{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:48:08Z","timestamp":1761540488186,"version":"3.30.2"},"reference-count":66,"publisher":"Royal Society of Chemistry (RSC)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Analyst"],"DOI":"10.1039\/an996210065r","type":"journal-article","created":{"date-parts":[[2004,3,25]],"date-time":"2004-03-25T13:38:47Z","timestamp":1080221927000},"page":"65R-76R","source":"Crossref","is-referenced-by-count":70,"title":["Tutorial review. Future prospects for the analysis of complex biological systems using micro-column liquid chromatography\u2013electrospray tandem mass spectrometry"],"prefix":"10.1039","volume":"121","author":[{"given":"John R.","family":"Yates","sequence":"first","affiliation":[]},{"given":"Ashley L.","family":"McCormack","sequence":"additional","affiliation":[]},{"given":"Andrew J.","family":"Link","sequence":"additional","affiliation":[]},{"given":"David","family":"Schieltz","sequence":"additional","affiliation":[]},{"given":"Jimmy","family":"Eng","sequence":"additional","affiliation":[]},{"given":"Lara","family":"Hays","sequence":"additional","affiliation":[]}],"member":"292","published-online":{"date-parts":[[1996]]},"reference":[{"key":"AN996210065R-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1126\/science.1925562","volume":"254","author":"Hunkapiller","year":"1991","journal-title":"Science"},{"key":"AN996210065R-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.1073\/pnas.90.10.4338","volume":"90","author":"Olson","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"AN996210065R-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1126\/science.7997873","volume":"266","author":"Marshall","year":"1994","journal-title":"Science"},{"key":"AN996210065R-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1126\/science.7939640","volume":"266","author":"Marshall","year":"1994","journal-title":"Science"},{"key":"AN996210065R-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1126\/science.2047873","volume":"252","author":"Adams","year":"1991","journal-title":"Science"},{"issue":"suppl., 3\u20131743","key":"AN996210065R-(cit6)\/*[position()=1]","volume":"377","author":"Adams et al.,","year":"1995","journal-title":"Nature (London)"},{"key":"AN996210065R-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1126\/science.7542800","volume":"269","author":"Fleischmann","year":"1995","journal-title":"Science"},{"key":"AN996210065R-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1126\/science.270.5235.397","volume":"270","author":"Fraser","year":"1995","journal-title":"Science"},{"key":"AN996210065R-(cit9)\/*[position()=1]","first-page":"265","volume":"67","author":"Krishna","year":"1993","journal-title":"Adv. Enzymol. Relat. Areas Mol. Biol."},{"key":"AN996210065R-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/0092-8674(87)90509-5","volume":"50","author":"Hunter","year":"1987","journal-title":"Cell."},{"key":"AN996210065R-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1073\/pnas.84.3.620","volume":"84","author":"Hunt","year":"1986","journal-title":"Proc. Natl. Acad. Sci., USA"},{"key":"AN996210065R-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1021\/j100313a058","volume":"92","author":"Wong","year":"1988","journal-title":"J. Phys. Chem."},{"key":"AN996210065R-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1126\/science.2675315","volume":"246","author":"Fenn","year":"1989","journal-title":"Science"},{"key":"AN996210065R-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/mas.1280090103","volume":"9","author":"Fenn","year":"1990","journal-title":"Mass Spectrom. Rev."},{"key":"AN996210065R-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1021\/ac00208a002","volume":"62","author":"Smith","year":"1990","journal-title":"Anal. Chem."},{"key":"AN996210065R-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/mas.1280100504","volume":"10","author":"Smith","year":"1991","journal-title":"Mass Spectrom. Rev."},{"key":"AN996210065R-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1021\/ac00013a003","volume":"63","author":"Covey","year":"1991","journal-title":"Anal. Chem."},{"key":"AN996210065R-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0168-1176(91)85052-N","volume":"111","author":"Griffin","year":"1991","journal-title":"Int. J. Mass Spectrom. Ion Processes"},{"key":"AN996210065R-(cit19)\/*[position()=1]","volume-title":"Proceedings of the 39th ASMS Conference on Mass Spectrometry and Allied Topics","author":"Griffin","year":"1991","unstructured":"P. R. Griffin , L. E.Hood, and J. R.Yates, III, Proceedings of the 39th ASMS Conference on Mass Spectrometry and Allied Topics, Nashville, TN, 1991, pp. 1157\u20131158."},{"key":"AN996210065R-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/elps.1150140170","volume":"14","author":"Wahl","year":"1993","journal-title":"Electrophoresis"},{"key":"AN996210065R-(cit21)\/*[position()=1]","volume-title":"Techniques in Protein Chemistry III","author":"Griffin","year":"1992","unstructured":"P. R. Griffin , K.Furer-Jonshur, L. E.Hood, J. R.Yates, III, J.Schwartz, and I.Jardine, Techniques in Protein Chemistry III, ed. Angeletti, R. A., Academic Press, New York, 1992, pp. 467\u2013476."