid carcinomas and adenomas. J Clin Endocrinol Metab 88: 354\u2013357, doi: 10.1210\/jc.2002-021020.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF6601989_CR6","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1210\/jcem-71-2-414","volume":"71","author":"LJ DeGroot","year":"1990","unstructured":"DeGroot LJ, Kaplan EL, McCormick M, Straus FH (1990) Natural History, treatment, and course of papillary thyroid carcinoma. J Clin Endocrinol Metab 71: 414\u2013424","journal-title":"J Clin Endocrinol Metab"},{"key":"BF6601989_CR7","doi-asserted-by":"publisher","first-page":"3951","DOI":"10.1073\/pnas.96.7.3951","volume":"96","author":"GD Demetri","year":"1999","unstructured":"Demetri GD, Fletcher CDM, Mueller E, Sarraf P, Naujoks R, Campbell N, Spiegelman B, Singer S (1999) Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-\u03b3 ligand troglitazone in patients with liposarcoma. Proc Natl Acad Sci USA 96: 3951\u20133956","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6601989_CR8","first-page":"649","volume":"20","author":"B Desvergne","year":"1999","unstructured":"Desvergne B, Wahli W (1999) Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 20: 649\u2013688","journal-title":"Endocr Rev"},{"key":"BF6601989_CR9","doi-asserted-by":"publisher","first-page":"8806","DOI":"10.1073\/pnas.95.15.8806","volume":"95","author":"E Elstner","year":"1998","unstructured":"Elstner E, Mueller C, Koshizuka K, Williamson EA, Park D, Asou H, Shintaku P, Said JW, Heber D, Koeffler HP (1998) Ligands for peroxisome proliferator-activated receptor-\u03b3 and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc Natl Acad Sci USA 95: 8806\u20138811","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6601989_CR10","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/0092-8674(95)90193-0","volume":"83","author":"BM Forman","year":"1995","unstructured":"Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM (1995) 15-Deoxy-\u039412,14 prostaglandin J2 is a ligand for the adipocyte determination factor PPAR\u03b3. Cell 83: 803\u2013812","journal-title":"Cell"},{"key":"BF6601989_CR11","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/S0002-9440(10)63902-8","volume":"162","author":"CA French","year":"2003","unstructured":"French CA, Alexander EK, Cibas ES, Nose V, Laguette J, Faquin W, Garber J, Moore Jr F, Fletcher JA, Larsen PR, Kroll TG (2003) Genetic and biological subgroups of low-stage follicular thyroid cancer. Am J Pathol 162: 1053\u20131060","journal-title":"Am J Pathol"},{"key":"BF6601989_CR12","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/sj.neo.7900050","volume":"1","author":"YF Guan","year":"1999","unstructured":"Guan YF, Zhang YH, Breyer RM, Davis L, Breyer MD 1999 Expression of peroxisome proliferator-activated receptor gamma (PPAR gamma) in human transitional bladder cancer and its role in inducing cell death. Neoplasia 1: 330\u2013339","journal-title":"Neoplasia"},{"key":"BF6601989_CR13","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/S0090-4295(02)01747-8","volume":"60","author":"T Hase","year":"2002","unstructured":"Hase T, Yoshimura R, Mitsuhashi M, Segawa Y, Kawashito Y, Wada S, Nakatani T, Sano H (2002) Expression of peroxisome proliferator-activated receptors in human testicular cancer and growth inhibition by its agonists. Urology 60: 542\u2013547","journal-title":"Urology"},{"key":"BF6601989_CR14","first-page":"1050","volume":"114","author":"ID Hay","year":"1993","unstructured":"Hay ID, Bergstralh EJ, Goellner JR, Ebersold JR, Grant, CS (1993) Predicting outcome in papillary thyroid carcinoma: development of a reliable prognostic scoring system in a cohort of 1779 patients surgically treated