{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:17:58Z","timestamp":1774937878615,"version":"3.50.1"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T00:00:00Z","timestamp":1471910400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T00:00:00Z","timestamp":1471910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous results indicated that miR-146b-5p is downregulated by TAL1, a transcription factor critical for early hematopoiesis that is frequently overexpressed in T-cell acute lymphoblastic leukemia (T-ALL) where it has an oncogenic role. Here, we confirmed that miR-146b-5p expression is lower in TAL1-positive patient samples than in other T-ALL cases. Furthermore, leukemia T-cells display decreased levels of miR-146b-5p as compared to normal T-cells, thymocytes and other hematopoietic progenitors. MiR-146b-5p silencing enhances the <jats:italic>in vitro<\/jats:italic> migration and invasion of T-ALL cells, associated with increased levels of filamentous actin and chemokinesis. <jats:italic>In vivo<\/jats:italic>, miR-146b overexpression in a TAL1-positive cell line extends mouse survival in a xenotransplant model of human T-ALL. In contrast, knockdown of miR-146b-5p results in leukemia acceleration and decreased mouse overall survival, paralleled by faster tumor infiltration of the central nervous system. Our results suggest that miR-146b-5p is a functionally relevant microRNA gene in the context of T-ALL, whose negative regulation by TAL1 and possibly other oncogenes contributes to disease progression by modulating leukemia cell motility and disease aggressiveness.<\/jats:p>","DOI":"10.1038\/srep31894","type":"journal-article","created":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T09:33:29Z","timestamp":1471944809000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["MiR-146b negatively regulates migration and delays progression of T-cell acute lymphoblastic leukemia"],"prefix":"10.1038","volume":"6","author":[{"given":"N\u00e1dia C.","family":"Correia","sequence":"first","affiliation":[]},{"given":"Rita","family":"Fragoso","sequence":"additional","affiliation":[]},{"given":"T\u00e2nia","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Francisco J.","family":"Enguita","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o T.","family":"Barata","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2016,8,23]]},"reference":[{"key":"BFsrep31894_CR1","doi-asserted-by":"crossref","unstructured":"DeAngelo, D. J. The treatment of adolescents and young adults with acute lymphoblastic leukemia. Hematology Am Soc Hematol Educ Program, 123\u201330 (2005).","DOI":"10.1182\/asheducation-2005.1.123"},{"key":"BFsrep31894_CR2","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1053\/j.seminhematol.2013.06.007","volume":"50","author":"CH Pui","year":"2013","unstructured":"Pui, C. H. & Evans, W. E. A 50-year journey to cure childhood acute lymphoblastic leukemia. Semin Hematol 50, 185\u201396 (2013).","journal-title":"Semin Hematol"},{"key":"BFsrep31894_CR3","doi-asserted-by":"publisher","first-page":"3616","DOI":"10.1200\/JCO.2003.10.116","volume":"21","author":"JM Goldberg","year":"2003","unstructured":"Goldberg, J. M. et al. Childhood T-cell acute lymphoblastic leukemia: the Dana-Farber Cancer Institute acute lymphoblastic leukemia consortium experience. J Clin Oncol 21, 3616\u201322 (2003).","journal-title":"J Clin Oncol"},{"key":"BFsrep31894_CR4","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1038\/nature03315","volume":"433","author":"LP Lim","year":"2005","unstructured":"Lim, L. P. et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433, 769\u2013773 (2005).","journal-title":"Nature"},{"key":"BFsrep31894_CR5","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","volume":"116","author":"DP Bartel","year":"2004","unstructured":"Bartel, D. P. MicroRNAs: Genomics, Biogenesis, Mechanism, and Function. Cell 116, 281\u2013297 (2004).","journal-title":"Cell"},{"key":"BFsrep31894_CR6","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.1073\/pnas.0307323101","volume":"101","author":"GA Calin","year":"2004","unstructured":"Calin, G. A. et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proceedings of the National Academy of Sciences of the United States of America 101, 2999\u20133004 (2004).