{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T06:27:08Z","timestamp":1770359228693,"version":"3.49.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2005,11,11]],"date-time":"2005-11-11T00:00:00Z","timestamp":1131667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2006,4]]},"DOI":"10.1038\/sj.cdd.4401785","type":"journal-article","created":{"date-parts":[[2005,11,11]],"date-time":"2005-11-11T09:04:55Z","timestamp":1131699895000},"page":"652-660","source":"Crossref","is-referenced-by-count":20,"title":["Excitotoxicity mediated by Ca2+-permeable GluR4-containing AMPA receptors involves the AP-1 transcription factor"],"prefix":"10.1038","volume":"13","author":[{"given":"A E","family":"Santos","sequence":"first","affiliation":[]},{"given":"C B","family":"Duarte","sequence":"additional","affiliation":[]},{"given":"M","family":"Iizuka","sequence":"additional","affiliation":[]},{"given":"E L","family":"Barsoumian","sequence":"additional","affiliation":[]},{"given":"J","family":"Ham","sequence":"additional","affiliation":[]},{"given":"M C","family":"Lopes","sequence":"additional","affiliation":[]},{"given":"A P","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"A L","family":"Carvalho","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2005,11,11]]},"reference":[{"key":"BF4401785_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s001090000077","volume":"78","author":"R Sattler","year":"2000","unstructured":"Sattler R and Tymianski M (2000) Molecular mechanisms of calcium-dependent excitotoxicity. J. Mol. Med. 78: 3\u201313","journal-title":"J. Mol. Med."},{"key":"BF4401785_CR2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0031-6997(24)01394-2","volume":"51","author":"R Dingledine","year":"1999","unstructured":"Dingledine R, Borges K, Bowie D and Traynelis SF (1999) The glutamate receptor ion channels. Pharmacol. Rev. 51: 7\u201361","journal-title":"Pharmacol. Rev."},{"key":"BF4401785_CR3","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/0014-2999(96)00044-1","volume":"302","author":"IL Ferreira","year":"1996","unstructured":"Ferreira IL, Duarte CB and Carvalho AP (1996) Ca2+ influx through glutamate receptor-associated channels in retina cells correlates with neuronal cell death. Eur. J. Pharmacol. 302: 153\u2013162","journal-title":"Eur. J. Pharmacol."},{"key":"BF4401785_CR4","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1002\/jnr.10036","volume":"66","author":"AE Santos","year":"2001","unstructured":"Santos AE, Carvalho AL, Lopes MC and Carvalho AP (2001) Differential postreceptor signalling events triggered by excitotoxic stimulation of different ionotropic glutamate receptors in retinal neurons. J. Neurosci. Res. 66: 643\u2013655","journal-title":"J. Neurosci. Res."},{"key":"BF4401785_CR5","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/nn835","volume":"5","author":"GE Hardingham","year":"2002","unstructured":"Hardingham GE, Fukunaga Y and Bading H (2002) Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat. Neurosci. 5: 405\u2013414","journal-title":"Nat. Neurosci."},{"key":"BF4401785_CR6","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nrn725","volume":"3","author":"DR Madden","year":"2002","unstructured":"Madden DR (2002) The structure and function of glutamate receptor ion channels. Nat. Rev. Neurosci. 3: 91\u2013101","journal-title":"Nat. Rev. Neurosci."},{"key":"BF4401785_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1046\/j.1471-4159.1996.66010001.x","volume":"66","author":"PH Seeburg","year":"1996","unstructured":"Seeburg PH (1996) The role of RNA editing in controlling glutamate receptor channel properties. J. Neurochem. 66: 1\u20135","journal-title":"J. Neurochem."},{"key":"BF4401785_CR8","doi-asserted-by":"publisher","first-page":"6179","DOI":"10.1523\/JNEUROSCI.17-16-06179.1997","volume":"17","author":"JA Gorter","year":"1997","unstructured":"Gorter JA, Petrozzino JJ, Aronica EM, Rosenbaum DM, Opitz T, Bennett MV, Connor JA and Zukin RS (1997) Global ischemia induces downregulation of GluR2 mRNA and increases AMPA receptor-mediated Ca2+ influx in hippocampal CA1 neurons of gerbil. J. Neurosci. 17: 6179\u20136188","journal-title":"J. Neurosci."