{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:37:32Z","timestamp":1790199452074,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Photochem Photobiol Sci"],"published-print":{"date-parts":[[2005,8]]},"DOI":"10.1039\/b504068j","type":"journal-article","created":{"date-parts":[[2005,7,8]],"date-time":"2005-07-08T13:55:32Z","timestamp":1120830932000},"page":"577-582","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Cyclobutane pyrimidine dimer formation is a molecular trigger for solar-simulated ultraviolet radiation-induced suppression of memory immunity in humans"],"prefix":"10.1007","volume":"4","author":[{"given":"Johanna M.","family":"Kuchel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross St. C.","family":"Barnetson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary M.","family":"Halliday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,8,1]]},"reference":[{"key":"40803_CR1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/S1011-1344(01)00198-1","volume":"63","author":"B K Armstrong","year":"2001","unstructured":"B. K. Armstrong, A. Kricker The epidemiology of UV induced skin cancer J. Photochem. Photobiol. B: Biol. 2001 63 8\u201318","journal-title":"J. Photochem. Photobiol. B: Biol."},{"key":"40803_CR2","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1046\/j.1523-1747.1999.00610.x","volume":"112","author":"D L Damian","year":"1999","unstructured":"D. L. Damian, G. M. Halliday, R. S. Barnetson Low-dose UVA and UVB have different time courses for suppression of contact hypersensitivity to a recall antigen in humans J. Invest. Dermatol. 1999 112 939\u2013944","journal-title":"J. Invest. Dermatol."},{"key":"40803_CR3","doi-asserted-by":"publisher","first-page":"4954","DOI":"10.1073\/pnas.0401141101","volume":"101","author":"N S Agar","year":"2004","unstructured":"N. S. Agar, G. M. Halliday, R. S. Barnetson, H. N. Ananthaswamy, M. Wheeler, A. M. Jones The basal layer in human squamous tumors harbors more UVA than UVB fingerprint mutations: A role for UVA in human skin carcinogenesis Proc. Natl. Acad. Sci. USA 2004 101 4954\u20134959","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"40803_CR4","first-page":"136","volume":"1","author":"D E Brash","year":"1996","unstructured":"D. E. Brash, A. Ziegler, A. S. Jonason, J. A. Simon, S. Kunala, D. J. Leffell Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion J. Invest. Dermatol. Symp. Proc. 1996 1 136\u201342","journal-title":"J. Invest. Dermatol. Symp. Proc."},{"key":"40803_CR5","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.taap.2003.08.019","volume":"195","author":"Y Matsumura","year":"2004","unstructured":"Y. Matsumura, H. N. Ananthaswamy Toxic effects of ultraviolet radiation on the skin Toxicol. Appl. Pharmacol 2004 195 298\u2013308","journal-title":"Toxicol. Appl. Pharmacol"},{"key":"40803_CR6","first-page":"4227","volume":"52","author":"D Yarosh","year":"1992","unstructured":"D. Yarosh, L. G. Alas, V. Yee, A. Oberyszyn, J. T. Kibitel, D. Mitchell, R. Rosenstein, A. Spinowitz, M. Citron Pyrimidine dimer removal enhanced by DNA repair liposomes reduces the incidence of UV skin cancer in mice Cancer Res. 1992 52 4227\u201331","journal-title":"Cancer Res."},{"key":"40803_CR7","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1034\/j.1600-0781.2001.170501.x","volume":"17","author":"D B Yarosh","year":"2001","unstructured":"D. B. Yarosh Liposomes in investigative dermatology [Review] Photodermatol., Photoimmunol. Photomed. 2001 17 203\u2013212","journal-title":"Photodermatol., Photoimmunol. Photomed."},{"key":"40803_CR8","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1084\/jem.183.4.1491","volume":"183","author":"A A Vink","year":"1996","unstructured":"A. A. Vink, F. M. Strickland, C. Bucana, P. A. Cox, L. Roza, D. B. Yarosh, M. L. Kripke Localization of DNA damage and its role in altered antigen-presenting cell function in ultraviolet-irradiated mice J. Exp. Med. 1996 183 1491\u20131500","journal-title":"J. Exp. Med."