{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T22:42:04Z","timestamp":1769812924941,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T00:00:00Z","timestamp":1233792000000},"content-version":"vor","delay-in-days":4175,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1997,9]]},"abstract":"I<\/jats:italic>Ks<\/jats:sub> channels are composed of I<\/jats:italic>sK<\/jats:sub> and KvLQT1 subunits and underly the slowly activating, voltage\u2010dependent I<\/jats:italic>Ks<\/jats:sub> conductance in heart. Although it appears clear that the I<\/jats:italic>sK<\/jats:sub> protein affects both the biophysical properties and regulation of I<\/jats:italic>Ks<\/jats:sub> channels, its role in channel pharmacology is unclear. In the present study we demonstrate that KvLQT1 homopolymeric K+<\/jats:sup> channels are inhibited by the I<\/jats:italic>Ks<\/jats:sub> blockers 293B, azimilide and 17\u2010\u03b2\u2010oestradiol. However, I<\/jats:italic>Ks<\/jats:sub> channels induced by the coexpression of I<\/jats:italic>sK<\/jats:sub> and KvLQT1 subunits have a 6\u2013100 fold higher affinity for these blockers. Moreover, the I<\/jats:italic>Ks<\/jats:sub> activators mefenamic acid and DIDS had little effect on KvLQT1 homopolymeric channels, although they dramatically enhanced steady\u2010state currents through heteropolymeric I<\/jats:italic>Ks<\/jats:sub> channels by arresting them in an open state. In summary, the I<\/jats:italic>sK<\/jats:sub> protein modulates the effects of both blockers and activators of I<\/jats:italic>Ks<\/jats:sub> channels. This finding is important for the action and specificity of these drugs as I<\/jats:italic>sK<\/jats:sub> protein expression in heart and other tissues is regulated during development and by hormones.<\/jats:p>British Journal of Pharmacology<\/jats:italic> (1997) 122<\/jats:bold>, 187\u2013189; doi:10.1038\/sj.bjp.0701434<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0701434","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T19:14:01Z","timestamp":1106939641000},"page":"187-189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["The role of the I<\/i>sK<\/sub> protein in the specific pharmacological properties of the I<\/i>Ks<\/sub> channel complex"],"prefix":"10.1111","volume":"122","author":[{"given":"A. 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