},{"key":"BF4401785_CR9","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.neuron.2004.06.017","volume":"43","author":"S Liu","year":"2004","unstructured":"Liu S, Lau L, Wei JS, Zhu DY, Zou S, Sun HS, Fu YP, Liu F and Lu YM (2004) Expression of Ca2+-permeable AMPA receptor channels primes cell death in transient forebrain ischemia. Neuron 43: 43\u201355","journal-title":"Neuron"},{"key":"BF4401785_CR10","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0022-510X(00)00414-7","volume":"180","author":"L Van Den Bosch","year":"2000","unstructured":"Van Den Bosch L, Vandenberghe W, Klaassen H, Van Houtte E and Robberecht W (2000) Ca2+-permeable AMPA receptors and selective vulnerability of motor neurons. J. Neurol. Sci. 180: 29\u201334","journal-title":"J. Neurol. Sci."},{"key":"BF4401785_CR11","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1038\/427801a","volume":"427","author":"Y Kawahara","year":"2004","unstructured":"Kawahara Y, Ito K, Sun H, Aizawa H, Kanazawa I and Kwak S (2004) RNA editing and death of motor neurons. Nature 427: 801","journal-title":"Nature"},{"key":"BF4401785_CR12","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1097\/00001756-199407000-00017","volume":"5","author":"HZ Yin","year":"1994","unstructured":"Yin HZ, Lindsay AD and Weiss JH (1994) Kainate injury to cultured basal forebrain cholinergic neurons is Ca2+ dependent. Neuroreport 5: 1477\u20131480","journal-title":"Neuroreport"},{"key":"BF4401785_CR13","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1111\/j.1460-9568.1995.tb01090.x","volume":"7","author":"KJ Page","year":"1995","unstructured":"Page KJ and Everitt BJ (1995) The distribution of neurons coexpressing immunoreactivity to AMPA-sensitive glutamate receptor subtypes (GluR1-4) and nerve growth factor receptor in the rat basal forebrain. Eur. J. Neurosci. 7: 1022\u20131033","journal-title":"Eur. J. Neurosci."},{"key":"BF4401785_CR14","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1046\/j.0953-816x.2001.01648.x","volume":"14","author":"W Vandenberghe","year":"2001","unstructured":"Vandenberghe W, Bindokas VP, Miller RJ, Robberecht W and Brorson JR (2001) Subcellular localization of calcium-permeable AMPA receptors in spinal motoneurons. Eur. J. Neurosci. 14: 305\u2013314","journal-title":"Eur. J. Neurosci."},{"key":"BF4401785_CR15","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1046\/j.0953-816x.2001.01881.x","volume":"15","author":"AL Carvalho","year":"2002","unstructured":"Carvalho AL, Correia S, Faro CJ, Duarte CB, Carvalho AP and Pires EM (2002) Phosphorylation of GluR4 AMPA-type glutamate receptor subunit by protein kinase C in cultured retina amacrine neurons. Eur. J. Neurosci. 15: 465\u2013474","journal-title":"Eur. J. Neurosci."},{"key":"BF4401785_CR16","doi-asserted-by":"publisher","first-page":"E131","DOI":"10.1038\/ncb0502-e131","volume":"4","author":"E Shaulian","year":"2002","unstructured":"Shaulian E and Karin M (2002) AP-1 as a regulator of cell life and death. Nat. Cell Biol. 4: E131\u2013E136","journal-title":"Nat. Cell Biol."},{"key":"BF4401785_CR17","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/6854","volume":"21","author":"A Behrens","year":"1999","unstructured":"Behrens A, Sibilia M and Wagner EF (1999) Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat. Genet. 21: 326\u2013329","journal-title":"Nat. Genet."},{"key":"BF4401785_CR18","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1038\/39899","volume":"389","author":"DD Yang","year":"1997","unstructured":"Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic P and Flavell RA (1997) Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 389: 865\u2013870","journal-title":"Nature"},{"key":"BF4401785_CR19","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/nm911","volume":"9","author":"T Borsello","year":"2003","unstructured":"Borsello T, Clarke PGH, Hirt L, Vercelli A, Repici M, Schorderet DF, Bogouslavsky J and Bonny C (2003) A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Nat. Med. 9: 1180\u20131186","journal-title":"Nat. Med."},{"key":"BF4401785_CR20","doi-asserted-by":"publisher","first-page":"15184","DOI":"10.1073\/pnas.2336254100","volume":"100","author":"CY Kuan","year":"2003","unstructured":"Kuan CY, Whitmarsh AJ, Yang DD, Liao G, Schloemer AJ, Dong C, Bao J, Banasiak KJ, Haddad GG, Flavell RA, Davis RJ and Rakic P (2003) A critical role of neural-specific JNK3 for ischemic apoptosis. Proc. Natl. Acad. Sci. USA 100: 15184\u201315189","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF4401785_CR21","doi-asserted-by":"publisher","first-page":"3900","DOI":"10.1046\/j.1460-9568.2000.00270.x","volume":"12","author":"M Iizuka","year":"2000","unstructured":"Iizuka M, Nishimura S, Wakamori M, Akiba I, Imoto K and Barsoumian EL (2000) The lethal expression of the GluR2flip\/GluR4flip AMPA receptor in HEK293 cells. Eur. J. Neurosci. 