at one institution during 1940 through 1989. Surgery 114: 1050\u20131058","journal-title":"Surgery"},{"key":"BF6601989_CR15","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1006\/bbrc.2001.5640","volume":"287","author":"K Inoue","year":"2001","unstructured":"Inoue K, Kawashito Y, Tsubouchi Y, Kohno M, Yoshimura R, Yoshikawa T, Sano H 2001 Expression of peroxisome proliferator-activated receptor \u03b3 in renal cell carcinoma and growth inhibition by its agonists. Biochem Biophys Res Commun 287: 727\u2013732","journal-title":"Biochem Biophys Res Commun"},{"key":"BF6601989_CR16","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/j.1349-7006.1999.tb00668.x","volume":"90","author":"S Kitamura","year":"1999","unstructured":"Kitamura S, Miyazaki Y, Shinomura Y, Kondo S, Kanayama S, Matsuzawa Y (1999) Peroxisome proliferator-activated receptor gamma induces growth arrest and differentiation markers of human colon cancer cells. Jpn J Cancer Res 90: 75\u201380","journal-title":"Jpn J Cancer Res"},{"key":"BF6601989_CR17","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/0092-8674(95)90194-9","volume":"83","author":"SA Kliewer","year":"1995","unstructured":"Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, Lehman JM (1995) A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell 83: 813\u2013819","journal-title":"Cell"},{"key":"BF6601989_CR18","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1126\/science.289.5483.1357","volume":"289","author":"TG Kroll","year":"2000","unstructured":"Kroll TG, Sarraf P, Pecciarini L, Chen C, Mueller E, Spiegelman BM, Fletcher JA (2000) PAX8-PPAR\u03b31 fusion oncogene in human thyroid carcinoma. Science 289: 1357\u20131360","journal-title":"Science"},{"key":"BF6601989_CR19","first-page":"3344","volume":"58","author":"T Kubota","year":"1998","unstructured":"Kubota T, Koshizika K, Williamson EA, Asou H, Said JW, Holden S, Miyoshi I, Koeffler HP (1998) Ligand for peroxisome proliferator-activated receptor \u03b3 (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo. Cancer Res 58: 3344\u20133352","journal-title":"Cancer Res"},{"key":"BF6601989_CR20","first-page":"3228","volume":"84","author":"V Lazar","year":"1999","unstructured":"Lazar V, Bidart JM, Caillou B, Mah\u00e9 C, Lacroix L, Filetti S, Schumberger M (1999) Expression of the Na+\/I\u2212 symporter gene in human thyroid tumors: a comparison study with other thyroid-specific genes. J Clin Endocrinol Metab 84: 3228\u20133234","journal-title":"J Clin Endocrinol Metab"},{"key":"BF6601989_CR21","doi-asserted-by":"publisher","first-page":"12953","DOI":"10.1074\/jbc.270.22.12953","volume":"270","author":"JM Lehmann","year":"1995","unstructured":"Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer AS (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor \u03b3 (PPAR \u03b3). J Biol Chem 270: 12953\u201312956","journal-title":"J Biol Chem"},{"key":"BF6601989_CR22","first-page":"3947","volume":"87","author":"AR Marques","year":"2002","unstructured":"Marques AR, Espadinha C, Catarino AL, Moniz S, Pereira T, Sobrinho LG, Leite V (2002) Expression of PAX8-PPAR\u03b31 rearrangements in both follicular thyroid carcinomas and adenomas. J Clin Endocrinol Metab 87: 3947\u20133952","journal-title":"J Clin Endocrinol Metab"},{"key":"BF6601989_CR23","doi-asserted-by":"publisher","first-page":"4728","DOI":"10.1210\/jc.2001-012054","volume":"87","author":"ML Martelli","year":"2002","unstructured":"Martelli ML, Iuliano R, Le Pera I, Sama I, Monaco C, Cammarota S, Kroll T, Chiariotti L, Santoro M, Fusco A (2002) Inhibitory effects of peroxisome proliferator-activated receptor \u03b3 on thyroid carcinoma cell growth. J Clin Endocrinol Metab 