{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:13:51Z","timestamp":1761862431448},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":2469,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Interactions between A<jats:sub>2A<\/jats:sub>\u2010adenosine receptors and \u03b1<jats:sub>2<\/jats:sub>\u2010, A<jats:sub>1<\/jats:sub>\u2010 and P2\u2010 release\u2010inhibitory receptors, on the modulation of noradrenaline release were studied in isolated rat tail artery. Preparations were labelled with [<jats:sup>3<\/jats:sup>H]\u2010noradrenaline, superfused with desipramine\u2010containing medium, and stimulated electrically (100 pulses at 5\u2003Hz or 20 pulses at 50\u2003Hz).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Blockade of \u03b1<jats:sub>2<\/jats:sub>\u2010autoreceptors with yohimbine (1\u2003\u03bc<jats:sc>M<\/jats:sc>) increased tritium overflow elicited by 100 pulses at 5\u2003Hz but not by 20 pulses at 50\u2003Hz.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The selective A<jats:sub>2A<\/jats:sub>\u2010receptor agonist 2\u2010<jats:italic>p<\/jats:italic>\u2010(2\u2010carboxyethyl)phenethylamino\u20105\u2032\u2010N\u2010ethylcarboxamidoadenosine (CGS 21680; 1\u2003\u2013\u2003100\u2003n<jats:sc>M<\/jats:sc>) enhanced tritium overflow elicited by 100 pulses at 5\u2003Hz. Yohimbine prevented the effect of CGS 21680, which was restored by the A<jats:sub>1<\/jats:sub>\u2010receptor agonist N<jats:sup>6<\/jats:sup>\u2010cyclopentyladenosine (CPA; 100\u2003n<jats:sc>M<\/jats:sc>) or by the P2\u2010receptor agonist 2\u2010methylthioadenosine triphosphate (2\u2010MeSATP; 80\u2003\u03bc<jats:sc>M<\/jats:sc>).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>CGS 21680 (100\u2003n<jats:sc>M<\/jats:sc>) failed to increase tritium overflow elicited by 20 pulses at 50\u2003Hz. The \u03b1<jats:sub>2<\/jats:sub>\u2010adrenoceptor agonist 5\u2010bromo\u20106\u2010(2\u2010imidazolin\u20102\u2010ylamino)\u2010quinoxaline (UK 14304; 30\u2003n<jats:sc>M<\/jats:sc>), the A<jats:sub>1<\/jats:sub>\u2010receptor agonist CPA (100\u2003n<jats:sc>M<\/jats:sc>) or the P2\u2010receptor agonist 2\u2010MeSATP (80\u2003\u03bc<jats:sc>M<\/jats:sc>) reduced tritium overflow. In the presence of these agonists CGS 21680 elicited a facilitation of tritium overflow.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Blockade of potassium channels with tetraethylammonium (TEA; 5\u2003m<jats:sc>M<\/jats:sc>) increased tritium overflow elicited by 100 pulses at 5\u2003Hz to values similar to those obtained in the presence of yohimbine but did not prevent the effect of CGS 21680 (100\u2003n<jats:sc>M<\/jats:sc>) on tritium overflow.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>It is concluded that, in isolated rat tail artery, the facilitation of noradrenaline release mediated by A<jats:sub>2A<\/jats:sub>\u2010adenosine receptors is favoured by activation of release inhibitory receptors.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2002) <jats:bold>136<\/jats:bold>, 230\u2013236; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0704686\">10.1038\/sj.bjp.0704686<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0704686","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:54:48Z","timestamp":1106949288000},"page":"230-236","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Release inhibitory receptors activation favours the A<sub>2A<\/sub>\u2010adenosine receptor\u2010mediated facilitation of noradrenaline release in isolated rat tail artery"],"prefix":"10.1111","volume":"136","author":[{"given":"Paula","family":"Fresco","sequence":"first","affiliation":[]},{"given":"Carmen","family":"Diniz","sequence":"additional","affiliation":[]},{"given":"Gl\u00f3ria","family":"Queiroz","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2009,2,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1987.tb08970.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00175467"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(88)90238-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb14777.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1991.tb09836.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1988.tb11730.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703167"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005355"},{"key":"e_1_2_7_10_1","first-page":"114P","article-title":"Influence of \u03b12\u2010autoreceptor blockade on the A2A\u2010mediated facilitation of noradrenaline release in rat isolated tail artery","volume":"127","author":"DINIZ C.","year":"1999","journal-title":"Br. 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