{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T17:40:26Z","timestamp":1682358026028},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2001,10,1]],"date-time":"2001-10-01T00:00:00Z","timestamp":1001894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2001,10,1]],"date-time":"2001-10-01T00:00:00Z","timestamp":1001894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2001,10,1]]},"DOI":"10.1038\/sj.leu.2402234","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T21:04:31Z","timestamp":1032469471000},"page":"1527-1536","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Heterogeneity of VH\u2013JH gene rearrangement patterns: an insight into the biology of B cell precursor ALL"],"prefix":"10.1038","volume":"15","author":[{"given":"I","family":"Moreira","sequence":"first","affiliation":[]},{"given":"M","family":"Papaioannou","sequence":"additional","affiliation":[]},{"given":"FY","family":"Mortuza","sequence":"additional","affiliation":[]},{"given":"P","family":"Gameiro","sequence":"additional","affiliation":[]},{"given":"GL","family":"Palmisano","sequence":"additional","affiliation":[]},{"given":"CJ","family":"Harrison","sequence":"additional","affiliation":[]},{"given":"HG","family":"Prentice","sequence":"additional","affiliation":[]},{"given":"AB","family":"Mehta","sequence":"additional","affiliation":[]},{"given":"AV","family":"Hoffbrand","sequence":"additional","affiliation":[]},{"given":"L","family":"Foroni","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2001,10,4]]},"reference":[{"key":"BF2402234_CR1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/ajh.2830010202","volume":"1","author":"WW Zueler","year":"1976","unstructured":"Zueler WW, Inoue S, Thompson RI, Ottenbreit MJ . Long-term cytogenetic studies in acute leukaemia of children; the nature of relapse Am J Hematol 1976 1: 143\u2013190","journal-title":"Am J Hematol"},{"key":"BF2402234_CR2","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1182\/blood.V66.4.902.902","volume":"66","author":"LW Dow","year":"1985","unstructured":"Dow LW, Martin P, Moohr J, Greenberg M, Macdougall LG, Najfeld V, Fialkow PJ . Evidence for clonal development of childhood acute lymphoblastic leukaemia Blood 1985 66: 902\u2013907","journal-title":"Blood"},{"key":"BF2402234_CR3","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0092-8674(81)90400-1","volume":"27","author":"JV Ravetch","year":"1981","unstructured":"Ravetch JV, Siebenlist U, Korsmeyer S, Waldmann T, Leder P . Structure of the human immunoglobulin mu locus: characterisation of embryonic and rearranged J and D genes Cell 1981 27: 583\u2013591","journal-title":"Cell"},{"key":"BF2402234_CR4","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1365-2141.1990.tb02643.x","volume":"75","author":"M Brisco","year":"1990","unstructured":"Brisco M, Tan L, Osborn A, Morley A . Development of a highly sensitive assay, based on the polymerase chain reaction for rare B-lymphocyte clones in a polyclonal population Br J Haematol 1990 75: 163\u2013167","journal-title":"Br J Haematol"},{"key":"BF2402234_CR5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0161-5890(92)90100-C","volume":"29","author":"MJ Campbell","year":"1992","unstructured":"Campbell MJ, Zelenetz AD, Levy S, Levy R . Use of family-specific leader region primers for PCR amplification of the human heavy-chain variable region repertoire Mol Immunol 1992 29: 193\u2013203","journal-title":"Mol Immunol"},{"key":"BF2402234_CR6","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1365-2141.1991.tb08570.x","volume":"77","author":"M Deane","year":"1991","unstructured":"Deane M, Norton J . Immunoglobulin gene \u2018fingerprinting\u2019: an approach to analysis of B lymphoid clonality in lymphoproliferative disorders Br J Haematol 1991 77: 274\u2013281","journal-title":"Br J Haematol"},{"key":"BF2402234_CR7","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1084\/jem.165.3.879","volume":"165","author":"R