87: 4728\u20134735, doi: 10.1210\/jc.2001-012054","journal-title":"J Clin Endocrinol Metab"},{"key":"BF6601989_CR24","doi-asserted-by":"publisher","first-page":"S75","DOI":"10.1016\/S0021-9150(97)00315-8","volume":"137","author":"G Martin","year":"1998","unstructured":"Martin G, Schoonjans K, Staels B, Auwerx J (1998) PPAR-gamma activators improve glucose homeostasis by stimulating fatty acid uptake in the adipocytes. Atherosclerosis 137: S75\u2013S80","journal-title":"Atherosclerosis"},{"key":"BF6601989_CR25","first-page":"5558","volume":"60","author":"W Motomura","year":"2000","unstructured":"Motomura W, Okumur T, Takahashi N, Obara T, Kohgo Y (2000) Activation of peroxisome proliferator-activated receptor gamma by troglitazone inhibits cell growth through the increase of p27 Kip1 in human pancreatic carcinoma cells. Cancer Res 60: 5558\u20135564","journal-title":"Cancer Res"},{"key":"BF6601989_CR26","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/S1097-2765(00)80047-7","volume":"1","author":"E Mueller","year":"1998","unstructured":"Mueller E, Sarraf P, Tontonoz P, Evans RM, Martin KJ, Zhang M, Fletcher C, Singer S, Spiegeman BM (1998) Terminal differentiation of human breast cancer through PPAR-gamma. Mol Cell 1: 465\u2013470","journal-title":"Mol Cell"},{"key":"BF6601989_CR27","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1097\/00000478-200208000-00006","volume":"26","author":"MN Nikiforova","year":"2002","unstructured":"Nikiforova MN, Biddinger PW, Caudill CM, Kroll TG, Nikiforov YE (2002) PAX8-PPAR\u03b3 rearrangement in thyroid tumors \u2013 RT\u2013PCR and immunohistochemical analysis. Am J Surg Pathol 26: 1016\u20131023, doi: 10.1097\/01.PAS.0000021228.30983.6A","journal-title":"Am J Surg Pathol"},{"key":"BF6601989_CR28","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1210\/jc.2002-021907","volume":"88","author":"MN Nikiforova","year":"2003","unstructured":"Nikiforova MN, Lynch RA, Biddinger PW, Alexander EK, Dorn II GW, Tallini G, Kroll TG, Nikiforov YE (2003) RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma. J Clin Endocrinol Metab 88: 2318\u20132326, doi: 10.1210\/jc.2002-021907","journal-title":"J Clin Endocrinol Metab"},{"key":"BF6601989_CR29","first-page":"2170","volume":"86","author":"K Ohta","year":"2001","unstructured":"Ohta K, Endo T, Haraguchi K, Hershman JM, Onaya T (2001) Ligands for peroxisome proliferator-activated receptor \u03b3 inhibit growth and induce apoptosis of human papillary thyroid carcinoma cells. J Clin Endocrinol Metab 86: 2170\u20132177","journal-title":"J Clin Endocrinol Metab"},{"key":"BF6601989_CR30","doi-asserted-by":"publisher","first-page":"37731","DOI":"10.1074\/jbc.R100034200","volume":"276","author":"ED Rosen","year":"2001","unstructured":"Rosen ED, Spiegelman BM (2001) PPAR\u03b3: a nuclear regulator of metabolism, differentiation and cell growth. J Biol Chem 276: 37731\u201337734, doi: 10.1074\/jbc.R100034200","journal-title":"J Biol Chem"},{"key":"BF6601989_CR31","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1038\/2030","volume":"4","author":"P Sarraf","year":"1998","unstructured":"Sarraf P, Mueller E, Jones D, King FJ, DeAngelo DJ, Partridge JB, Holden SA, Chen LB, Singer S, Fletcher C, Spiegelman BM (1998) Differentiation and reversal of malignant changes in colon cancer through PPAR\u03b3. Nat Med 4: 1046\u20131052","journal-title":"Nat Med"},{"key":"BF6601989_CR32","first-page":"799","volume":"3","author":"P Sarraf","year":"1999","unstructured":"Sarraf P, Mueller E, Smith WM, Wright HM, Kum JB, Aaltonen LA, de la Chapelle A, Spiegelman BM, Eng C (1999) Loss-of-function mutations in PPAR\u03b3 associated with human colon cancer. Cell 