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In <jats:italic>Drosophila<\/jats:italic>, the steroid hormone ecdysone controls developmental transitions, thereby regulating the duration of the growth period. Here we show that ecdysone promotes the growth of imaginal discs in mid-third instar larvae, since imaginal discs from larvae with reduced or no ecdysone synthesis are smaller than wild type due to smaller and fewer cells. We show that insulin-like peptides are produced and secreted normally in larvae with reduced ecdysone synthesis and upstream components of insulin\/insulin-like signaling are activated in their discs. Instead, ecdysone appears to regulate the growth of imaginal discs via <jats:italic>Thor\/4E-BP<\/jats:italic>, a negative growth regulator downstream of the insulin\/insulin-like growth factor\/Tor pathways. Discs from larvae with reduced ecdysone synthesis have elevated levels of <jats:italic>Thor<\/jats:italic>, while mutations in <jats:italic>Thor<\/jats:italic> partially rescue their growth. The regulation of organ growth by ecdysone is evolutionarily conserved in hemimetabolous insects, as shown by our results obtained using <jats:italic>Blattella germanica<\/jats:italic>. In summary, our data provide new insights into the relationship between components of the insulin\/insulin-like\/Tor and ecdysone pathways in the control of organ growth.<\/jats:p>","DOI":"10.1038\/srep12383","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T09:54:33Z","timestamp":1437558873000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Ecdysone promotes growth of imaginal discs through the regulation of Thor in D. melanogaster"],"prefix":"10.1038","volume":"5","author":[{"given":"Leire","family":"Herboso","sequence":"first","affiliation":[]},{"given":"Marisa M.","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Talamillo","sequence":"additional","affiliation":[]},{"given":"Coralia","family":"P\u00e9rez","sequence":"additional","affiliation":[]},{"given":"Monika","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[]},{"given":"David","family":"Mart\u00edn","sequence":"additional","affiliation":[]},{"given":"James D.","family":"Sutherland","sequence":"additional","affiliation":[]},{"given":"Alexander W.","family":"Shingleton","sequence":"additional","affiliation":[]},{"given":"Christen K.","family":"Mirth","sequence":"additional","affiliation":[]},{"given":"Rosa","family":"Barrio","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2015,7,22]]},"reference":[{"key":"BFsrep12383_CR1","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1002\/bies.20552","volume":"29","author":"CK Mirth","year":"2007","unstructured":"Mirth, C. 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