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The increased number of multidrug-resistant <jats:italic>M. morganii<\/jats:italic> isolates motivates the search for alternative and effective antibacterials. We have isolated two novel obligatorily lytic <jats:italic>M. morganii<\/jats:italic> bacteriophages (vB_MmoM_MP1, vB_MmoP_MP2) and characterized them with respect to specificity, morphology, genome organization and phylogenetic relationships. MP1\u2019s dsDNA genome consists of 163,095\u2009bp and encodes 271 proteins, exhibiting low DNA (&lt;40%) and protein (&lt;70%) homology to other members of the <jats:italic>Tevenvirinae<\/jats:italic>. Its unique property is a &gt;10\u2009kb chromosomal inversion that encompass the baseplate assembly and head outer capsid synthesis genes when compared to other T-even bacteriophages. MP2 has a dsDNA molecule with 39,394\u2009bp and encodes 55 proteins, presenting significant genomic (70%) and proteomic identity (86%) but only to <jats:italic>Morganella<\/jats:italic> bacteriophage MmP1. MP1 and MP2 are then novel members of <jats:italic>Tevenvirinae<\/jats:italic> and <jats:italic>Autographivirinae<\/jats:italic>, respectively, but differ significantly from other tailed bacteriophages of these subfamilies to warrant proposing new genera. Both bacteriophages together could propagate in 23 of 27\u2009<jats:italic>M. morganii<\/jats:italic> clinical isolates of different origin and antibiotic resistance profiles, making them suitable for further studies on a development of bacteriophage cocktail for potential therapeutic applications.<\/jats:p>","DOI":"10.1038\/srep46157","type":"journal-article","created":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T09:57:11Z","timestamp":1491559031000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Characterization and genomic analyses of two newly isolated Morganella phages define distant members among Tevenvirinae and Autographivirinae subfamilies"],"prefix":"10.1038","volume":"7","author":[{"given":"Hugo","family":"Oliveira","sequence":"first","affiliation":[]},{"given":"Gra\u00e7a","family":"Pinto","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Jean-Paul","family":"Noben","sequence":"additional","affiliation":[]},{"given":"Hanne","family":"Hendrix","sequence":"additional","affiliation":[]},{"given":"Rob","family":"Lavigne","sequence":"additional","affiliation":[]},{"given":"Ma\u0142gorzata","family":"\u0141obocka","sequence":"additional","affiliation":[]},{"given":"Andrew M.","family":"Kropinski","sequence":"additional","affiliation":[]},{"given":"Joana","family":"Azeredo","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2017,4,7]]},"reference":[{"key":"BFsrep46157_CR1","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1146\/annurev.micro.55.1.437","volume":"55","author":"WC Summers","year":"2001","unstructured":"Summers, W. 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