{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:10:22Z","timestamp":1762078222269},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2001,4]]},"DOI":"10.1038\/sj.cdd.4400869","type":"journal-article","created":{"date-parts":[[2002,9,17]],"date-time":"2002-09-17T17:36:10Z","timestamp":1032284170000},"page":"319-323","source":"Crossref","is-referenced-by-count":7,"title":["Search for Drosophila caspases bears fruit: STRICA enters the fray"],"prefix":"10.1038","volume":"8","author":[{"given":"C","family":"Adrain","sequence":"first","affiliation":[]},{"given":"S J","family":"Martin","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2001,5,1]]},"reference":[{"key":"BF4400869_CR1","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1038\/sj.cdd.4400601","volume":"6","author":"EA Slee","year":"1999","unstructured":"Slee EA, Adrain C, Martin SJ . 1999 Serial killers: ordering caspase activation events in apoptosis Cell Death Differ. 6: 1067\u20131074","journal-title":"Cell Death Differ."},{"key":"BF4400869_CR2","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1038\/sj.cdd.4400756","volume":"7","author":"S Kumar","year":"2000","unstructured":"Kumar S, Doumanis J . 2000 The fly caspases Cell Death Differ. 7: 1039\u20131044","journal-title":"Cell Death Differ."},{"key":"BF4400869_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/bj3260001","volume":"326","author":"GM Cohen","year":"1997","unstructured":"Cohen GM . 1997 Caspases: the executioners of apoptosis Biochem J. 326: 1\u201316","journal-title":"Biochem J."},{"key":"BF4400869_CR4","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1038\/sj.cdd.4400593","volume":"6","author":"TS Zheng","year":"1999","unstructured":"Zheng TS, Hunot S, Kuida K, Flavell RA . 1999 Caspase knockouts: matters of life and death Cell Death Differ. 6: 1043\u20131053","journal-title":"Cell Death Differ."},{"key":"BF4400869_CR5","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1006\/excr.2000.4841","volume":"256","author":"TS Zheng","year":"2000","unstructured":"Zheng TS, Flavell RA . 2000 Divinations and surprises: genetic analysis of caspase function in mice Exp. Cell. Res. 256: 67\u201373","journal-title":"Exp. Cell. Res."},{"key":"BF4400869_CR6","doi-asserted-by":"publisher","first-page":"F69","DOI":"10.1083\/jcb.150.2.F69","volume":"150","author":"SY Vernooy","year":"2000","unstructured":"Vernooy SY, Copeland J, Ghaboosi N, Griffin EE, Yoo SJ, Hay BA . 2000 Cell death regulation in Drosophila: conservation of mechanism and unique insights J. Cell. Biol. 150: F69\u2013F76","journal-title":"J. Cell. Biol."},{"key":"BF4400869_CR7","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1038\/sj.cdd.4400765","volume":"7","author":"BA Hay","year":"2000","unstructured":"Hay BA . 2000 Understanding IAP function and regulation: a view from Drosophila Cell Death Differ. 7: 1045\u20131056","journal-title":"Cell Death Differ."},{"key":"BF4400869_CR8","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/sj.cdd.4400864","volume":"8","author":"J Doumanis","year":"2001","unstructured":"Doumanis J, Quinn L, Richardson H, Kumar S . 2001 STRICA, a novel Drosophila caspase with an unusual serine\/threonine-rich prodomain, interacts with DIAP1 and DIAP2 Cell Death Differ. 8: 387\u2013394","journal-title":"Cell Death Differ."},{"key":"BF4400869_CR9","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1126\/science.275.5299.536","volume":"275","author":"Z Song","year":"1997","unstructured":"Song Z, McCall K, Steller H . 1997 DCP-1, a Drosophila cell death protease essential for development Science 275: 536\u2013540","journal-title":"Science"},{"key":"BF4400869_CR10","doi-asserted-by":"publisher","first-page":"6192","DOI":"10.1093\/emboj\/16.20.6192","volume":"16","author":"AG Fraser","year":"1997","unstructured":"Fraser AG, McCarthy NJ, Evan GI . 