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To date the HCV origin remains unclear and HCV life cycle and pathogenesis are not enlightened processes due to the absence of HCV efficient cell cultures systems or animals models. Here we show that rabbit and hare HCV-like viruses, RHCV and HHCV respectively, are formed after the inoculation of genomic DNA in Madin-Darby bovine kidney cell line cultures. RHCV is closely related to the HCV-1a\/HCV-1b genotypes and HHCV is more closely related to the HCV-1b genotype. These findings could contribute to the understanding of HCV origin as well as clarify the virus life cycle, pathogenesis, evolution and diversity.<\/jats:p>","DOI":"10.1038\/srep14535","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T09:11:04Z","timestamp":1443517864000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hepatitis C-like viruses are produced in cells from rabbit and hare DNA"],"prefix":"10.1038","volume":"5","author":[{"given":"Eliane","family":"Silva","sequence":"first","affiliation":[]},{"given":"Hugo","family":"Os\u00f3rio","sequence":"additional","affiliation":[]},{"given":"Gertrude","family":"Thompson","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2015,9,29]]},"reference":[{"key":"BFsrep14535_CR1","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nrmicro1645","volume":"5","author":"D Moradpour","year":"2007","unstructured":"Moradpour, D., Penin, F. & Rice, C. 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