Foa","year":"1987","unstructured":"Foa R, Casorati G, Giubellino MC, Basso G, Schiro R, Pizzolo G, Lauria F, Lefranc MP, Rabbitts TH, Migone N . Rearrangements of immunoglobulin and T cell receptor beta and gamma genes are associated with terminal deoxynucleotidyl transferase expression in acute myeloid leukemia J Exp Med 1987 165: 879\u2013890","journal-title":"J Exp Med"},{"key":"BF2402234_CR8","first-page":"2045","volume":"7","author":"A Beishuizen","year":"1993","unstructured":"Beishuizen A, Verhoeven MA, Mol EJ, Breit TM, Wolvers-Tettero IL, van Dongen JJ . Detection of immunoglobulin heavy-chain gene rearrangements by Southern blot analysis: recommendations for optimal results Leukemia 1993 7: 2045\u20132053","journal-title":"Leukemia"},{"key":"BF2402234_CR9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0009-8981(91)90246-9","volume":"198","author":"JJM Van Dongen","year":"1991","unstructured":"Van Dongen JJM, Wolvers-Tettero IM . Analysis of T immunoglobulin and T cell receptor genes. Part I, basic and technical aspects Clin Chim Acta 1991 198: 1\u201392","journal-title":"Clin Chim Acta"},{"key":"BF2402234_CR10","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0009-8981(91)90247-A","volume":"198","author":"JJM Van Dongen","year":"1991","unstructured":"Van Dongen JJM, Wolvers-Tettero IM . Analysis of immunoglobulin and T cell receptor genes. Part II, possibilities and limitations in the diagnosis and management of lymphoproliferative diseases and related disorders Clin Chim Acta 1991 198: 93\u2013174","journal-title":"Clin Chim Acta"},{"key":"BF2402234_CR11","first-page":"657","volume":"5","author":"A Beishuizen","year":"1991","unstructured":"Beishuizen A, Hahlen K, Kagemeijer A, Verhoven M-AJ, Hooijkaas H, Andriaansen HJ, Wolvers-Tettero ILM, Wering ER, Dongen JJM . Multiple rearranged immunoglobulin genes in childhood acute lymphoblastic leukemia of precursor B-cell origin Leukemia 1991 5: 657\u2013667","journal-title":"Leukemia"},{"key":"BF2402234_CR12","first-page":"832","volume":"5","author":"M Deane","year":"1991","unstructured":"Deane M, Pappas H, Norton JD . Immunoglobulin heavy chain gene fingerprinting reveals widespread oligoclonality in B-lineage acute lymphoblastic leukemia Leukemia 1991 5: 832\u2013838","journal-title":"Leukemia"},{"key":"BF2402234_CR13","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1182\/blood.V67.3.698.698","volume":"67","author":"GR Kitchingman","year":"1986","unstructured":"Kitchingman GR, Mirro J, Stass S, Rovigatti U, Melvin SL, Williams DL, Raimondi SC, Murphy SB . Biologic and prognostic significance of the presence of more than two mu heavy-chain genes in childhood acute lymphoblastic leukemia of B precursor cell origin Blood 1986 67: 698\u2013703","journal-title":"Blood"},{"key":"BF2402234_CR14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1046\/j.1365-2141.1996.d01-1917.x","volume":"95","author":"J Landman-Parker","year":"1996","unstructured":"Landman-Parker J, Aubin J, Delabesse E, Tabone MD, Adam M, Millien C, Leboeuf D, Buzyn-Veil A, Dollfus C, Leverger G, Macintyre EA . Simplified strategies for minimal residual disease detection in B cell precursor acute lymphoblastic leukemia Br J Haematol 1996 95: 281\u2013290","journal-title":"Br J Haematol"},{"key":"BF2402234_CR15","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1182\/blood.V82.2.581.581","volume":"82","author":"EJ Steenbergen","year":"1993","unstructured":"Steenbergen EJ, Verhagen OJHM, Leeuwen EF, Borne AEG, Schoot CE . Distinct ongoing lg heavy chain rearrangement processes in childhood B-precursor acute lymphoblastic leukemia Blood 1993 82: 581\u2013589","journal-title":"Blood"},{"key":"BF2402234_CR16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0165-4608(92)90032-4","volume":"62","author":"T Furuya","year":"1992","unstructured":"Furuya T, Morgan R, Sandberg AA . Cytogenetic biclonality in malignant