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"BFsrep31894_CR7","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.semcancer.2008.01.002","volume":"18","author":"C Kanellopoulou","year":"2008","unstructured":"Kanellopoulou, C. & Monticelli, S. A role for microRNAs in the development of the immune system and in the pathogenesis of cancer. Semin Cancer Biol 18, 79\u201388 (2008).","journal-title":"Semin Cancer Biol"},{"key":"BFsrep31894_CR8","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/nature03702","volume":"435","author":"J Lu","year":"2005","unstructured":"Lu, J. et al. MicroRNA expression profiles classify human cancers. Nature 435, 834\u2013838 (2005).","journal-title":"Nature"},{"key":"BFsrep31894_CR9","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1080\/10428190802535114","volume":"50","author":"M Fabbri","year":"2009","unstructured":"Fabbri, M., Croce, C. M. & Calin, G. A. MicroRNAs in the ontogeny of leukemias and lymphomas. Leukemia & Lymphoma 50, 160\u2013170 (2009).","journal-title":"Leukemia & Lymphoma"},{"key":"BFsrep31894_CR10","doi-asserted-by":"crossref","unstructured":"Schotte, D. et al. MicroRNAs characterize genetic diversity and drug resistance in pediatric acute lymphoblastic leukemia. Haematologica (2011).","DOI":"10.3324\/haematol.2010.026138"},{"key":"BFsrep31894_CR11","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.leukres.2011.10.005","volume":"36","author":"JC de Oliveira","year":"2012","unstructured":"de Oliveira, J. C. et al. Differential MiRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features. Leukemia Research 36, 293\u2013298 (2012).","journal-title":"Leukemia Research"},{"key":"BFsrep31894_CR12","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/ncb2037","volume":"12","author":"KJ Mavrakis","year":"2010","unstructured":"Mavrakis, K. J. et al. Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia. Nat Cell Biol 12, 372\u2013379 (2010).","journal-title":"Nat Cell Biol"},{"key":"BFsrep31894_CR13","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/ng.858","volume":"43","author":"KJ Mavrakis","year":"2011","unstructured":"Mavrakis, K. J. et al. A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL). Nat Genet 43, 673\u2013678 (2011).","journal-title":"Nat Genet"},{"key":"BFsrep31894_CR14","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1038\/leu.2011.273","volume":"26","author":"M Lv","year":"2012","unstructured":"Lv, M. et al. An oncogenic role of miR-142-3p in human T-cell acute lymphoblastic leukemia (T-ALL) by targeting glucocorticoid receptor-[alpha] and cAMP\/PKA pathways. Leukemia 26, 769\u2013777 (2012).","journal-title":"Leukemia"},{"key":"BFsrep31894_CR15","doi-asserted-by":"crossref","unstructured":"Kumar, V. et al. Notch and NF-kB signaling pathways regulate miR-223\/FBXW7 axis in T-cell acute lymphoblastic leukemia. Leukemia (2014).","DOI":"10.1038\/leu.2014.133"},{"key":"BFsrep31894_CR16","doi-asserted-by":"publisher","first-page":"ra111","DOI":"10.1126\/scisignal.2005500","volume":"7","author":"VR Sanghvi","year":"2014","unstructured":"Sanghvi, V. R. et al. Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia. Sci Signal 7, ra111 (2014).","journal-title":"Sci Signal"},{"key":"BFsrep31894_CR17","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1038\/373432a0","volume":"373","author":"RA Shivdasani","year":"1995","unstructured":"Shivdasani, R. A., Mayer, E. L. & Orkin, S. H. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1\/SCL. Nature 373, 432\u20134 (1995).","journal-title":"Nature"},{"key":"BFsrep31894_CR18","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0092-8674(00)80076-8","volume":"86","author":"C Porcher","year":"1996","unstructured":"Porcher, C. et al. The T cell leukemia oncoprotein SCL\/tal-1 is essential for development of all hematopoietic lineages. Cell 86, 47\u201357 (1996).","journal-title":"Cell"},{"key":"BFsrep31894_CR19","doi-asserted-by":"publisher","first-page":"2998","DOI":"10.1182\/blood-2006-05-022988","volume":"108","author":"P Brunet de la Grange","year":"2006","unstructured":"Brunet de la Grange, P. et al. Low SCL\/TAL1 expression reveals its major role in adult hematopoietic myeloid progenitors and stem cells. Blood 108, 2998\u20133004 (2006).","journal-title":"Blood"},{"key":"BFsrep31894_CR20","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1182\/blood-2005-02-0557","volume":"106","author":"D Reynaud","year":"2005","unstructured":"Reynaud, D. et al. SCL\/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment. Blood 106, 2318\u201328 (2005).","journal-title":"Blood"},{"key":"BFsrep31894_CR21","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1634\/stemcells.2004-0260","volume":"23","author":"Y Zhang","year":"2005","unstructured":"Zhang, Y. et al. SCL expression at critical points in human hematopoietic lineage commitment. Stem Cells 23, 852\u201360 (2005).","journal-title":"Stem Cells"},{"key":"BFsrep31894_CR22","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1182\/blood.V86.2.666.bloodjournal862666","volume":"86","author":"RO Bash","year":"1995","unstructured":"Bash, R. O. et al. Does activation of the TAL1 gene occur in a majority of patients with T- cell acute lymphoblastic leukemia? A pediatric oncology group study. Blood 86, 666\u2013676 (1995).","journal-title":"Blood"},{"key":"BFsrep31894_CR23","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S1535-6108(02)00018-1","volume":"1","author":"AA Ferrando","year":"2002","unstructured":"Ferrando, A. A. et al. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell 1, 75\u201387 (2002).","journal-title":"Cancer Cell"},{"key":"BFsrep31894_CR24","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1038\/leu.2011.140","volume":"25","author":"BA Cardoso","year":"2011","unstructured":"Cardoso, B. A. et al. TAL1\/SCL is downregulated upon histone deacetylase inhibition in T-cell acute lymphoblastic leukemia cells. Leukemia 25, 1578\u201386 (2011).","journal-title":"Leukemia"},{"key":"BFsrep31894_CR25","doi-asserted-by":"publisher","first-page":"4576","DOI":"10.1074\/jbc.272.7.4576","volume":"272","author":"Y Ono","year":"1997","unstructured":"Ono, Y., Fukuhara, N. & Yoshie, O. Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL. J Biol Chem 272, 4576\u201381 (1997).","journal-title":"J Biol Chem"},{"key":"BFsrep31894_CR26","doi-asserted-by":"publisher","first-page":"6939","DOI":"10.1128\/MCB.18.12.6939","volume":"18","author":"Y Ono","year":"1998","unstructured":"Ono, Y., Fukuhara, N. & Yoshie, O. TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3. Mol Cell Biol 18, 6939\u201350 (1998).","journal-title":"Mol Cell Biol"},{"key":"BFsrep31894_CR27","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1093\/intimm\/10.10.1539","volume":"10","author":"M Bernard","year":"1998","unstructured":"Bernard, M. et al. Helix-loop-helix (E2-5, HEB, TAL1 and Id1) protein interaction with the TCRalphadelta enhancers. Int Immunol 10, 1539\u201349 (1998).","journal-title":"Int Immunol"},{"key":"BFsrep31894_CR28","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/77819","volume":"1","author":"S Herblot","year":"2000","unstructured":"Herblot, S., Steff, A. M., Hugo, P., Aplan, P. D. & Hoang, T. SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression. Nat Immunol 1, 138\u201344 (2000).","journal-title":"Nat Immunol"},{"key":"BFsrep31894_CR29","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.bbrc.2003.11.030","volume":"312","author":"A Hansson","year":"2003","unstructured":"Hansson, A., Manetopoulos, C., J\u00f6nsson, J.