{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:25:02Z","timestamp":1762100702268},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2007,8,17]],"date-time":"2007-08-17T00:00:00Z","timestamp":1187308800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1038\/sj.cdd.4402211","type":"journal-article","created":{"date-parts":[[2007,8,17]],"date-time":"2007-08-17T09:07:52Z","timestamp":1187341672000},"page":"1958-1967","source":"Crossref","is-referenced-by-count":41,"title":["Crosstalk among Bcl-2 family members in B-CLL: seliciclib acts via the Mcl-1\/Noxa axis and gradual exhaustion of Bcl-2 protection"],"prefix":"10.1038","volume":"14","author":[{"given":"D Y H","family":"Hallaert","sequence":"first","affiliation":[]},{"given":"R","family":"Spijker","sequence":"additional","affiliation":[]},{"given":"M","family":"Jak","sequence":"additional","affiliation":[]},{"given":"I A M","family":"Derks","sequence":"additional","affiliation":[]},{"given":"N L","family":"Alves","sequence":"additional","affiliation":[]},{"given":"F M","family":"Wensveen","sequence":"additional","affiliation":[]},{"given":"J P","family":"de Boer","sequence":"additional","affiliation":[]},{"given":"D","family":"de Jong","sequence":"additional","affiliation":[]},{"given":"S R","family":"Green","sequence":"additional","affiliation":[]},{"given":"M H J","family":"van Oers","sequence":"additional","affiliation":[]},{"given":"E","family":"Eldering","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2007,8,17]]},"reference":[{"issue":"1","key":"BF4402211_CR1","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1182\/asheducation-2004.1.163","volume":"2004","author":"J. C. Byrd","year":"2004","unstructured":"Byrd JC, Stilgenbauer S, Flinn IW . Chronic lymphocytic leukemia. Hematology (Am Soc Hematol Educ Program) 2004: 163\u2013183.","journal-title":"Hematology"},{"key":"BF4402211_CR2","first-page":"456","volume":"10","author":"LE Robertson","year":"1996","unstructured":"Robertson LE, Plunkett W, McConnell K, Keating MJ, McDonnell TJ . Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome. Leukemia 1996; 10: 456\u2013459.","journal-title":"Leukemia"},{"key":"BF4402211_CR3","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1182\/blood.V91.9.3379","volume":"91","author":"S Kitada","year":"1998","unstructured":"Kitada S, Andersen J, Akar S, Zapata JM, Takayama S, Krajewski S et al. Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with in vitro and in vivo chemoresponses. Blood 1998; 91: 3379\u20133389.","journal-title":"Blood"},{"key":"BF4402211_CR4","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/ncponc0558","volume":"3","author":"IB Weinstein","year":"2006","unstructured":"Weinstein IB, Joe AK . Mechanisms of disease: oncogene addiction \u2014 a rationale for molecular targeting in cancer therapy. Nat Clin Pract Oncol 2006; 3: 448\u2013457.","journal-title":"Nat Clin Pract Oncol"},{"key":"BF4402211_CR5","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/nri1568","volume":"5","author":"A Strasser","year":"2005","unstructured":"Strasser A . The role of BH3-only proteins in the immune system. Nat Rev Immunol 2005; 5: 189\u2013200.","journal-title":"Nat Rev Immunol"},{"key":"BF4402211_CR6","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/sj.leu.2403623","volume":"19","author":"WJ Mackus","year":"2005","unstructured":"Mackus WJ, Kater AP, Grummels A, Evers LM, Hooijbrink B, Kramer MH et al. Chronic lymphocytic leukemia cells display p53-dependent drug-induced Puma upregulation. Leukemia 2005; 19: 427\u2013434.","journal-title":"Leukemia"},{"key":"BF4402211_CR7","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/S1097-2765(01)00214-3","volume":"7","author":"K Nakano","year":"2001","unstructured":"Nakano K, Vousden KH . PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 2001; 7: 683\u2013694.","journal-title":"Mol Cell"},{"key":"BF4402211_CR8","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/S1097-2765(01)00213-1","volume":"7","author":"J Yu","year":"2001","unstructured":"Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B . PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 2001; 7: 673\u2013682.","journal-title":"Mol Cell"},{"key":"BF4402211_CR9","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/sj.leu.2403295","volume":"18","author":"IN Hahntow","year":"2004","unstructured":"Hahntow IN, Schneller F, Oelsner M, Weick K, Ringshausen I, Fend F et al. Cyclin-dependent kinase inhibitor Roscovitine induces apoptosis in chronic lymphocytic leukemia cells. Leukemia 2004; 18: 747\u2013755.","journal-title":"Leukemia"},{"key":"BF4402211_CR10","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1182\/blood-2006-05-020735","volume":"109","author":"JC Byrd","year":"2007","unstructured":"Byrd JC, Lin TS, Dalton JT, Wu D, Phelps MA, Fischer B et al. Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia. Blood 2007; 109: 399\u2013404.","journal-title":"Blood"},{"key":"BF4402211_CR11","doi-asserted-by":"publisher","first-page":"5399","DOI":"10.1158\/0008-5472.CAN-05-0233","volume":"65","author":"DE MacCallum","year":"2005","unstructured":"MacCallum DE, Melville J, Frame S, Watt K, Anderson S, Gianella-Borradori A et al. Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1. Cancer Res 2005; 65: 5399\u20135407.","journal-title":"Cancer Res"},{"key":"BF4402211_CR12","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1126\/science.1059108","volume":"292","author":"MC Wei","year":"2001","unstructured":"Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 2001; 292: 727\u2013730.","journal-title":"Science"},{"key":"BF4402211_CR13","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.molcel.2004.12.030","volume":"17","author":"L Chen","year":"2005","unstructured":"Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG et al. Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell 2005; 17: 393\u2013403.","journal-title":"Mol Cell"},{"key":"BF4402211_CR14","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.molcel.2005.02.003","volume":"17","author":"T Kuwana","year":"2005","unstructured":"Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR et al. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell 2005; 17: 525\u2013535.","journal-title":"Mol Cell"},{"key":"BF4402211_CR15","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1111\/j.1365-2141.1989.tb04290.x","volume":"71","author":"RJ Collins","year":"1989","unstructured":"Collins RJ, Verschuer LA, Harmon BV, Prentice RL, Pope JH, Kerr JF . Spontaneous programmed death (apoptosis) of B-chronic lymphocytic leukaemia cells following their culture in vitro. Br J Haematol 1989; 71: 343\u2013350.","journal-title":"Br J Haematol"},{"key":"BF4402211_CR16","doi-asserted-by":"publisher","first-page":"7863","DOI":"10.1038\/sj.onc.1208069","volume":"23","author":"M Herrant","year":"2004","unstructured":"Herrant M, Jacquel A, Marchetti S, Belhacene N, Colosetti P, Luciano F et al. Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis. Oncogene 2004; 23: 7863\u20137873.","journal-title":"Oncogene"},{"key":"BF4402211_CR17","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.ccr.2006.03.027","volume":"9","author":"M Certo","year":"2006","unstructured":"Certo M, Del Gaizo Moore V, Nishino M, Wei G, Korsmeyer S, Armstrong SA et al. Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell 2006; 9: 351\u2013365.","journal-title":"Cancer Cell"},{"key":"BF4402211_CR18","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1002\/eji.200425878","volume":"35","author":"P Gomez-Bougie","year":"2005","unstructured":"Gomez-Bougie P, Bataille R, Amiot M . Endogenous association of Bim BH3-only protein with Mcl-1, Bcl-xL and Bcl-2 on mitochondria in human B cells. Eur J Immunol 2005; 35: 971\u2013976.","journal-title":"Eur J Immunol"},{"key":"BF4402211_CR19","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1101\/gad.1304105","volume":"19","author":"SN Willis","year":"2005","unstructured":"Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI et al. Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev 2005; 19: 1294\u20131305.","journal-title":"Genes Dev"},{"key":"BF4402211_CR20","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.immuni.2006.03.018","volume":"24","author":"NL Alves","year":"2006","unstructured":"Alves NL, Derks IA, Berk E, Spijker R, van Lier RA, Eldering E . The Noxa\/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells. Immunity 2006; 24: 703\u2013716.","journal-title":"Immunity"},{"key":"BF4402211_CR21","doi-asserted-by":"publisher","first-page":"49795","DOI":"10.1074\/jbc.M309523200","volume":"278","author":"A Sunters","year":"2003","unstructured":"Sunters A, Fernandez de MS, Stahl M, Brosens JJ, Zoumpoulidou G, Saunders CA et al. FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. J Biol Chem 2003; 278: 49795\u201349805.","journal-title":"J Biol Chem"},{"key":"BF4402211_CR22","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.1038\/sj.onc.1206326","volume":"22","author":"G Dewson","year":"2003","unstructured":"Dewson G, Snowden RT, Almond JB, Dyer MJ, Cohen GM . Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells. Oncogene 2003; 22: 2643\u20132654.","journal-title":"Oncogene"},{"key":"BF4402211_CR23","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1038\/sj.leu.2402559","volume":"16","author":"LE van der Kolk","year":"2002","unstructured":"van der Kolk LE, Evers LM, Omene C, Lens SM, Lederman S, van Lier RA et al. CD20-induced B cell death can bypass mitochondria and caspase activation. Leukemia 2002; 16: 1735\u20131744.","journal-title":"Leukemia"},{"key":"BF4402211_CR24","doi-asserted-by":"publisher","first-page":"18407","DOI":"10.1074\/jbc.M610010200","volume":"282","author":"S Kobayashi","year":"2007","unstructured":"Kobayashi S, Lee SH, Meng XW, Mott JL, Bronk SF, Werneburg NW et al. Serine 64 phosphorylation enhances the antiapoptotic function of Mcl-1. J Biol Chem 2007; 282: 18407\u201318417.","journal-title":"J Biol Chem"},{"key":"BF4402211_CR25","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1182\/blood-2001-11-0066","volume":"100","author":"K Lin","year":"2002","unstructured":"Lin K, Sherrington PD, Dennis M, Matrai Z, Cawley JC, Pettitt AR . Relationship between p53 dysfunction, CD38 expression, and IgV(H) mutation in chronic lymphocytic leukemia. Blood 2002; 100: 1404\u20131409.","journal-title":"Blood"},{"key":"BF4402211_CR26","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/nature03579","volume":"435","author":"T Oltersdorf","year":"2005","unstructured":"Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005; 435: 677\u2013681.","journal-title":"Nature"},{"key":"BF4402211_CR27","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1038\/ncb1499","volume":"8","author":"H Kim","year":"2006","unstructured":"Kim H, Rafiuddin-Shah M, Tu HC, Jeffers JR, Zambetti GP, Hsieh JJ et al. Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies. Nat Cell Biol 2006; 8: 1348\u20131358.","journal-title":"Nat Cell Biol"},{"key":"BF4402211_CR28","doi-asserted-by":"publisher","first-page":"15313","DOI":"10.1073\/pnas.0406837101","volume":"101","author":"H Harada","year":"2004","unstructured":"Harada H, Quearry B, Ruiz-Vela A, Korsmeyer SJ . Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity. Proc Natl Acad Sci USA 2004; 101: 15313\u201315317.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF4402211_CR29","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.molcel.2004.10.028","volume":"16","author":"PF Cartron","year":"2004","unstructured":"Cartron PF, Gallenne T, Bougras G, Gautier F, Manero F, Vusio P et al. The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA. Mol Cell 2004; 16: 807\u2013818.","journal-title":"Mol Cell"},{"key":"BF4402211_CR30","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1126\/science.1133289","volume":"315","author":"SN Willis","year":"2007","unstructured":"Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE et al. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 2007; 315: 856\u2013859.","journal-title":"Science"},{"key":"BF4402211_CR31","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1083\/jcb.200606065","volume":"177","author":"RT Uren","year":"2007","unstructured":"Uren RT, Dewson G, Chen L, Coyne SC, Huang DC, Adams JM et al. Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak. J Cell Biol 2007; 177: 277\u2013287.","journal-title":"J Cell Biol"},{"key":"BF4402211_CR32","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1083\/jcb.139.5.1281","volume":"139","author":"KG Wolter","year":"1997","unstructured":"Wolter KG, Hsu YT, Smith CL, Nechushtan A, Xi XG, Youle RJ . Movement of Bax from the cytosol to mitochondria during apoptosis. J Cell Biol 1997; 139: 1281\u20131292.","journal-title":"J Cell Biol"},{"key":"BF4402211_CR33","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1126\/science.277.5324.370","volume":"277","author":"B Antonsson","year":"1997","unstructured":"Antonsson B, Conti F, Ciavatta A, Montessuit S, Lewis S, Martinou I et al. Inhibition of Bax channel-forming activity by Bcl-2. Science 1997; 277: 370\u2013372.","journal-title":"Science"},{"key":"BF4402211_CR34","doi-asserted-by":"publisher","first-page":"16223","DOI":"10.1074\/jbc.M611186200","volume":"282","author":"J Han","year":"2007","unstructured":"Han J, Goldstein LA, Hou W, Rabinowich H . Functional linkage between Noxa and Bim in mitochondrial apoptotic events. J Biol Chem 2007; 282: 16223\u201316231.","journal-title":"J Biol Chem"},{"key":"BF4402211_CR35","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.ccr.2006.10.006","volume":"10","author":"M Konopleva","year":"2006","unstructured":"Konopleva M, Contractor R, Tsao T, Samudio I, Ruvolo PP, Kitada S et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell 2006; 10: 375\u2013388.","journal-title":"Cancer Cell"},{"key":"BF4402211_CR36","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.ccr.2006.08.027","volume":"10","author":"MF van Delft","year":"2006","unstructured":"van Delft MF, Wei AH, Mason KD, Vandenberg CJ, Chen L, Czabotar PE et al. The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak\/Bax if Mcl-1 is neutralized. Cancer Cell 2006; 10: 389\u2013399.","journal-title":"Cancer Cell"},{"key":"BF4402211_CR37","first-page":"1","volume":"1","author":"LA Smit","year":"2006","unstructured":"Smit LA, Hallaert DY, Spijker R, de GB, Jaspers A, Kater AP et al. Differential Noxa\/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity. Blood 2006; 1: 1.","journal-title":"Blood"},{"key":"BF4402211_CR38","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1158\/0008-5472.CAN-06-3964","volume":"67","author":"S Chen","year":"2007","unstructured":"Chen S, Dai Y, Harada H, Dent P, Grant S . Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation. Cancer Res 2007; 67: 782\u2013791.","journal-title":"Cancer Res"},{"key":"BF4402211_CR39","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1002\/eji.200324817","volume":"34","author":"E Eldering","year":"2004","unstructured":"Eldering E, Mackus WJ, Derks IA, Evers LM, Beuling E, Teeling P et al. Apoptosis via the B cell antigen receptor requires Bax translocation and involves mitochondrial depolarization, cytochrome c release, and caspase-9 activation. Eur J Immunol 2004; 34: 1950\u20131960.","journal-title":"Eur J Immunol"},{"key":"BF4402211_CR40","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0145-2126(98)00154-4","volume":"23","author":"A Stacchini","year":"1999","unstructured":"Stacchini A, Aragno M, Vallario A, Alfarano A, Circosta P, Gottardi D et al. MEC1 and MEC2: two new cell lines derived from B-chronic lymphocytic leukaemia in prolymphocytoid transformation. Leuk Res 1999; 23: 127\u2013136.","journal-title":"Leuk Res"}],"container-title":["Cell Death &amp; Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/4402211.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/4402211","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/4402211.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:31:58Z","timestamp":1684369918000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/4402211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,17]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["BF4402211"],"URL":"https:\/\/doi.org\/10.1038\/sj.cdd.4402211","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,17]]}}}