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Here, we demonstrate that vMIA is also localized at peroxisomes, induces their fragmentation and inhibits the peroxisomal-dependent antiviral signalling pathway. Importantly, we demonstrate that peroxisomal fragmentation is not essential for vMIA to specifically inhibit signalling downstream the peroxisomal MAVS. We also show that vMIA interacts with the cytoplasmic chaperone Pex19, suggesting that the virus has developed a strategy to highjack the peroxisomal membrane proteins\u2019 transport machinery. Furthermore, we show that vMIA is able to specifically interact with the peroxisomal MAVS. Our results demonstrate that peroxisomes constitute a platform for evasion of the cellular antiviral response and that the human cytomegalovirus has developed a mechanism by which it is able to specifically evade the peroxisomal MAVS-dependent antiviral signalling.<\/jats:p>","DOI":"10.1038\/srep26028","type":"journal-article","created":{"date-parts":[[2016,5,16]],"date-time":"2016-05-16T09:14:58Z","timestamp":1463390098000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Peroxisomes are platforms for cytomegalovirus\u2019 evasion from the cellular immune response"],"prefix":"10.1038","volume":"6","author":[{"given":"Ana Cristina","family":"Magalh\u00e3es","sequence":"first","affiliation":[]},{"given":"Ana Rita","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"S\u00edlvia","family":"Gomes","sequence":"additional","affiliation":[]},{"given":"Marta","family":"Vieira","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Gouveia","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Valen\u00e7a","sequence":"additional","affiliation":[]},{"given":"Markus","family":"Islinger","sequence":"additional","affiliation":[]},{"given":"Rute","family":"Nascimento","sequence":"additional","affiliation":[]},{"given":"Michael","family":"Schrader","sequence":"additional","affiliation":[]},{"given":"Jonathan C.","family":"Kagan","sequence":"additional","affiliation":[]},{"given":"Daniela","family":"Ribeiro","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2016,5,16]]},"reference":[{"key":"BFsrep26028_CR1","unstructured":"Mocarski, E. 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