1997 drICE is an essential caspase required for apoptotic activity in Drosophila cells EMBO J. 16: 6192\u20136199","journal-title":"EMBO J."},{"key":"BF4400869_CR11","doi-asserted-by":"publisher","first-page":"30778","DOI":"10.1074\/jbc.274.43.30778","volume":"274","author":"L Dorstyn","year":"1999","unstructured":"Dorstyn L, Read SH, Quinn LM, Richardson H, Kumar S . 1999 DECAY, a novel Drosophila caspase related to mammalian caspase-3 and caspase-7 J. Biol. Chem. 274: 30778\u201330783","journal-title":"J. Biol. Chem."},{"key":"BF4400869_CR12","doi-asserted-by":"publisher","first-page":"2907","DOI":"10.1128\/MCB.20.8.2907-2914.2000","volume":"20","author":"Z Song","year":"2000","unstructured":"Song Z, Guan B, Bergman A, Nicholson DW, Thornberry NA, Peterson EP, Steller H . 2000 Biochemical and genetic interactions between Drosophila caspases and the proapoptotic genes rpr, hid, and grim Mol. Cell. Biol. 20: 2907\u20132914","journal-title":"Mol. Cell. Biol."},{"key":"BF4400869_CR13","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.1093\/emboj\/16.10.2805","volume":"16","author":"AG Fraser","year":"1997","unstructured":"Fraser AG, Evan GI . 1997 Identification of a Drosophila melanogaster ICE\/CED-3-related protease, drICE EMBO J. 16: 2805\u20132813","journal-title":"EMBO J."},{"key":"BF4400869_CR14","doi-asserted-by":"publisher","first-page":"6192","DOI":"10.1093\/emboj\/16.20.6192","volume":"16","author":"AG Fraser","year":"1997","unstructured":"Fraser AG, McCarthy NJ, Evan GI . 1997 drICE is an essential caspase required for apoptotic activity in Drosophila cells EMBO J. 16: 6192\u20136199","journal-title":"EMBO J."},{"key":"BF4400869_CR15","doi-asserted-by":"publisher","first-page":"21402","DOI":"10.1074\/jbc.M909611199","volume":"275","author":"N Mukae","year":"2000","unstructured":"Mukae N, Yokoyama H, Yokokura T, Sakoyama Y, Sakahira H, Nagata S . 2000 Identification and developmental expression of inhibitor of caspase-activated DNase (ICAD) in Drosophila melanogaster J. Biol. Chem. 275: 21402\u201321408","journal-title":"J. Biol. Chem."},{"key":"BF4400869_CR16","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1083\/jcb.144.2.281","volume":"144","author":"EA Slee","year":"1999","unstructured":"Slee EA, Harte MT, Kluck RM, Wolf BB, Casiano CA, Newmeyer DD, Wang HG, Reed JC, Nicholson DW, Alnemri ES, Green DR, Martin SJ . 1999 Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner J. Cell. Biol. 144: 281\u2013292","journal-title":"J. Cell. Biol."},{"key":"BF4400869_CR17","doi-asserted-by":"crossref","first-page":"27084","DOI":"10.1016\/S0021-9258(19)61483-3","volume":"275","author":"CJ Hawkins","year":"2000","unstructured":"Hawkins CJ, Yoo SJ, Peterson EP, Wang SL, Vernooy SY, Hay BA . 2000 The Drosophila caspase DRONC cleaves following glutamate or aspartate and is regulated by DIAP1, HID, and GRIM J. Biol. Chem. 275: 27084\u201327093","journal-title":"J. Biol. Chem."},{"key":"BF4400869_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0968-0004(98)01332-2","volume":"24","author":"S Kumar","year":"1999","unstructured":"Kumar S, Colussi PA . 1999 Prodomains, adaptors, oligomerization: the pursuit of caspase activation in apoptosis Trends Biochem. Sci. 24: 1\u20134","journal-title":"Trends Biochem. Sci."},{"key":"BF4400869_CR19","doi-asserted-by":"publisher","first-page":"27099","DOI":"10.1074\/jbc.271.43.27099","volume":"271","author":"SM Srinivasula","year":"1996","unstructured":"Srinivasula SM, Fernandes-Alnemri T, Zangrilli J, Robertson N, Armstrong RC, Wang L, Trapani JA, KJ, Litwack G, Alnemri ES . 1996 The Ced-3\/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32 J. Biol. Chem. 271: 27099\u201327106","journal-title":"J. Biol. Chem."