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Although highly conserved among higher eukaryotes, the mitotic function of this enzyme is still poorly understood. Naa50\/San was originally proposed to be required for centromeric sister chromatid cohesion in <jats:italic>Drosophila<\/jats:italic> and human cells, yet, more recently, it was also suggested to be a negative regulator of microtubule polymerization through internal acetylation of beta Tubulin. We used genetic and biochemical approaches to clarify the function of Naa50\/San during development. Our work suggests that Naa50\/San is required during tissue proliferation for the correct interaction between the cohesin subunits Scc1 and Smc3. Our results also suggest a working model where Naa50\/San N-terminally acetylates the nascent Scc1 polypeptide, and that this co-translational modification is subsequently required for the establishment and\/or maintenance of sister chromatid cohesion.<\/jats:p>","DOI":"10.1038\/srep39118","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T10:54:06Z","timestamp":1482231246000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Naa50\/San-dependent N-terminal acetylation of Scc1 is potentially important for sister chromatid cohesion"],"prefix":"10.1038","volume":"6","author":[{"given":"Ana Luisa","family":"Ribeiro","sequence":"first","affiliation":[]},{"given":"Rui D.","family":"Silva","sequence":"additional","affiliation":[]},{"given":"H\u00e5vard","family":"Foyn","sequence":"additional","affiliation":[]},{"given":"Margarida N.","family":"Tiago","sequence":"additional","affiliation":[]},{"given":"Om Singh","family":"Rathore","sequence":"additional","affiliation":[]},{"given":"Thomas","family":"Arnesen","sequence":"additional","affiliation":[]},{"given":"Rui Gon\u00e7alo","family":"Martinho","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2016,12,20]]},"reference":[{"key":"BFsrep39118_CR1","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.1002\/pmic.201400619","volume":"15","author":"S Varland","year":"2015","unstructured":"Varland, S., Osberg, C. & Arnesen, T. 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