},{"key":"40803_CR9","doi-asserted-by":"publisher","first-page":"7516","DOI":"10.1073\/pnas.89.16.7516","volume":"89","author":"M L Kripke","year":"1992","unstructured":"M. L. Kripke, P. A. Cox, L. G. Alas, D. B. Yarosh Pyrimidine dimers in DNA initiate systemic immunosuppression in UV-irradiated mice Proc. Natl. Acad. Sci. USA 1992 89 7516\u20137520","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"40803_CR10","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1111\/1523-1747.ep12612828","volume":"104","author":"P Wolf","year":"1995","unstructured":"P. Wolf, P. Cox, D. B. Yarosh, M. L. Kripke Sunscreens and T4N5 liposomes differ in their ability to protect against ultraviolet-induced sunburn cell formation, alterations of dendritic epidermal cells, and local suppression of contact hypersensitivity J Invest. Dermatol. 1995 104 287\u2013292","journal-title":"J Invest. Dermatol."},{"key":"40803_CR11","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/j.1751-1097.1996.tb03050.x","volume":"63","author":"A A Vink","year":"1996","unstructured":"A. A. Vink, D. B. Yarosh, M. L. Kripke Chromophore For UV-induced immunosuppression-DNA Photochem. Photobiol. 1996 63 383\u2013386","journal-title":"Photochem. Photobiol."},{"key":"40803_CR12","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1034\/j.1600-0781.2002.180307.x","volume":"18","author":"T Schwarz","year":"2002","unstructured":"T. Schwarz Photoimmunosuppression Photodermatol., Photoimmunol. Photomed. 2002 18 141\u2013145","journal-title":"Photodermatol., Photoimmunol. Photomed."},{"key":"40803_CR13","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/S0140-6736(00)04214-8","volume":"357","author":"D Yarosh","year":"2001","unstructured":"D. Yarosh, J. Klein, A. O\u2019Connor, J. Hawk, E. Rafal, P. Wolf Effect of topically applied T4 endonuclease V in liposomes on skin cancer in xeroderma pigmentosum: a randomised study Lancet. 2001 357 926\u2013929","journal-title":"Lancet."},{"key":"40803_CR14","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1111\/1523-1747.ep12319200","volume":"109","author":"D L Damian","year":"1997","unstructured":"D. L. Damian, G. M. Halliday, R. S. Barnetson Broad-spectrum sunscreens provide greater protection against ultraviolet-radiation-induced suppression of contact hypersensitivity to a recall antigen in humans J. Invest. Dermatol. 1997 109 146\u2013151","journal-title":"J. Invest. Dermatol."},{"key":"40803_CR15","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/S1046-2023(02)00208-6","volume":"28","author":"D L Damian","year":"2002","unstructured":"D. L. Damian, G. M. Halliday Measurement of ultraviolet radiation-induced suppression of recall contact and delayed-type hypersensitivity in humans Methods 2002 28 34\u201345","journal-title":"Methods"},{"key":"40803_CR16","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1046\/j.1523-1747.2003.12415.x","volume":"121","author":"J M Kuchel","year":"2003","unstructured":"J. M. Kuchel, R. S. Barnetson, G. M. Halliday Nitric oxide appears to be a mediator of solar-simulated ultraviolet radiation-induced immunosuppression in humans J. Invest. Dermatol. 2003 121 587\u2013593","journal-title":"J. Invest. Dermatol."},{"key":"40803_CR17","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1046\/j.1523-1747.2002.01773.x","volume":"118","author":"J M Kuchel","year":"2002","unstructured":"J. M. Kuchel, R. S. C. Barnetson, G. M. Halliday Ultraviolet A augments solar-simulated ultraviolet radiation-induced local suppression of recall responses in humans J. Invest. Dermatol. 2002 118 1032\u20131037","journal-title":"J. Invest. Dermatol."