},{"key":"BF4400869_CR20","doi-asserted-by":"publisher","first-page":"16720","DOI":"10.1074\/jbc.271.28.16720","volume":"271","author":"H Duan","year":"1996","unstructured":"Duan H, Orth K, Chinnaiyan AM, Poirier GG, Froelich CJ, He WW, Dixit VM . 1996 ICE -LAP6, a novel member of the ICE\/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B J. Biol. Chem. 271: 16720\u201316724","journal-title":"J. Biol. Chem."},{"key":"BF4400869_CR21","doi-asserted-by":"publisher","first-page":"4307","DOI":"10.1073\/pnas.96.8.4307","volume":"96","author":"L Dorstyn","year":"1999","unstructured":"Dorstyn L, Colussi PA, Quinn LM, Richardson H, Kumar S . 1999 DRONC, an ecdysone-inducible Drosophila caspase Proc. Natl. Acad. Sci. USA 96: 4307\u20134312","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF4400869_CR22","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/S0092-8674(00)80434-1","volume":"91","author":"P Li","year":"1997","unstructured":"Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X . 1997 Cytochrome c and dATP-dependent formation of Apaf-1\/caspase-9 complex initiates an apoptotic protease cascade Cell. 91: 479\u2013489","journal-title":"Cell."},{"key":"BF4400869_CR23","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/12984","volume":"1","author":"A Rodriguez","year":"1999","unstructured":"Rodriguez A, Oliver H, Zou H, Chen P, Wang X, Abrams JM . 1999 DARK is a Drosophila homologue of Apaf-1\/CED-4 and functions in an evolutionarily conserved death pathway Nat. Cell. Biol. 1: 272\u2013279","journal-title":"Nat. Cell. Biol."},{"key":"BF4400869_CR24","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/S1097-2765(00)80386-X","volume":"4","author":"H Kanuka","year":"1999","unstructured":"Kanuka H, Sawamoto K, Inohara N, Matsuno K, Okano H, Miura M . 1999 Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1\/CED-4-related caspase activator Mol. Cell. 4: 757\u2013769","journal-title":"Mol. Cell."},{"key":"BF4400869_CR25","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/S1097-2765(00)80385-8","volume":"4","author":"L Zhou","year":"1999","unstructured":"Zhou L, Song Z, Tittel J, Steller H . 1999 HAC-1, a Drosophila homolog of APAF-1 and CED-4 functions in developmental and radiation-induced apoptosis Mol. Cell. 4: 745\u2013755","journal-title":"Mol. Cell."},{"key":"BF4400869_CR26","doi-asserted-by":"publisher","first-page":"40416","DOI":"10.1074\/jbc.M002935200","volume":"275","author":"LM Quinn","year":"2000","unstructured":"Quinn LM, Dorstyn L, Mills K, Colussi PA, Chen P, Coombe M, Abrams J, Kumar S, Richardson H . 2000 An essential role for the caspase dronc in developmentally programmed cell death in Drosophila J. Biol. Chem. 275: 40416\u201340424","journal-title":"J. Biol. Chem."},{"key":"BF4400869_CR27","doi-asserted-by":"publisher","first-page":"6067","DOI":"10.1074\/jbc.275.9.6067","volume":"275","author":"K Cain","year":"2000","unstructured":"Cain K, Bratton SB, Langlais C, Walker G, Brown DG, Sun XM, Cohen GM . 2000 Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes J. Biol. Chem. 275: 6067\u20136070","journal-title":"J. Biol. Chem."},{"key":"BF4400869_CR28","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1083\/jcb.144.4.701","volume":"144","author":"J Varkey","year":"1999","unstructured":"Varkey J, Chen P, Jemmerson R, Abrams JM . 1999 Altered cytochrome c display precedes apoptotic cell death in Drosophila J. Cell. Biol. 144: 701\u2013710","journal-title":"J. Cell. Biol."},{"key":"BF4400869_CR29","doi-asserted-by":"publisher","first-page":"30761","DOI":"10.1074\/jbc.C000341200","volume":"275","author":"S Hu","year":"2000","unstructured":"Hu S, Yang X . 2000 dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD J. Biol. Chem. 275: 30761\u201330764","journal-title":"J. Biol. Chem."