3: 799\u2013804","journal-title":"Cell"},{"key":"BF6601989_CR33","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1054\/bjoc.2000.1457","volume":"83","author":"H Sato","year":"2000","unstructured":"Sato H, Ishihara S, Kawashima K, Moriyama N, Suetsugu H, Kazumori H, Okuyama T, Rumi MA, Fukuda R, Nagasue N, Kinoshita Y (2000) Expression of peroxisome proliferator-activated receptor (PPAR) gamma in gastric cancer and inhibitory effects of PPAR gamma agonists. Br J Cancer 83: 1394\u20131400","journal-title":"Br J Cancer"},{"key":"BF6601989_CR34","first-page":"4116","volume":"83","author":"SL Sugg","year":"1998","unstructured":"Sugg SL, Ezzat S, Rosen IB, Freeman JL, Asa SL (1998) Distinct multiple RET\/PTC gene rearrangements in multifocal papillary thyroid neoplasia. J Clin Endocrinol Metab 83: 4116\u20134122","journal-title":"J Clin Endocrinol Metab"},{"key":"BF6601989_CR35","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1006\/bbrc.2001.5602","volume":"287","author":"H Sundvold","year":"2001","unstructured":"Sundvold H, Lien S (2001) Identification of a novel peroxisome proliferator-activated receptor (PPAR) gamma promoter in man and transactivation by the nuclear receptor ROR alpha 1. Biochem Biophys Res Commun 287: 383\u2013390","journal-title":"Biochem Biophys Res Commun"},{"key":"BF6601989_CR36","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1093\/jjco\/hyf056","volume":"32","author":"Y Terashita","year":"2002","unstructured":"Terashita Y, Sasaki H, Haruki N, Nishiwaki T, Ishiguro H, Shibata Y, Kudo J, Konishi S, Kato J, Koyama H, Kimura M, Sato A, Shinoda N, Kuwabara Y, Fujii Y (2002) Decreased peroxisome proliferator-activated receptor gamma gene expression is correlated with poor prognosis in patients with esophageal cancer. Jpn J Clin Oncol 32: 238\u2013243","journal-title":"Jpn J Clin Oncol"},{"key":"BF6601989_CR37","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1101\/gad.8.10.1224","volume":"8","author":"P Tontonoz","year":"1994","unstructured":"Tontonoz P, Hu E, Graves RA, Buclavari AI, Spiegelman BM (1994) mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev 8: 1224\u20131234","journal-title":"Genes Dev"},{"key":"BF6601989_CR38","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1073\/pnas.94.1.237","volume":"94","author":"P Tontonoz","year":"1997","unstructured":"Tontonoz P, Singer S, Forman BM, Sarraf P, Fletcher JA, Fletcher CDM, Brun RP, Mueller E, Altiok S, Oppenheim H, Evans RM, Spiegelman BM (1997) Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor \u03b3 and the retinoid X receptor. Proc Natl Acad Sci USA 94: 237\u2013241","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6601989_CR39","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1136\/gut.50.4.563","volume":"50","author":"M Toyoda","year":"2002","unstructured":"Toyoda M, Takagi H, Noriguchi N, Kakizaki S, Sato H, Takayama H, Mori M (2002) A ligand for peroxisome proliferator activated receptor \u03b3 inhibits cell growth and induces apoptosis in human liver cancer cells. Gut 50: 563\u2013567","journal-title":"Gut"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6601989.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6601989","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6601989.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:10:24Z","timestamp":1684411824000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6601989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7,6]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,8]]}},"alternative-id":["BF6601989"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjc.6601989","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7,6]]}}}