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The rank order of potency for nicotinic ACh receptor antagonists that inhibit adenosine release was DH<jats:italic>\u03b2<\/jats:italic>E&gt;mecamylamine&gt;<jats:sc>D<\/jats:sc>\u2010tubocurarine&gt;<jats:italic>\u03b1<\/jats:italic>\u2010bungarotoxin.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The effect of the endogenous agonist, ACh, which was mimicked by nicotine, was antagonized by DH<jats:italic>\u03b2<\/jats:italic>E, a selective nicotinic receptor antagonist.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The ecto\u20105\u2032\u2010nucleotidase inhibitor AOPCP produces a 72% inhibition in the release of adenosine from CB evoked by nicotine.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Taken together, these data indicate that ACh induced the production of adenosine, mainly from extracellular ATP catabolism at the CB through a mechanism that involves the activation of nicotinic receptors with <jats:italic>\u03b1<\/jats:italic>4 and <jats:italic>\u03b2<\/jats:italic>2 receptor subunits.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2006) <jats:bold>147<\/jats:bold>, 783\u2013789. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0706676\">10.1038\/sj.bjp.0706676<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0706676","type":"journal-article","created":{"date-parts":[[2006,1,30]],"date-time":"2006-01-30T12:05:03Z","timestamp":1138622703000},"page":"783-789","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Activation of nicotinic ACh receptors with <i>\u03b1<\/i>4 subunits induces adenosine release at the rat carotid body"],"prefix":"10.1111","volume":"147","author":[{"given":"S\u00edlvia V","family":"Conde","sequence":"first","affiliation":[]},{"given":"Em\u00edlia C","family":"Monteiro","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"issue":"1","key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1038\/sj.bjp.0705586","volume":"141","author":"ALEXANDER S.P.","year":"2004","journal-title":"Br. 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