12: 3900\u20133908","journal-title":"Eur. J. Neurosci."},{"key":"BF4401785_CR22","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1523\/JNEUROSCI.17-01-00058.1997","volume":"17","author":"GT Swanson","year":"1997","unstructured":"Swanson GT, Kamboj SK and Cull-Candy SG (1997) Single-channel properties of recombinant AMPA receptors depend on RNA editing, splice variation, and subunit composition. J. Neurosci. 17: 58\u201369","journal-title":"J. Neurosci."},{"key":"BF4401785_CR23","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1002\/syn.10098","volume":"45","author":"M Tomiyama","year":"2002","unstructured":"Tomiyama M, Rodriguez-Puertas R, Cortes R, Pazos A, Palacios JM and Mengod G (2002) Flip and flop splice variants of AMPA receptor subunits in the spinal cord of amyotrophic lateral sclerosis. Synapse 45: 245\u2013249","journal-title":"Synapse"},{"key":"BF4401785_CR24","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1126\/science.7973663","volume":"266","author":"J Mosbacher","year":"1994","unstructured":"Mosbacher J, Schoepfer R, Monyer H, Burnashev N, Seeburg PH and Ruppersberg JP (1994) A molecular determinant for submillisecond desensitization in glutamate receptors. Science 266: 1059\u20131062","journal-title":"Science"},{"key":"BF4401785_CR25","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/0896-6273(95)90186-8","volume":"15","author":"M Ankarcrona","year":"1995","unstructured":"Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA and Nicotera P (1995) Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15: 961\u2013973","journal-title":"Neuron"},{"key":"BF4401785_CR26","doi-asserted-by":"publisher","first-page":"2973","DOI":"10.1523\/JNEUROSCI.12-08-02973.1992","volume":"12","author":"LS Lerea","year":"1992","unstructured":"Lerea LS, Butler LS and McNamara JO (1992) NMDA and non-NMDA receptor-mediated increase of c-fos mRNA in dentate gyrus neurons involves calcium influx via different routes. J. Neurosci. 12: 2973\u20132981","journal-title":"J. Neurosci."},{"key":"BF4401785_CR27","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1002\/(SICI)1097-4547(19980615)52:6<641::AID-JNR3>3.0.CO;2-8","volume":"52","author":"R Griffiths","year":"1998","unstructured":"Griffiths R, Ritchie L, Lidwell K, Grieve A, Malcolm CS, Scott M and Meredith C (1998) Calcium influx via L-type voltage-gated channels mediates the delayed, elevated increases in steady-state c-fos mRNA levels in cerebellar granule cells exposed to excitotoxic levels of glutamate. J. Neurosci. Res. 52: 641\u2013652","journal-title":"J. Neurosci. Res."},{"key":"BF4401785_CR28","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/0896-6273(95)90331-3","volume":"14","author":"J Ham","year":"1995","unstructured":"Ham J, Babij C, Whitfield J, Pfarr CM, Lallemand D, Yaniv M and Rubin LL (1995) A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 14: 927\u2013939","journal-title":"Neuron"},{"key":"BF4401785_CR29","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/0306-4522(94)90494-4","volume":"60","author":"JH Weiss","year":"1994","unstructured":"Weiss JH, Yin HZ and Choi DW (1994) Basal forebrain cholinergic neurons are selectively vulnerable to AMPA\/kainate receptor-mediated neurotoxicity. Neuroscience 60: 659\u2013664","journal-title":"Neuroscience"},{"key":"BF4401785_CR30","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1017\/S095252389916108X","volume":"16","author":"Q Chen","year":"1999","unstructured":"Chen Q, Olney JW, Price MT and Romano C (1999) Biochemical and morphological analysis of non-NMDA receptor mediated excitotoxicity in chick embryo retina. Vis. Neurosci. 16: 131\u2013139","journal-title":"Vis. Neurosci."},{"key":"BF4401785_CR31","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1046\/j.1471-4159.1998.70052112.x","volume":"70","author":"AL Carvalho","year":"1998","unstructured":"Carvalho AL, Duarte CB, Faro CJ, Carvalho AP and Pires EV (1998) Calcium influx through AMPA receptors and through calcium channels is regulated by protein kinase C in cultured retina amacrine-like cells. J. Neurochem. 