},{"key":"AN996210065R-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/rcm.1290071111","volume":"7","author":"Gale","year":"1993","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"AN996210065R-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/1044-0305(94)85001-1","volume":"5","author":"Emmett","year":"1994","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"AN996210065R-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0168-1176(94)04024-9","volume":"136","author":"Wilm","year":"1994","journal-title":"Int. J. Mass Spectrom. Ion Processes"},{"key":"AN996210065R-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1021\/ac00278a088","volume":"56","author":"Shelley","year":"1984","journal-title":"Anal. Chem."},{"key":"AN996210065R-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1021\/ac00185a016","volume":"61","author":"Kennedy","year":"1989","journal-title":"Anal. Chem."},{"key":"AN996210065R-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1126\/science.7513441","volume":"264","author":"Cox","year":"1994","journal-title":"Science"},{"key":"AN996210065R-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/1044-0305(90)85052-N","volume":"1","author":"Huang","year":"1990","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"AN996210065R-(cit29)\/*[position()=1]","volume-title":"Proceedings of the 39th ASMS Conference on Mass Spectrometry and Allied Topics","author":"Stahl","year":"1992","unstructured":"D. C. Stahl , P. A.Martino, K. M.Swiderek, M. T.Davis, and T. D.Lee, Proceedings of the 39th ASMS Conference on Mass Spectrometry and Allied Topics, Washington, DC, 1992, pp. 1801\u20131802."},{"key":"AN996210065R-(cit30)\/*[position()=1]","volume-title":"Identification of Individual Proteins in Mixtures using Micro-Column HPLC Tandem Mass Spectrometry and Automated Database Analysis","author":"Yates, III","year":"1994","unstructured":"J. R. Yates, III , A. L.McCormack, and J.Eng, Identification of Individual Proteins in Mixtures using Micro-Column HPLC Tandem Mass Spectrometry and Automated Database Analysis, presented at the Methods in Protein Structure Analysis Meeting, Snowbird, UT, September 9\u201313, 1994."},{"key":"AN996210065R-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1021\/ac00104a020","volume":"67","author":"Yates III","year":"1995","journal-title":"Anal. Chem."},{"key":"AN996210065R-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/bms.1200191103","volume":"19","author":"Lee","year":"1990","journal-title":"Biomed. Environ. Mass Spectrom."},{"key":"AN996210065R-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/1044-0305(91)80012-V","volume":"2","author":"Papayannopoulos","year":"1991","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"AN996210065R-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1042\/bst0190957","volume":"19","author":"Watkins","year":"1991","journal-title":"Biochem. Soc. Trans."},{"key":"AN996210065R-(cit35)\/*[position()=1]","volume-title":"Techniques in Protein Chemistry","author":"Hunt","year":"1989","unstructured":"D. F. Hunt , P. R.Griffin, J. R.Yates, III, J.Shabanowitz, J. W.Fox, and L. K.Beggerly, in Techniques in Protein Chemistry, ed. Hugli, T. E., Academic Press, San Diego, CA, 1989, pp. 580\u2013588."},{"key":"AN996210065R-(cit36)\/*[position()=1]","volume-title":"Techniques in Protein Chemistry II","author":"Hunt","year":"1991","unstructured":"D. F. Hunt , J. E.Alexander, A. L.McCormack, P. A.Martino, H.Michel, and J.Shabanowitz, in Techniques in Protein Chemistry II, ed. Villafranca, J. J., Academic Press, San Diego, CA, 1991, pp. 455\u2013465."},{"key":"AN996210065R-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1101\/SQB.1993.058.01.043","volume":"58","author":"Waterston","year":"1993","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"AN996210065R-(cit38)\/*[position()=1]","first-page":"221","volume":"2","author":"Olson","year":"1992","journal-title":"Curr. Opinion Biol."},{"key":"AN996210065R-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5795","DOI":"10.1002\/j.1460-2075.1994.tb06923.x","volume":"13","author":"Feldman","year":"1994","journal-title":"EMBO J."