hematologic disorders Cancer Genet Cytogenet 1992 62: 25\u201328","journal-title":"Cancer Genet Cytogenet"},{"key":"BF2402234_CR17","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/0165-4608(94)90120-1","volume":"72","author":"YL Kwong","year":"1994","unstructured":"Kwong YL, Lam CK, Chan AY, Lie AK, Chan LC . Cytogenetic triclonality in acute myeloid leukaemia: a morphologic, immunologic and in situ hybridization study Cancer Genet Cytogenet 1994 72: 86\u201391","journal-title":"Cancer Genet Cytogenet"},{"key":"BF2402234_CR18","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1182\/blood.V82.1.241.bloodjournal821241","volume":"82","author":"LV Abruzzo","year":"1994","unstructured":"Abruzzo LV, Schnodt K, Weiss LM, Jaffe ES, Medeiros LJ, Sander CA, M Raffeld . B-cell lymphoma after angioimmunoblastic lymphoadenopathy: a case with oligoclonal gene rearrangements associated with Epstein\u2013Barr virus Blood 1994 82: 241\u2013246","journal-title":"Blood"},{"key":"BF2402234_CR19","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1182\/blood.V85.7.1913.bloodjournal8571913","volume":"85","author":"H Aoki","year":"1995","unstructured":"Aoki H, Takishita M, Kosaka M, Saito S . Frequent somatic mutations in D and\/or JH segments of lg gene in Waldenstrom's macroglobulinemia and chronic lymphocytic leukemia (CLL) with Richter's syndrome but not in common CLL Blood 1995 85: 1913\u20131919","journal-title":"Blood"},{"key":"BF2402234_CR20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/gcc.2870080109","volume":"8","author":"PE Crossen","year":"1993","unstructured":"Crossen PE, Tully SM, Benjes SM, Hollings PE, Beard ME, Nimmo JC, Morrison MJ . Oligoclonal B-cell leukemia characterized by spontaneous cell division and telomere association Genes Chromos Cancer 1993 8: 49\u201359","journal-title":"Genes Chromos Cancer"},{"key":"BF2402234_CR21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3109\/10428199409049651","volume":"14","author":"AS Korganow","year":"1994","unstructured":"Korganow AS, Martin T, Weber JC, Lioure B, Lutz P, Knapp AM, Pasquali JL . Molecular analysis of rearranged VH genes during B cell chronic lymphocytic leukemia: intraclonal stability is frequent but not constant Leuk Lymphoma 1994 14: 55\u201369","journal-title":"Leuk Lymphoma"},{"key":"BF2402234_CR22","first-page":"1551","volume":"10","author":"K Stamatopoulos","year":"1996","unstructured":"Stamatopoulos K, Kosmas C, Stavroyianni N, Loukopoulos D . Evidence for immunoglobulin heavy chain variable region gene replacement in a patient with B cell chronic lymphocytic leukemia Leukemia 1996 10: 1551\u20131556","journal-title":"Leukemia"},{"key":"BF2402234_CR23","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1600-0609.1999.tb01765.x","volume":"63","author":"R Rosenquist","year":"1999","unstructured":"Rosenquist R, Thunberg U, Li AH, Forestier E, Lonnerholm G, Lindh J, Sundstrom C, Sallstrom J, Holmberg D, Roos G . Clonal evolution as judged by immunoglobulin heavy chain gene rearrangements in relapsing precursor-B acute lymphoblastic leukemia Eur J Haematol 1999 63: 171\u2013179","journal-title":"Eur J Haematol"},{"key":"BF2402234_CR24","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1182\/blood.V83.8.2238.2238","volume":"83","author":"A Beishuizen","year":"1994","unstructured":"Beishuizen A, Verhoeven MA, van Wering ER, Hahlen K, Hooijkaas H, van Dongen JJ . Analysis of lg and T-cell receptor genes in 40 childhood acute lymphoblastic leukemias at diagnosis and subsequent relapse: implications for the detection of minimal residual disease by polymerase chain reaction analysis Blood 1994 83: 2238\u20132247","journal-title":"Blood"},{"key":"BF2402234_CR25","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/S0140-6736(98)04058-6","volume":"352","author":"JJ van Dongen","year":"1998","unstructured":"van Dongen JJ, Seriu T, Panzer-Grumayer ER, Biondi A, Pongers-Willemse MJ, Corral L, Stolz F, Schrappe M, Masera G, Kamps WA, Gadner H, van Wering ER, Ludwig WD, Basso G, de Bruijn MA, Cazzaniga G, Hettinger K, van der Does-van den Berg A, Hop WC, Riehm H, Bartram CR . Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood Lancet 1998 352: 1731\u20131738","journal-title":"Lancet"},{"key":"BF2402234_CR26","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1365-2141.1989.tb00249.x","volume":"73","author":"F Katz","year":"1989","unstructured":"Katz F, Ball L, Gibbons B, Chessels J . The use of DNA probes to monitor minimal residual disease in childhood acute leukaemia Br J Haematol 1989 73: 173\u2013180","journal-title":"Br J Haematol"},{"key":"BF2402234_CR27","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/S0145-2126(99)00121-6","volume":"23","author":"E Kressler","year":"1999","unstructured":"Kressler E, Panzer S, Ghali DW, Haas OA, Gadner H, Panzer-Grumayer ER . Heterogeneous TCR delta VNDelta2-Ddelta3 rearrangements and their relation to lgH and TCR gamma gene status in childhood B cell precursor leukaemias Leukemia Res 1999 23: 1089\u20131096","journal-title":"Leukemia Res"},{"key":"BF2402234_CR28","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1093\/intimm\/2.6.579","volume":"2","author":"LR Covey","year":"1990","unstructured":"Covey LR, Ferrier P, Alt FW . VH to VHDNJH rearrangement is mediated by the internal VH heptamer Int Immunol 1990 2: 579\u2013583","journal-title":"Int Immunol"},{"key":"BF2402234_CR29","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/j.1460-2075.1992.tb05093.x","volume":"11","author":"S Usuda","year":"1992","unstructured":"Usuda S, Takemori T, Matsuoka M, Shirasawa T, Yoshida K, Mori A, Ishizaka K, Sakano H . Immunoglobulin V gene replacement is caused by the intramolecular DNA deletion mechanism EMBO J 1992 11: 611\u2013618","journal-title":"EMBO J"},{"key":"BF2402234_CR30","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.4049\/jimmunol.142.10.3652","volume":"142","author":"T Maeda","year":"1989","unstructured":"Maeda T, Sugiyama H, Tani Y, Kishimoyo S . The DNJH complex remains active in recombination to VH segments after the loss of mu-chain expression in mu-positive pre-B cells J Immunol 1989 142: 3652\u20133656","journal-title":"J Immunol"},{"key":"BF2402234_CR31","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/eji.1830230233","volume":"23","author":"T Komori","year":"1993","unstructured":"Komori T, Minami Y, Sakato N, Sugiyama H . Biased usage of two restricted VH gene segments in VH replacement Eur J Immunol 1993 23: 517\u2013522","journal-title":"Eur J Immunol"},{"key":"BF2402234_CR32","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/322840a0","volume":"322","author":"M Reth","year":"1986","unstructured":"Reth M, Gehrmann P, Petrac E, Wiese P . A novel VH to VHDNJH joining mechanism in heavy-chain-negative (null) pre B cells results in heavy-chain production Nature 1986 322: 840\u2013842","journal-title":"Nature"},{"key":"BF2402234_CR33","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1084\/jem.168.1.229","volume":"168","author":"J Bird","year":"1988","unstructured":"Bird J, Galili N, Link M, Stites D, Sklar J . Continuing rearrangement, but absence of somatic hypermutation in immunoglobulin genes of human B cell precursor leukemia J Exp Med 1988 168: 229\u2013245","journal-title":"J Exp Med"},{"key":"BF2402234_CR34","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1182\/blood.V87.6.2506.bloodjournal8762506","volume":"87","author":"Y Choi","year":"1996","unstructured":"Choi Y, Greenberg SJ, Du T-L, Ward PM, Overturf PM, Bretcher ML, Ballow M . Clonal evolution in B-lineage acute lymphoblastic leukemia by contemporaneous VH-VH gene replacements and VH-DNJH gene rearrangements Blood 1996 87: 2506\u20132512","journal-title":"Blood"},{"key":"BF2402234_CR35","first-page":"1213","volume":"6","author":"CG Steward","year":"1992","unstructured":"Steward