},{"key":"40803_CR18","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1111\/j.1365-2133.1994.tb08580.x","volume":"131","author":"A Patel","year":"1994","unstructured":"A. Patel, G. M. Halliday, B. E. Cooke, R. S. Barnetson Evidence that regression in keratoacanthoma is immunologically mediated: a comparison with squamous cell carcinoma Br. J. Dermatol. 1994 131 789\u201398","journal-title":"Br. J. Dermatol."},{"key":"40803_CR19","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1046\/j.1365-2133.1999.02898.x","volume":"140","author":"M S Duthie","year":"1999","unstructured":"M. S. Duthie, I. Kimber, M. Norval The effects of ultraviolet radiation on the human immune system [Review] Br. J. Dermatol. 1999 140 995\u20131009","journal-title":"Br. J. Dermatol."},{"key":"40803_CR20","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1046\/j.1523-1747.2002.01845.x","volume":"119","author":"D X Nghiem","year":"2002","unstructured":"D. X. Nghiem, N. Kazimi, D. L. Mitchell, A. A. Vink, H. N. Ananthaswamy, M. L. Kripke, S. E. Ullrich Mechanisms underlying the suppression of established immune responses by ultraviolet radiation J. Invest. Dermatol. 2002 119 600\u2013608","journal-title":"J. Invest. Dermatol."},{"key":"40803_CR21","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1073\/pnas.030528897","volume":"97","author":"H Stege","year":"2000","unstructured":"H. Stege, L. Roza, A. A. Vink, M. Grewe, T. Ruzicka, S. Grether-Beck, J. Krutmann Enzyme plus light therapy to repair DNA damage in ultraviolet-B-irradiated human skin Proc. Natl. Acad. Sci. USA 2000 97 1790\u20131795","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"40803_CR22","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/0167-5699(95)80148-0","volume":"16","author":"G Stingl","year":"1995","unstructured":"G. Stingl, P. R. Bergstresser Dendritic cells: A major story unfolds Immunol. Today 1995 16 330\u2013333","journal-title":"Immunol. Today"},{"key":"40803_CR23","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0027-5107(98)00186-9","volume":"422","author":"G W Dandie","year":"1998","unstructured":"G. W. Dandie, G. J. Clydesdale, I. Jacobs, H. K. Muller Effects of UV on the migration and function of epidermal antigen presenting cells Mutat. Res. 1998 422 147\u2013154","journal-title":"Mutat. Res."},{"key":"40803_CR24","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1046\/j.1440-1711.2001.00975.x","volume":"79","author":"G W Dandie","year":"2001","unstructured":"G. W. Dandie, G. J. Clydesdale, F. J. Radcliff, H. K. Muller Migration of Langerhans cells and gamma delta(+) dendritic cells from UV-B-irradiated sheep skin Immunol. Cell Biol. 2001 79 41\u201348","journal-title":"Immunol. Cell Biol."},{"key":"40803_CR25","first-page":"394","volume":"77","author":"A M Moodycliffe","year":"1992","unstructured":"A. M. Moodycliffe, I. Kimber, M. Norval The effect of ultraviolet-B irradiation and urocanic acid isomers on dendritic cell migration Immunology 1992 77 394\u2013399","journal-title":"Immunology"},{"key":"40803_CR26","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1111\/1523-1747.ep12606971","volume":"104","author":"Y Sontag","year":"1995","unstructured":"Y. Sontag, C. L. H. Guikers, A. A. Vink, F. R. Degruijl, H. Vanloveren, J. Garssen, L. Roza, M. L. Kripke, J. C. Vanderleun, W. A. Vanvloten Cells with UV-specific DNA damage are present in murine lymph nodes after in vivo UV irradiation J. Invest. Dermatol. 1995 104 734\u2013738","journal-title":"J. Invest. Dermatol."},{"key":"40803_CR27","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1111\/1523-1747.ep12395551","volume":"103","author":"D Yarosh","year":"1994","unstructured":"D. Yarosh, C. Bucana, P. Cox, L. Alas, J. Kibitel, M. Kripke Localization of liposomes containing a DNA repair enzyme in murine skin J. Invest. Dermatol. 1994 103 461\u2013468","journal-title":"J. Invest. Dermatol."