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We therefore hypothesised that some lower-risk genetic variants might also predispose to both CRC and EC. Using CRC and EC genome-wide association series, totalling 13,265 cancer cases and 40,245 controls, we found that the protective allele [G] at one previously-identified CRC polymorphism, rs2736100 near <jats:italic>TERT<\/jats:italic>, was associated with EC risk (odds ratio (OR)\u2009=\u20091.08, P\u2009=\u20090.000167); this polymorphism influences the risk of several other cancers. A further CRC polymorphism near <jats:italic>TERC<\/jats:italic> also showed evidence of association with EC (OR\u2009=\u20090.92; P\u2009=\u20090.03). Overall, however, there was no good evidence that the set of CRC polymorphisms was associated with EC risk and neither of two previously-reported EC polymorphisms was associated with CRC risk. A combined analysis revealed one genome-wide significant polymorphism, rs3184504, on chromosome 12q24 (OR\u2009=\u20091.10, P\u2009=\u20097.23\u2009\u00d7\u200910<jats:sup>\u22129<\/jats:sup>) with shared effects on CRC and EC risk. This polymorphism, a missense variant in the gene <jats:italic>SH2B3<\/jats:italic>, is also associated with haematological and autoimmune disorders, suggesting that it influences cancer risk through the immune response. Another polymorphism, rs12970291 near gene <jats:italic>TSHZ1<\/jats:italic>, was associated with both CRC and EC (OR\u2009=\u20091.26, P\u2009=\u20094.82\u2009\u00d7\u200910<jats:sup>\u22128<\/jats:sup>), with the alleles showing opposite effects on the risks of the two cancers.<\/jats:p>","DOI":"10.1038\/srep17369","type":"journal-article","created":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T09:55:45Z","timestamp":1448963745000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1"],"prefix":"10.1038","volume":"5","author":[{"given":"Timothy 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