CG, Potter M, Oakhill A . Third complementarity determining region (CDR-III) sequence analysis in childhood B-lineage acute lymphoblastic leukemia: implications for the design of oligonucleotides for use in monitoring minimal residual disease Leukemia 1992 6: 1213\u20131219","journal-title":"Leukemia"},{"key":"BF2402234_CR36","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1182\/blood.V79.1.223.223","volume":"79","author":"R Wasserman","year":"1992","unstructured":"Wasserman R, Yamada M, Ito Y, Finger LR, Reichard BA, Shane S, Lange B, Rovera G . VH gene rearrangement event can modify immunoglobulin heavy chain during progression of B-lineage acute lymphoblastic leukemia Blood 1992 79: 223\u2013228","journal-title":"Blood"},{"key":"BF2402234_CR37","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1182\/blood.V85.10.2795.bloodjournal85102795","volume":"85","author":"DW Ghali","year":"1995","unstructured":"Ghali DW, Panzer S, Fischer S, Argyriou-Tirita A, Haas OA, Kovar H, Gadner H, Panzer-Grumayer ER . Heterogeneity of the T-cell receptor delta gene indicating subclone formation in acute precursor B-cell leukemias Blood 1995 85: 2795\u20132801","journal-title":"Blood"},{"key":"BF2402234_CR38","first-page":"205","volume":"246","author":"T Szczepanski","year":"1999","unstructured":"Szczepanski T, Pongers-Willemse MJ, Langerak AW, van Dongen JJ . Unusual immunoglobulin and T-cell receptor gene rearrangement patterns in acute lymphoblastic leukemias Curr Top Microbiol Immunol 1999 246: 205\u2013215","journal-title":"Curr Top Microbiol Immunol"},{"key":"BF2402234_CR39","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1046\/j.1365-2141.1996.289831.x","volume":"92","author":"JS Chim","year":"1996","unstructured":"Chim JS, Coyle L, Yaxley JC, Cole Sinclair MF, Cannell PK, Hoffbrand AV, Foroni L . The use of IgH fingerprinting and ASO-dependent PCR for the investigation of residual disease (MRD) in ALL Br J Haematol 1996 92: 104\u2013115","journal-title":"Br J Haematol"},{"key":"BF2402234_CR40","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1046\/j.1365-2141.1996.d01-1851.x","volume":"94","author":"LA Coyle","year":"1996","unstructured":"Coyle LA, Papaioannou M, Yaxley JC, Chim JC, Attard M, Hoffbrand AV, Foroni L . Molecular analysis of the leukaemic B cell in adult and childhood acute lymphoblastic leukaemia Br J Haematol 1996 94: 685\u2013693","journal-title":"Br J Haematol"},{"key":"BF2402234_CR41","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/sj.leu.2401071","volume":"12","author":"T Szczepanski","year":"1998","unstructured":"Szczepanski T, Langerak AW, Wolvers-Tettero IL, Ossenkoppele GJ, Verhoef G, Stul M, Petersen EJ, de Bruijn MA, van't Veer MB, van Dongen JJ . Immunoglobulin and T cell receptor gene rearrangement patterns in acute lymphoblastic leukemia are less mature in adults than in children: implications for selection of PCR targets for detection of minimal residual disease Leukemia 1998 12: 1081\u20131088","journal-title":"Leukemia"},{"key":"BF2402234_CR42","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0167-5699(95)80166-9","volume":"16","author":"GP Cook","year":"1995","unstructured":"Cook GP, Tomlinson IM . The human immunoglobulin VH repertoire Immunol Today 1995 16: 237\u2013242","journal-title":"Immunol Today"},{"key":"BF2402234_CR43","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1084\/jem.188.11.2151","volume":"188","author":"F Matsuda","year":"1998","unstructured":"Matsuda F, Ishii K, Bourvagnet P, Kuna K, Hayashida H, Miyata T, Honjo T . The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus J Exp Med 1998 188: 2151\u20132162","journal-title":"J Exp Med"},{"key":"BF2402234_CR44","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1600-0609.1999.tb01880.x","volume":"63","author":"AH Li","year":"1999","unstructured":"Li AH, Rosenquist R, Forestier E, Holmberg D, Lindh J, Lofvenberg E, Roos G . Clonal