{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T05:18:06Z","timestamp":1736227086402,"version":"3.32.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T00:00:00Z","timestamp":1233273600000},"content-version":"vor","delay-in-days":1066,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p><jats:list list-type=\"explicit-label\"><jats:list-item><jats:p>Acute effects of angiotensin II (AngII) on diastolic properties of the myocardium were investigated.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>Increasing concentrations of AngII (10<jats:sup>\u22129<\/jats:sup>to 10<jats:sup>\u22125<\/jats:sup>\u2003<jats:sc>M<\/jats:sc>) were added to rabbit papillary muscles in the absence (<jats:italic>n<\/jats:italic>=11) or presence of: (i) AT1 receptor antagonists, losartan (10<jats:sup>\u22126<\/jats:sup>\u2003<jats:sc>M<\/jats:sc>;<jats:italic>n<\/jats:italic>=7) or ZD\u20107155 (10<jats:sup>\u22127<\/jats:sup>\u2003<jats:sc>M<\/jats:sc>;<jats:italic>n<\/jats:italic>=8); (ii) ZD\u20107155 (10<jats:sup>\u22127<\/jats:sup>\u2003<jats:sc>M<\/jats:sc>) plus AT2 receptor antagonist PD\u2010123,319 (2 \u00d7 10<jats:sup>\u22126<\/jats:sup>\u2003<jats:sc>M<\/jats:sc>;<jats:italic>n<\/jats:italic>=6); (iii) PKC inhibitor, chelerythrine (10<jats:sup>\u22125<\/jats:sup>\u2003<jats:sc>M<\/jats:sc>;<jats:italic>n<\/jats:italic>=8); or (iv) Na<jats:sup>+<\/jats:sup>\/H<jats:sup>+<\/jats:sup>exchanger (NHE) inhibitor, 5\u2010(<jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:italic>N<\/jats:italic>\u2010isobutyl)\u2010amiloride (10<jats:sup>\u22126<\/jats:sup>\u2003<jats:sc>M<\/jats:sc>;<jats:italic>n<\/jats:italic>=10). Passive length\u2013tension relations were constructed before and after a single concentration of AngII (10<jats:sup>\u22125<\/jats:sup>\u2003<jats:sc>M<\/jats:sc>,<jats:italic>n<\/jats:italic>=6). Effects of AngII infusion (10\u2003<jats:italic>\u03bc<\/jats:italic>g\u2003kg<jats:sup>\u22121<\/jats:sup>\u2003min<jats:sup>\u22121<\/jats:sup>) were evaluated in<jats:italic>in situ<\/jats:italic>rabbit hearts.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>AngII concentration dependently increased inotropy and resting muscle length (RL). At 10<jats:sup>\u22125<\/jats:sup>\u2003<jats:sc>M<\/jats:sc>, active tension increased 43.3\u00b16.25% and RL 1.96\u00b10.4%. Correcting RL to its initial value resulted in a 46\u00b14% decrease of resting tension, indicating decreased muscle stiffness, as confirmed by the right and downward shift of the passive length\u2013tension relation promoted by AngII. In the intact heart, at matched systolic pressures of 112\u2003mmHg, AngII decreased end\u2010diastolic pressures from 10.3\u00b10.3 to 5.9\u00b10.5\u2003mmHg, and minimal diastolic pressures from 8.4\u00b10.5 to 4.6\u00b10.6\u2003mmHg.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>AT1 blockade inhibited AngII effects on myocardial inotropy and stiffness, while PKC or NHE inhibition only significantly attenuated its effects on resting length and tension.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>In conclusion, AngII decreases myocardial stiffness, an effect that requires AT1 receptor activation and is mediated by PKC and NHE. This represents a novel mechanism of acute neurohumoral modulation of diastolic function, suggesting that AngII is a powerful regulator of cardiac filling.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic>(2006)<jats:bold>147<\/jats:bold>, 690\u2013697. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0706659\">10.1038\/sj.bjp.0706659<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0706659","type":"journal-article","created":{"date-parts":[[2006,1,16]],"date-time":"2006-01-16T13:58:04Z","timestamp":1137419884000},"page":"690-697","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na<sup>+<\/sup>\/H<sup>+<\/sup>exchanger\u2010mediated effect"],"prefix":"10.1111","volume":"147","author":[{"given":"Adelino F","family":"Leite\u2010Moreira","sequence":"first","affiliation":[]},{"given":"Paulo","family":"Castro\u2010Chaves","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Pimentel\u2010Nunes","sequence":"additional","affiliation":[]},{"given":"Alexandre","family":"Lima\u2010Carneiro","sequence":"additional","affiliation":[]},{"given":"Miguel S","family":"Guerra","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o Bruno","family":"Soares","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o","family":"Ferreira\u2010Martins","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2009,1,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1975.tb01449.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.4.H1528"},{"issue":"11","key":"e_1_2_6_4_1","first-page":"S23","article-title":"Localization of angiotensin AT1 and AT2 receptors","volume":"10","author":"ALLEN A.M.","year":"1999","journal-title":"J. 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