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Maintaining pangolins in captivity is a significant challenge, in part because little is known about their genetics. Here we provide the first large-scale sequencing of the critically endangered <jats:italic>Manis javanica<\/jats:italic> transcriptomes from eight\u2009different organs using Illumina HiSeq technology, yielding ~75 Giga bases and 89,754 unigenes. We found some unigenes involved in the insect hormone biosynthesis pathway and also 747 lipids metabolism-related unigenes that may be insightful to understand the lipid metabolism system in pangolins. Comparative analysis between <jats:italic>M. javanica<\/jats:italic> and other mammals revealed many pangolin-specific genes significantly over-represented in stress-related processes, cell proliferation and external stimulus, probably reflecting the traits and adaptations of the analyzed pregnant female <jats:italic>M. javanica<\/jats:italic>. Our study provides an invaluable resource for future functional works that may be highly relevant for the conservation of pangolins.<\/jats:p>","DOI":"10.1038\/srep28199","type":"journal-article","created":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T09:02:36Z","timestamp":1473757356000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["De novo sequencing, assembly and analysis of eight different transcriptomes from the Malayan pangolin"],"prefix":"10.1038","volume":"6","author":[{"given":"Aini","family":"Mohamed Yusoff","sequence":"first","affiliation":[]},{"given":"Tze King","family":"Tan","sequence":"additional","affiliation":[]},{"given":"Ranjeev","family":"Hari","sequence":"additional","affiliation":[]},{"given":"Klaus-Peter","family":"Koepfli","sequence":"additional","affiliation":[]},{"given":"Wei Yee","family":"Wee","sequence":"additional","affiliation":[]},{"given":"Agostinho","family":"Antunes","sequence":"additional","affiliation":[]},{"given":"Frankie Thomas","family":"Sitam","sequence":"additional","affiliation":[]},{"given":"Jeffrine Japning","family":"Rovie-Ryan","sequence":"additional","affiliation":[]},{"given":"Kayal Vizi","family":"Karuppannan","sequence":"additional","affiliation":[]},{"given":"Guat Jah","family":"Wong","sequence":"additional","affiliation":[]},{"given":"Leonard","family":"Lipovich","sequence":"additional","affiliation":[]},{"given":"Wesley C.","family":"Warren","sequence":"additional","affiliation":[]},{"given":"Stephen J.","family":"O\u2019Brien","sequence":"additional","affiliation":[]},{"given":"Siew Woh","family":"Choo","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2016,9,13]]},"reference":[{"key":"BFsrep28199_CR1","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1093\/icb\/41.3.507","volume":"41","author":"KZ Reiss","year":"2001","unstructured":"Reiss, K. 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