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The K<jats:sup>+<\/jats:sup> channel opener pinacidil increased the amphotericin B\u2010induced <jats:italic>I<\/jats:italic><jats:sub>K<\/jats:sub>. The selective D<jats:sub>2<\/jats:sub>\u2010like receptor agonist quinerolane increased, in a concentration dependent manner (EC<jats:sub>50<\/jats:sub>=136 n<jats:sc>M<\/jats:sc>), <jats:italic>I<\/jats:italic><jats:sub>K<\/jats:sub> across the basolateral membrane, this effect being abolished by pre\u2010treatment with pertussis toxin (PTX), S\u2010sulpiride (selective D<jats:sub>2<\/jats:sub>\u2010like receptor antagonist) and glibenclamide. The selective D<jats:sub>1<\/jats:sub>\u2010like receptor agonist SKF 38393 did not change <jats:italic>I<\/jats:italic><jats:sub>K<\/jats:sub>. Both H\u201089 (PKA inhibitor) and chelerythrine (PKC inhibitor) failed to prevent the stimulatory effect of quinerolane upon <jats:italic>I<\/jats:italic><jats:sub>K<\/jats:sub>.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Quinerolane did not change basal levels of cyclic AMP and also failed to affect the forskolin\u2010induced increase in cyclic AMP levels.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The stimulation of D<jats:sub>2<\/jats:sub>\u2010like receptor was associated with a rapid hyperpolarizing effect, whereas D<jats:sub>1<\/jats:sub>\u2010like receptor activation was accompanied by increases in cell membrane potential. The hyperpolarizing effect of quinerolane (EC<jats:sub>50<\/jats:sub>=129 n<jats:sc>M<\/jats:sc>) was prevented by pre\u2010treatment with PTX, S\u2010sulpiride and glibenclamide.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>It is concluded that stimulation of dopamine D<jats:sub>2<\/jats:sub>\u2010like, but not D<jats:sub>1<\/jats:sub>\u2010like, receptors coupled to PTX\u2010sensitive G proteins of the G<jats:sub>i\/o<\/jats:sub> class produce membrane hyperpolarization through opening of K<jats:sub>ATP<\/jats:sub> channels.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2003) <jats:bold>138<\/jats:bold>, 968\u2013976. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0705125\">10.1038\/sj.bjp.0705125<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0705125","type":"journal-article","created":{"date-parts":[[2003,3,17]],"date-time":"2003-03-17T18:23:15Z","timestamp":1047925395000},"page":"968-976","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Dopamine D<sub>2<\/sub>\u2010like receptor\u2010mediated opening of K<sup>+<\/sup> channels in opossum kidney cells"],"prefix":"10.1111","volume":"138","author":[{"given":"Pedro","family":"Gomes","sequence":"first","affiliation":[]},{"given":"Patr\u00edcio","family":"Soares\u2010da\u2010Silva","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2009,1,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01119474"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/72929"},{"key":"e_1_2_7_4_1","first-page":"R1561","article-title":"Stimulation of Na(+)\u2010K(+)\u20102Cl\u2010 cotransport in rat medullary thick ascending limb by dopamine","volume":"271","author":"AOKI Y.","year":"1996","journal-title":"Am. 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