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Of particular interest to us is the well known ribozyme from Tetrahymena thermophila capable of catalyzing RNA splicing in eukaryotic systems, chiefly because of its potential use as a gene therapy agent. In this article we review the progress made towards visualizing the RNA splicing mediated by the Tetrahymena ribozyme in single living mammalian cells with the \u03b2-lactamase reporter system and highlight the development made in imaging RNA splicing with the luciferase reporter system in living animals.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/b617574k","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T10:27:51Z","timestamp":1172053671000},"page":"301-307","source":"Crossref","is-referenced-by-count":4,"title":["Visualizing RNA splicing\n                    <i>in vivo<\/i>"],"prefix":"10.1093","volume":"3","author":[{"given":"Gayatri","family":"Gowrishankar","sequence":"first","affiliation":[{"name":"Molecular Imaging Program at Stanford, Department of Radiology & Bio-X Program, Cancer Biology Program, Stanford University School of Medicine a , 1201 Welch Road, Stanford, California 94305-5484, USA jrao@stanford.edu (+1) 650-736-7925"}]},{"given":"Jianghong","family":"Rao","sequence":"additional","affiliation":[{"name":"Molecular Imaging Program at Stanford, Department of Radiology & Bio-X Program, Cancer Biology Program, Stanford University School of Medicine a , 1201 Welch Road, Stanford, California 94305-5484, USA jrao@stanford.edu (+1) 650-736-7925"}]}],"member":"286","published-online":{"date-parts":[[2007,2,21]]},"reference":[{"key":"2026010702345124500_cit1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1126\/science.2678472","volume":"246","author":"Waldrop","year":"1989","journal-title":"Science"},{"key":"2026010702345124500_cit2","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1146\/annurev.bi.59.070190.002551","volume":"59","author":"Cech","year":"1990","journal-title":"Annu. 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