-I. & Axelson, H. The basic helix\u2013loop\u2013helix transcription factor TAL1\/SCL inhibits the expression of the p16INK4A and pT\u03b1 genes. Biochemical and Biophysical Research Communications 312, 1073\u20131081 (2003).","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"BFsrep31894_CR30","doi-asserted-by":"publisher","first-page":"6008","DOI":"10.1158\/0008-5472.CAN-06-0194","volume":"66","author":"PY Chang","year":"2006","unstructured":"Chang, P. Y., Draheim, K., Kelliher, M. A. & Miyamoto, S. NFKB1 is a direct target of the TAL1 oncoprotein in human T leukemia cells. Cancer Res 66, 6008\u201313 (2006).","journal-title":"Cancer Res"},{"key":"BFsrep31894_CR31","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1182\/blood-2005-08-3482","volume":"108","author":"T Palomero","year":"2006","unstructured":"Palomero, T. et al. Transcriptional regulatory networks downstream of TAL1\/SCL in T-cell acute lymphoblastic leukemia. Blood 108, 986\u2013992 (2006).","journal-title":"Blood"},{"key":"BFsrep31894_CR32","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.1084\/jem.20100745","volume":"207","author":"S Kusy","year":"2010","unstructured":"Kusy, S. et al. NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia. J Exp Med 207, 2141\u201356 (2010).","journal-title":"J Exp Med"},{"key":"BFsrep31894_CR33","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/emboj.2010.342","volume":"30","author":"CG Palii","year":"2011","unstructured":"Palii, C. G. et al. Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages. EMBO J 30, 494\u2013509 (2011).","journal-title":"EMBO J"},{"key":"BFsrep31894_CR34","doi-asserted-by":"publisher","first-page":"7079","DOI":"10.1182\/blood-2010-12-317990","volume":"117","author":"JA Thoms","year":"2011","unstructured":"Thoms, J. A. et al. ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer. Blood 117, 7079\u201389 (2011).","journal-title":"Blood"},{"key":"BFsrep31894_CR35","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.ccr.2012.06.007","volume":"22","author":"T Sanda","year":"2012","unstructured":"Sanda, T. et al. Core Transcriptional Regulatory Circuit Controlled by the TAL1 Complex in Human T Cell Acute Lymphoblastic Leukemia. Cancer Cell 22, 209\u2013221 (2012).","journal-title":"Cancer Cell"},{"key":"BFsrep31894_CR36","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.1002\/stem.2028","volume":"33","author":"A Benyoucef","year":"2015","unstructured":"Benyoucef, A. et al. The SCL\/TAL1 Transcription Factor Represses the Stress Protein DDiT4\/REDD1 in Human Hematopoietic Stem\/Progenitor Cells. Stem Cells 33, 2268\u201379 (2015).","journal-title":"Stem Cells"},{"key":"BFsrep31894_CR37","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1038\/leu.2013.63","volume":"27","author":"NC Correia","year":"2013","unstructured":"Correia, N. C. et al. Novel TAL1 targets beyond protein-coding genes: identification of TAL1-regulated microRNAs in T-cell acute lymphoblastic leukemia. Leukemia 27, 1603\u20136 (2013).","journal-title":"Leukemia"},{"key":"BFsrep31894_CR38","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1084\/jem.20122516","volume":"210","author":"MR Mansour","year":"2013","unstructured":"Mansour, M. R. et al. The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia. J Exp Med 210, 1545\u201357 (2013).","journal-title":"J Exp Med"},{"key":"BFsrep31894_CR39","doi-asserted-by":"crossref","unstructured":"Al-Khalaf, H. H. & Aboussekhra, A. MicroRNA-141 and MicroRNA-146b-5p Inhibit the pro-Metastatic Mesenchymal Characteristics through the RNA Binding Protein AUF1 Targeting the Transcription Factor ZEB1 and the Protein Kinase AKT. J Biol Chem (2014).","DOI":"10.1074\/jbc.M114.593004"},{"key":"BFsrep31894_CR40","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1158\/0008-5472.CAN-08-3559","volume":"69","author":"DR Hurst","year":"2009","unstructured":"Hurst, D. R. et al. Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis. Cancer Res 69, 1279\u201383 (2009).","journal-title":"Cancer Res"},{"key":"BFsrep31894_CR41","doi-asserted-by":"publisher","first-page":"ra11","DOI":"10.1126\/scisignal.2004497","volume":"7","author":"M Xiang","year":"2014","unstructured":"Xiang, M. et al. STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-kappaB to IL-6 signaling axis and STAT3-driven cancer phenotypes. Sci Signal 7, ra11 (2014).","journal-title":"Sci Signal"},{"key":"BFsrep31894_CR42","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.brainres.2009.02.037","volume":"1269","author":"H Xia","year":"2009","unstructured":"Xia, H. et al. microRNA-146b inhibits glioma cell migration and invasion by targeting MMPs. Brain Res 1269, 158\u201365 (2009).","journal-title":"Brain Res"},{"key":"BFsrep31894_CR43","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.3109\/07357907.2010.512596","volume":"28","author":"M Katakowski","year":"2010","unstructured":"Katakowski, M. et al. MiR-146b-5p suppresses EGFR expression and reduces in vitro migration and invasion of glioma. Cancer Invest 28, 1024\u201330 (2010).","journal-title":"Cancer Invest"},{"key":"BFsrep31894_CR44","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s11596-011-0481-5","volume":"31","author":"F Lin","year":"2011","unstructured":"Lin, F. et al. Inhibitory effects of miR-146b-5p on cell migration and invasion of pancreatic cancer by targeting MMP16. J Huazhong Univ Sci Technolog Med Sci 31, 509\u201314 (2011).","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"key":"BFsrep31894_CR45","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1016\/j.humpath.2014.04.002","volume":"45","author":"PY Wu","year":"2014","unstructured":"Wu, P. Y., Zhang, X. D., Zhu, J., Guo, X. Y. & Wang, J. F. Low expression of microRNA-146b-5p and microRNA-320d predicts poor outcome of large B-cell lymphoma treated with cyclophosphamide, doxorubicin, vincristine, and prednisone. Hum Pathol 45, 1664\u201373 (2014).","journal-title":"Hum Pathol"},{"key":"BFsrep31894_CR46","doi-asserted-by":"publisher","first-page":"4089","DOI":"10.1182\/blood-2013-11-539411","volume":"123","author":"ML Burger","year":"2014","unstructured":"Burger, M. L., Xue, L., Sun, Y., Kang, C. & Winoto, A. Premalignant PTEN-deficient thymocytes activate microRNAs miR-146a and miR-146b as a cellular defense against malignant transformation. Blood 123, 4089\u2013100 (2014).","journal-title":"Blood"},{"key":"BFsrep31894_CR47","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1084\/jem.20110105","volume":"208","author":"E Clappier","year":"2011","unstructured":"Clappier, E. et al. Clonal selection in xenografted human T-cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse. J Exp Med 208, 653\u201361 (2011).","journal-title":"J Exp Med"},{"key":"BFsrep31894_CR48","doi-asserted-by":"crossref","unstructured":"Mets, E. et al. MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia. Leukemia (2014).","DOI":"10.1038\/leu.2014.276"},{"key":"BFsrep31894_CR49","doi-asserted-by":"publisher","first-page":"7053","DOI":"10.1182\/blood-2010-12-326629","volume":"117","author":"M Ghisi","year":"2011","unstructured":"Ghisi, M. et al. Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150. Blood 117, 7053\u201362 (2011).","journal-title":"Blood"},{"key":"BFsrep31894_CR50","doi-asserted-by":"publisher","first-page":"e22379","DOI":"10.1371\/journal.pone.0022379","volume":"6","author":"SK Patnaik","year":"2011","unstructured":"Patnaik, S. K., Kannisto, E., Mallick, R. & Yendamuri, S. Overexpression of the lung cancer-prognostic miR-146b microRNAs has a minimal and negative effect on the malignant phenotype of A549 lung cancer cells. PLos One 6, e22379 (2011).","journal-title":"PLos One"},{"key":"BFsrep31894_CR51","doi-asserted-by":"publisher","first-page":"4780","DOI":"10.1158\/0008-5472.CAN-10-3606","volume":"71","author":"A Silva","year":"2011","unstructured":"Silva, A. et al. IL-7 contributes to the progression of human T-cell acute lymphoblastic