},{"key":"BF4400869_CR30","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/S0092-8674(00)81266-0","volume":"85","author":"M Muzio","year":"1996","unstructured":"Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Mann M, Krammer PH, Peter ME, Dixit VM . 1996 FLICE, a novel FADD-homologous ICE\/CED-3-like protease, is recruited to the CD95 (Fas\/APO-1) death\u2013inducing signaling complex Cell. 85: 817\u2013827","journal-title":"Cell."},{"key":"BF4400869_CR31","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1006\/dbio.1998.9000","volume":"201","author":"P Chen","year":"1998","unstructured":"Chen P, Rodriguez A, Erskine R, Thach T, Abrams JM . 1998 DREDD, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila Dev. Biol. 201: 202\u2013216","journal-title":"Dev. Biol."},{"key":"BF4400869_CR32","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1126\/science.281.5381.1305","volume":"281","author":"A Ashkenazi","year":"1998","unstructured":"Ashkenazi A, Dixit VM . 1998 Death receptors: signaling and modulation Science. 281: 1305\u20131308","journal-title":"Science."},{"key":"BF4400869_CR33","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1093\/embo-reports\/kvd072","volume":"1","author":"S St\u00f6ven","year":"2000","unstructured":"St\u00f6ven S, Ando A, Kadalayil L, Engstr\u00f6m Y, Hultmark D . 2000 Activation of the Drosophila NF-kB factor Relish by rapid endoproteolytic cleavage EMBO reports 1: 347\u2013352","journal-title":"EMBO reports"},{"key":"BF4400869_CR34","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1093\/embo-reports\/kvd073","volume":"1","author":"F Leulier","year":"2000","unstructured":"Leulier F, Rodriguez A, Khush, RS, Abrams JM, Lemaitre B . 2000 The Drosophila caspase DREDD is required to reisit Gram-negative bacterial infection EMBO reports 1: 353\u2013358","journal-title":"EMBO reports"},{"key":"BF4400869_CR35","doi-asserted-by":"publisher","first-page":"10838","DOI":"10.1074\/jbc.275.15.10838","volume":"275","author":"WH Hu","year":"2000","unstructured":"Hu WH, Johnson H, Shu HB . 2000 Activation of NF-kappaB by FADD, Casper, and caspase-8 J. Biol. Chem. 275: 10838\u201310844","journal-title":"J. Biol. Chem."},{"key":"BF4400869_CR36","doi-asserted-by":"crossref","first-page":"18062","DOI":"10.1016\/S0021-9258(17)46811-6","volume":"268","author":"DK Miller","year":"1993","unstructured":"Miller DK, Ayala JM, Egger LA, Raju SM, Yamin TT, Ding GJ, Gaffney EP, Howard AD, Palyha OC, Rolando AM . 1993 Purification and characterization of active human interleukin-1 beta-converting enzyme from THP.1 monocytic cells J. Biol. Chem. 268: 18062\u201318069","journal-title":"J. Biol. Chem."},{"key":"BF4400869_CR37","doi-asserted-by":"publisher","first-page":"6135","DOI":"10.1093\/emboj\/17.21.6135","volume":"17","author":"K Thress","year":"1998","unstructured":"Thress K, Henzel W, Shillinglaw W, Kornbluth S . 1998 Scythe: a novel reaper-binding apoptotic regulator EMBO J. 17: 6135\u20136143","journal-title":"EMBO J."},{"key":"BF4400869_CR38","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1016\/0092-8674(95)90150-7","volume":"83","author":"BA Hay","year":"1995","unstructured":"Hay BA, Wassarman DA, Rubin GM . 1995 Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death Cell. 83: 1253\u20131262","journal-title":"Cell."}],"container-title":["Cell Death &amp; Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/4400869.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/4400869","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/4400869.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:17:31Z","timestamp":1684369051000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/4400869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["BF4400869"],"URL":"https:\/\/doi.org\/10.1038\/sj.cdd.4400869","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4]]}}}