},{"key":"40803_CR28","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/ncb717","volume":"4","author":"A Schwarz","year":"2002","unstructured":"A. Schwarz, S. Stander, M. Berneburg, M. Bohm, D. Kulms, H. van Steeg, K. Grosse-Heitmeyer, J. Krutmann, T. Schwarz Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair Nat. Cell Biol. 2002 4 26\u201331","journal-title":"Nat. Cell Biol."},{"key":"40803_CR29","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1084\/jem.20041212","volume":"201","author":"A Schwarz","year":"2005","unstructured":"A. Schwarz, A. Maeda, K. Kernebeck, H. van Steeg, S. Beissert, T. Schwarz Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair J. Exp. Med. 2005 201 173\u2013179","journal-title":"J. Exp. Med."},{"key":"40803_CR30","doi-asserted-by":"publisher","first-page":"8497","DOI":"10.1073\/pnas.89.18.8497","volume":"89","author":"K D Cooper","year":"1992","unstructured":"K. D. Cooper, L. Oberhelman, T. A. Hamilton, O. Baadsgaard, M. Terhune, G. Levee, T. Anderson, H. Koren UV exposure reduces immunization rates and promotes tolerance to epicutaneous antigens in humans-relationship to dose, CD1a-DR+ epidermal macrophage induction, and Langerhans cell depletion Proc. Natl. Acad. Sci. USA 1992 89 8497\u20138501","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"40803_CR31","doi-asserted-by":"crossref","first-page":"4915","DOI":"10.4049\/jimmunol.153.11.4915","volume":"153","author":"C Hammerberg","year":"1994","unstructured":"C. Hammerberg, N. Duraiswamy, K. D. Cooper Active induction of unresponsiveness (tolerance) to DNFB by in vivo ultraviolet-exposed epidermal cells is dependent upon infiltrating class II MHC(+) CD11b(bright) monocytic\/macrophagic cells J. Immunol. 1994 153 4915\u20134924","journal-title":"J. Immunol."},{"key":"40803_CR32","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1093\/carcin\/21.10.1801","volume":"21","author":"R Sluyter","year":"2000","unstructured":"R. Sluyter, G. M. Halliday Enhanced tumor growth in UV-irradiated skin is associated with an influx of inflammatory cells into the epidermis Carcinogenesis 2000 21 1801\u20131807","journal-title":"Carcinogenesis"},{"key":"40803_CR33","doi-asserted-by":"crossref","first-page":"5256","DOI":"10.4049\/jimmunol.153.11.5256","volume":"153","author":"K F Kang","year":"1994","unstructured":"K. F. Kang, C. Hammerberg, L. Meunier, K. D. Cooper CD11b(+) macrophages that infiltrate human epidermis after in vivo ultraviolet exposure potently produce IL-10 and represent the major secretory source of epidermal IL-10 protein J. Immunol. 1994 153 5256\u20135264","journal-title":"J. Immunol."},{"key":"40803_CR34","doi-asserted-by":"publisher","first-page":"10354","DOI":"10.1073\/pnas.93.19.10354","volume":"93","author":"C Nishigori","year":"1996","unstructured":"C. Nishigori, D. B. Yarosh, S. E. Ullrich, A. A. Vink, C. D. Bucana, L. Roza, M. L. Kripke Evidence that DNA damage triggers interleukin 10 cytokine production in UV-irradiated murine keratinocytes Proc. Natl. Acad. Sci. USA 1996 93 10354\u201310359","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Photochemical &amp; Photobiological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1039\/b504068j.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1039\/b504068j\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2005\/PP\/B504068J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1039\/b504068j.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T18:27:28Z","timestamp":1683138448000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1039\/b504068j"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["40803"],"URL":"https:\/\/doi.org\/10.1039\/b504068j","relation":{},"ISSN":["1474-905X","1474-9092"],"issn-type":[{"value":"1474-905X","type":"print"},{"value":"1474-9092","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8]]},"assertion":[{"value":"21 March 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2005","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2005","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}