leukemias. Cancer Res 71, 4780\u20139 (2011).","journal-title":"Cancer Res"},{"key":"BFsrep31894_CR52","doi-asserted-by":"publisher","first-page":"W478","DOI":"10.1093\/nar\/gks402","volume":"40","author":"D Tabas-Madrid","year":"2012","unstructured":"Tabas-Madrid, D., Nogales-Cadenas, R. & Pascual-Montano, A. GeneCodis3: a non-redundant and modular enrichment analysis tool for functional genomics. Nucleic Acids Res 40, W478\u201383 (2012).","journal-title":"Nucleic Acids Res"},{"key":"BFsrep31894_CR53","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"W Huang da","year":"2009","unstructured":"Huang da, W., Sherman, B. T. & Lempicki, R. A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4, 44\u201357 (2009).","journal-title":"Nat Protoc"},{"key":"BFsrep31894_CR54","first-page":"737","volume":"19","author":"RK Kutty","year":"2013","unstructured":"Kutty, R. K. et al. Differential regulation of microRNA-146a and microRNA-146b-5p in human retinal pigment epithelial cells by interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma. Mol Vis 19, 737\u201350 (2013).","journal-title":"Mol Vis"},{"key":"BFsrep31894_CR55","doi-asserted-by":"publisher","first-page":"2831","DOI":"10.1074\/jbc.M114.591420","volume":"290","author":"H Park","year":"2015","unstructured":"Park, H., Huang, X., Lu, C., Cairo, M. S. & Zhou, X. MicroRNA-146a and microRNA-146b regulate human dendritic cell apoptosis and cytokine production by targeting TRAF6 and IRAK1 proteins. J Biol Chem 290, 2831\u201341 (2015).","journal-title":"J Biol Chem"},{"key":"BFsrep31894_CR56","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1182\/blood-2005-06-2530","volume":"107","author":"R Fragoso","year":"2006","unstructured":"Fragoso, R. et al. VEGFR-1 (FLT-1) activation modulates acute lymphoblastic leukemia localization and survival within the bone marrow, determining the onset of extramedullary disease. Blood 107, 1608\u201316 (2006).","journal-title":"Blood"},{"key":"BFsrep31894_CR57","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.ccell.2015.05.003","volume":"27","author":"D Passaro","year":"2015","unstructured":"Passaro, D. et al. CXCR4 Is Required for Leukemia-Initiating Cell Activity in T Cell Acute Lymphoblastic Leukemia. Cancer Cell 27, 769\u201379 (2015).","journal-title":"Cancer Cell"},{"key":"BFsrep31894_CR58","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.ccell.2015.05.002","volume":"27","author":"LA Pitt","year":"2015","unstructured":"Pitt, L. A. et al. CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance. Cancer Cell 27, 755\u201368 (2015).","journal-title":"Cancer Cell"},{"key":"BFsrep31894_CR59","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.canlet.2013.02.019","volume":"335","author":"M Katakowski","year":"2013","unstructured":"Katakowski, M. et al. Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth. Cancer Lett 335, 201\u20134 (2013).","journal-title":"Cancer Lett"},{"key":"BFsrep31894_CR60","doi-asserted-by":"publisher","first-page":"4977","DOI":"10.1182\/blood-2013-01-480079","volume":"121","author":"S Grasedieck","year":"2013","unstructured":"Grasedieck, S. et al. Circulating microRNAs in hematological diseases: principles, challenges, and perspectives. Blood 121, 4977\u20134984 (2013).","journal-title":"Blood"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep31894.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep31894","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep31894.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T06:10:29Z","timestamp":1672899029000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep31894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,23]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,8,31]]}},"alternative-id":["BFsrep31894"],"URL":"https:\/\/doi.org\/10.1038\/srep31894","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,23]]},"assertion":[{"value":"22 April 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"31894"}}