},{"key":"AN996210065R-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/369371a0","volume":"369","author":"Dujon","year":"1994","journal-title":"Nature, (London)"},{"key":"AN996210065R-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/357038a0","volume":"357","author":"Oliver","year":"1992","journal-title":"Nature (London)"},{"key":"AN996210065R-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1093\/nar\/22.13.2576","volume":"22","author":"Sofia","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"AN996210065R-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5463","DOI":"10.1073\/pnas.74.12.5463","volume":"74","author":"Sanger","year":"1977","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"AN996210065R-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1073\/pnas.74.2.560","volume":"74","author":"Maxam","year":"1977","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"AN996210065R-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0006-291X(83)91575-9","volume":"117","author":"Morris","year":"1983","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"AN996210065R-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1073\/pnas.81.7.1956","volume":"81","author":"Gibson","year":"1984","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"AN996210065R-(cit47)\/*[position()=1]","first-page":"1","volume":"4","author":"Yates III","year":"1988","journal-title":"Intelligenetics"},{"key":"AN996210065R-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1006\/abio.1993.1514","volume":"214","author":"Yates III","year":"1993","journal-title":"Anal. Biochem."},{"key":"AN996210065R-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.1073\/pnas.90.11.5011","volume":"90","author":"Henzel","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"AN996210065R-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1006\/bbrc.1993.2009","volume":"195","author":"James","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"AN996210065R-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0960-9822(93)90195-T","volume":"3","author":"Pappin","year":"1993","journal-title":"Curr. Biol."},{"key":"AN996210065R-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/bms.1200220605","volume":"22","author":"Mann","year":"1993","journal-title":"Biol. Mass Spectrom."},{"key":"AN996210065R-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/1044-0305(94)80016-2","volume":"5","author":"Eng","year":"1994","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"AN996210065R-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1021\/ac00114a016","volume":"67","author":"Yates III","year":"1995","journal-title":"Anal. Chem."},{"key":"AN996210065R-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/bms.1200130709","volume":"13","author":"Ishikawa","year":"1986","journal-title":"Biomed. Environ. Mass Spectrom."},{"key":"AN996210065R-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/bms.1200181102","volume":"18","author":"Johnson","year":"1989","journal-title":"Biomed. Environ. Mass Spectrom."},{"key":"AN996210065R-(cit57)\/*[position()=1]","first-page":"477","volume-title":"Techniques in Protein Chemistry II","author":"Yates, III","year":"1990","unstructured":"J. R. Yates, III , J.Zhou, P. R.Griffin, and L. E.Hood, in Techniques in Protein Chemistry II, ed. Villafranca, J., Academic Press, New York, 1990, p. 477."},{"key":"AN996210065R-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/1044-0305(92)87060-C","volume":"3","author":"Hines","year":"1992","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"AN996210065R-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1126\/science.1546328","volume":"255","author":"Hunt","year":"1992","journal-title":"Science"},{"key":"AN996210065R-(cit60)\/*[position()=1]","volume-title":"Cell Biology: A Laboratory Handbook","author":"Yates, III","year":"1994","unstructured":"J. R. Yates, III , A. L.McCormack, J. B.Hayden, and M. P.Davey, in Cell Biology: A Laboratory Handbook, ed. Celis, J. E., Academic Press, San Diego, CA, 1994, pp. 380\u2013388."},{"key":"AN996210065R-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/343071a0","volume":"343","author":"Mellins","year":"1990","journal-title":"Nature (London)"},{"key":"AN996210065R-(cit62)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4468","DOI":"10.4049\/jimmunol.153.10.4468","volume":"153","author":"Monji","year":"1994","journal-title":"J. Immunol."},{"key":"AN996210065R-(cit63)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1126\/science.1465617","volume":"258","author":"Sette","year":"1992","journal-title":"Science"},{"key":"AN996210065R-(cit64)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/360474a0","volume":"360","author":"Riberdy","year":"1992","journal-title":"Nature (London)"},{"key":"AN996210065R-(cit65)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/1074-7613(94)90048-5","volume":"1","author":"Rudensky","year":"1994","journal-title":"Immunity"},{"key":"AN996210065R-(cit66)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1073\/pnas.91.6.2171","volume":"91","author":"Maric","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["The Analyst"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/1996\/AN\/AN996210065R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T17:35:12Z","timestamp":1734284112000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=AN996210065R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996]]},"references-count":66,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1996]]}},"URL":"https:\/\/doi.org\/10.1039\/an996210065r","relation":{},"ISSN":["0003-2654","1364-5528"],"issn-type":[{"type":"print","value":"0003-2654"},{"type":"electronic","value":"1364-5528"}],"subject":[],"published":{"date-parts":[[1996]]}}}