{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:25:46Z","timestamp":1773797146174,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":334,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:sec><jats:title>Background and purpose:<\/jats:title><jats:p>This study was conducted to investigate the effects of \u03b1\u2010lipoic acid (\u03b1\u2010LA) on endothelial function in diabetic and high\u2010fat fed animal models and elucidate the potential mechanism underlying the benefits of \u03b1\u2010LA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental approach:<\/jats:title><jats:p>Plasma metabolites reflecting glucose and lipid metabolism, endothelial function, urinary albumin excretion (UAE), plasma and aortic malondialdehyde (MDA) and urinary 8\u2010hydroxydeoxyguanosine (8\u2010OHdG) were assessed in non\u2010diabetic controls (Wistar rats), untreated Goto\u2010Kakizaki (GK) diabetic and high\u2010fat fed GK rats (fed with atherogenic diet only, treated with \u03b1\u2010LA and treated with vehicle, for 3 months). Vascular eNOS, nitrotyrosine, carbonyl groups and superoxide anion were also assessed in the different groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key results:<\/jats:title><jats:p>\u03b1\u2010LA and soybean oil significantly reduced both total and non\u2010HDL serum cholesterol and triglycerides induced by atherogenic diet. MDA, carbonyl groups, vascular superoxide and 8\u2010OHdG levels were higher in GK and high\u2010fat fed GK groups and fully reversed with \u03b1\u2010LA treatment. High\u2010fat fed GK diabetic rats showed significantly reduced endothelial function and increased UAE, effects ameliorated with \u03b1\u2010LA. This endothelial dysfunction was associated with decreased NO production, decreased expression of eNOS and increased vascular superoxide production and nitrotyrosine expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and implications:<\/jats:title><jats:p>\u03b1\u2010LA restores endothelial function and significantly improves systemic and local oxidative stress in high\u2010fat fed GK diabetic rats. Improved endothelial function due to \u03b1\u2010LA was at least partially attributed to recoupling of eNOS and increased NO bioavailability and represents a pharmacological approach to prevent major complications associated with type 2 diabetes.<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2008) <jats:bold>153<\/jats:bold>, 894\u2013906; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0707474\">10.1038\/sj.bjp.0707474<\/jats:ext-link>; published online 1 October 2007<\/jats:p><\/jats:sec>","DOI":"10.1038\/sj.bjp.0707474","type":"journal-article","created":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T09:52:19Z","timestamp":1191232339000},"page":"894-906","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Effects of \u03b1\u2010lipoic acid on endothelial function in aged diabetic and high\u2010fat fed 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