70: 2112\u20132119","journal-title":"J. Neurochem."},{"key":"BF4401785_CR32","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1097\/00001756-199705260-00036","volume":"8","author":"AL Utz","year":"1997","unstructured":"Utz AL and Verdoorn TA (1997) Recombinant AMPA receptors with low Ca2+ permeability increase intracellular Ca2+ in HEK 293 cells. Neuroreport 8: 1975\u20131980","journal-title":"Neuroreport"},{"key":"BF4401785_CR33","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1111\/j.1460-9568.1994.tb00546.x","volume":"6","author":"B Kaminska","year":"1994","unstructured":"Kaminska B, Filipkowski RK, Zurkowska G, Lason W, Przewlocki R and Kaczmarek L (1994) Dynamic changes in the composition of the AP-1 transcription factor DNA-binding activity in rat brain following kainate-induced seizures and cell death. Eur. J. Neurosci. 6: 1558\u20131566","journal-title":"Eur. J. Neurosci."},{"key":"BF4401785_CR34","doi-asserted-by":"publisher","first-page":"3455","DOI":"10.1523\/JNEUROSCI.17-10-03455.1997","volume":"17","author":"MA Schwarzschild","year":"1997","unstructured":"Schwarzschild MA, Cole RL and Hyman SE (1997) Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neurons. J. Neurosci. 17: 3455\u20133466","journal-title":"J. Neurosci."},{"key":"BF4401785_CR35","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0006-8993(97)00049-8","volume":"754","author":"YN Hou","year":"1997","unstructured":"Hou YN, Cebers G, Terenius L and Liljequist S (1997) Characterization of NMDA- and AMPA-induced enhancement of AP-1 DNA binding activity in rat cerebellar granule cells. Brain Res. 754: 79\u201387","journal-title":"Brain Res."},{"key":"BF4401785_CR36","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1046\/j.1471-4159.1995.65031027.x","volume":"65","author":"F Finiels","year":"1995","unstructured":"Finiels F, Robert JJ, Samolyk ML, Privat A, Mallet J and Revah F (1995) Induction of neuronal apoptosis by excitotoxins associated with long-lasting increase of 12-O-tetradecanoylphorbol 13-acetate-responsive element-binding activity. J. Neurochem. 65: 1027\u20131034","journal-title":"J. Neurochem."},{"key":"BF4401785_CR37","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S0896-6273(01)00239-2","volume":"29","author":"J Whitfield","year":"2001","unstructured":"Whitfield J, Neame SJ, Paquet L, Bernard O and Ham J (2001) Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release. Neuron 29: 629\u2013643","journal-title":"Neuron"},{"key":"BF4401785_CR38","doi-asserted-by":"publisher","first-page":"11382","DOI":"10.1074\/jbc.M100190200","volume":"276","author":"A Savinainen","year":"2001","unstructured":"Savinainen A, Garcia EP, Dorow D, Marshall J and Liu YF (2001) Kainate receptor activation induces mixed lineage kinase-mediated cellular signalling cascades via post-synaptic density protein 95. J. Biol. Chem. 276: 11382\u201311386","journal-title":"J. Biol. Chem."},{"key":"BF4401785_CR39","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1126\/science.1072873","volume":"298","author":"M Aarts","year":"2002","unstructured":"Aarts M, Liu Y, Liu L, Besshoh S, Arundine M, Gurd JW, Wang YT, Salter MW and Tymianski M (2002) Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions. Science 298: 846\u2013850","journal-title":"Science"},{"key":"BF4401785_CR40","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1385\/0-89603-451-8:237","volume-title":"Neuromethods: Apoptosis Techniques and Protocols","author":"EAM Bonfoco","year":"1997","unstructured":"Bonfoco EAM, Krainc D, Nicotera P and Lipton S (1997) Techniques for distinguishing apoptosis from necrosis in cerebrocortical and cerebellar neurons. In Neuromethods: Apoptosis Techniques and Protocols, Poirier J ed (New Jersey: Humana Press) pp. 237\u2013253"}],"container-title":["Cell Death &amp; Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/4401785.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/4401785","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/4401785.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T12:28:11Z","timestamp":1736080091000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/4401785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,11]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["BF4401785"],"URL":"https:\/\/doi.org\/10.1038\/sj.cdd.4401785","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,11]]}}}