rearrangements in childhood and adult acute lymphoblastic leukemia: a comparative polymerase chain reaction study using multiple sets of primers Eur J Haematol 1999 63: 211\u2013218","journal-title":"Eur J Haematol"},{"key":"BF2402234_CR45","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/sj.bjc.6690183","volume":"79","author":"Y-M Zhu","year":"1999","unstructured":"Zhu Y-M, Foroni L, McQuaker IG, Papaioannou M, Haynes A, Russell N . Mechanisms of relapse in acute lymphoblastic leukemia: involvement of p53 mutated subclones in disease progression Br J Cancer 1999 79: 1151\u20131157","journal-title":"Br J Cancer"},{"key":"BF2402234_CR46","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1182\/blood.V97.9.2716","volume":"97","author":"FY Mortuza","year":"2001","unstructured":"Mortuza FY, Moreira I, Papaioannou, Coyle LA, Gricks C, Amlot P, Prentice HG, Hoffbrand AV, Foroni L . Immunoglobulin heavy chain gene rearrangement in adult acute lymphoblastic leukemia reveals preference of JH-proximal variable gene segments Blood 2001 97: 2716\u20132726","journal-title":"Blood"},{"key":"BF2402234_CR47","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1182\/blood.V92.9.3422","volume":"92","author":"K Nafa","year":"1998","unstructured":"Nafa K, Bessler M, Deeg HJ, Luzzatto L . New somatic mutation in the PIG-A gene emerges at relapse of paroxysmal nocturnal hemoglobinuria Blood 1998 92: 3422\u20133427","journal-title":"Blood"},{"key":"BF2402234_CR48","doi-asserted-by":"crossref","first-page":"5242","DOI":"10.1182\/blood.V87.12.5242.bloodjournal87125242","volume":"87","author":"SE Height","year":"1996","unstructured":"Height SE, Swansbury GJ, Matutes E, Treleaven JG, Catovsky D, Dyer MJS . Analysis of clonal rearrangements of the lg heavy chain locus in acute leukemia Blood 1996 87: 5242\u20135250","journal-title":"Blood"},{"key":"BF2402234_CR49","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1182\/blood.V83.5.1355.1355","volume":"83","author":"CG Steward","year":"1994","unstructured":"Steward CG, Goulden NJ, Katz F, Martin PG, Langlands K, Potter MN, Chessel JM, Oakhill AA . PCR study of the stability of IgH heavy chain and T cell receptor \u03b4 gene rearrangements between presentation and relapse of childhood B lineage acute lymphoblastic leukemia Blood 1994 83: 1355\u20131362","journal-title":"Blood"},{"key":"BF2402234_CR50","first-page":"1779","volume":"9","author":"MD Norris","year":"1995","unstructured":"Norris MD, Kwan E, Haber M, Marshall GM . Detection of evolving immunoglobulin heavy-chain gene rearrangements in acute lymphoblastic leukemia: a PCR-based assay employing overlapping DNJH primers Leukemia 1995 9: 1779\u20131782","journal-title":"Leukemia"},{"key":"BF2402234_CR51","first-page":"3724","volume":"90","author":"GL Palmisano","year":"1997","unstructured":"Palmisano GL, Papaioannou M, Moreira I, Foroni L . Immunoglobulin vs V\u03b42-D\u03b43 rearrangement in B lineage ALL: IgH must remain the marker of choice for MRD investigation Blood 1997 90: (Suppl. 1) 3724\u2013220b (Abstr.)","journal-title":"Blood"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2402234.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2402234","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2402234.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T17:19:35Z","timestamp":1682356775000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2402234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10,1]]},"references-count":51,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2001,10,1]]}},"alternative-id":["BF2402234"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2402234","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,10,1]]},"assertion":[{"value":"26 December 2000","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2001","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2001","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}