{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:59:42Z","timestamp":1782943182007,"version":"3.54.5"},"reference-count":31,"publisher":"Royal Society of Chemistry (RSC)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Org. Biomol. Chem."],"DOI":"10.1039\/b614758e","type":"journal-article","created":{"date-parts":[[2006,11,22]],"date-time":"2006-11-22T11:29:17Z","timestamp":1164194957000},"page":"160-168","source":"Crossref","is-referenced-by-count":18,"title":["Exploring the chemistry of penicillin as a \u03b2-lactamase-dependent prodrug"],"prefix":"10.1039","volume":"5","author":[{"given":"Carol C.","family":"Ruddle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy P.","family":"Smyth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2007]]},"reference":[{"key":"B614758E-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.jmb.2006.01.003","volume":"357","author":"Murphy","year":"2006","journal-title":"J. Mol. Biol."},{"key":"B614758E-(cit2a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1128\/AAC.10.2.245","author":"O'Callaghan","year":"1976","journal-title":"Antimicrob. Agents Chemother."},{"key":"B614758E-(cit2b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1128\/AAC.10.2.249","author":"Greenwood","year":"1976","journal-title":"Antimicrob. Agents Chemother."},{"key":"B614758E-(cit2c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7879","DOI":"10.1016\/S0021-9258(19)57485-3","volume":"261","author":"Mobashery","year":"1986","journal-title":"J. Biol. Chem."},{"key":"B614758E-(cit2d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5878","DOI":"10.1021\/bi00392a045","volume":"26","author":"Mobashery","year":"1987","journal-title":"Biochemistry"},{"key":"B614758E-(cit2e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5699","DOI":"10.1016\/S0040-4020(00)00419-1","volume":"56","author":"Smyth","year":"2000","journal-title":"Tetrahedron"},{"key":"B614758E-(cit3a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1021\/jm00163a013","volume":"33","author":"Albrecht","year":"1990","journal-title":"J. Med. Chem."},{"key":"B614758E-(cit3b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1021\/jm00106a031","volume":"34","author":"Albrecht","year":"1991","journal-title":"J. Med. Chem."},{"key":"B614758E-(cit3c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1021\/jm00113a026","volume":"34","author":"Albrecht","year":"1991","journal-title":"J. Med. Chem."},{"key":"B614758E-(cit3d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1021\/jm00029a012","volume":"37","author":"Albrecht","year":"1994","journal-title":"J. Med. Chem."},{"key":"B614758E-(cit3e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"200","DOI":"10.7164\/antibiotics.44.200","volume":"44","author":"Demuth","year":"1991","journal-title":"J. Antibiot."},{"key":"B614758E-(cit3f)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/978-1-4615-4897-3_13","volume":"456","author":"Hershberger","year":"1998","journal-title":"Adv. Exp. Med. Biol."},{"key":"B614758E-(cit4)\/*[position()=2]","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1126\/science.283.5402.703","volume":"283","author":"Rosen","year":"1999","journal-title":"Science"},{"key":"B614758E-(cit5a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7600","DOI":"10.1021\/jo970737f","volume":"63","author":"Smyth","year":"1998","journal-title":"J. Org. Chem."},{"key":"B614758E-(cit5b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1021\/jo981993a","volume":"64","author":"Smyth","year":"1999","journal-title":"J. Org. Chem."},{"key":"B614758E-(cit5c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5699","DOI":"10.1016\/S0040-4020(00)00419-1","volume":"56","author":"Smyth","year":"2000","journal-title":"Tetrahedron"},{"key":"B614758E-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1039\/B409517K","author":"Ruddle","year":"2004","journal-title":"Chem. Commun."},{"key":"B614758E-(cit7a)\/*[position()=1]","volume-title":"Advances in Physical Organic Chemistry, vol. 17","author":"Kirby","year":"1980","unstructured":"A. J. Kirby , in Advances in Physical Organic Chemistry, vol. 17, ch. 3, 1980"},{"key":"B614758E-(cit7b)\/*[position()=1]","volume-title":"Advances in Physical Organic Chemistry, vol. 22","author":"Mandolini","year":"1986","unstructured":"L. Mandolini , in Advances in Physical Organic Chemistry, vol. 22, ch. 1, 1986"},{"key":"B614758E-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7965","DOI":"10.1021\/jo048970i","volume":"69","author":"Grant","year":"2004","journal-title":"J. Org. Chem."},{"key":"B614758E-(cit9a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/0960-894X(95)00249-S","volume":"5","author":"Buynak","year":"1995","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"B614758E-(cit9b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4945","DOI":"10.1016\/S0040-4039(98)00963-0","volume":"39","author":"Buynak","year":"1998","journal-title":"Tetrahedron Lett."},{"key":"B614758E-(cit9d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1021\/jm00006a022","volume":"38","author":"Buynak","year":"1995","journal-title":"J. Med. Chem."},{"key":"B614758E-(cit9e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0960-894X(00)00098-6","volume":"10","author":"Buynak","year":"2000","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"B614758E-(cit11a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"24","DOI":"10.7164\/antibiotics.35.24","volume":"35","author":"Tsuji","year":"1982","journal-title":"J. Antibiot."},{"key":"B614758E-(cit11b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"32","DOI":"10.7164\/antibiotics.35.32","volume":"35","author":"Kimura","year":"1982","journal-title":"J. Antibiot."},{"key":"B614758E-(cit11c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"38","DOI":"10.7164\/antibiotics.35.39","volume":"35","author":"Murakami","year":"1982","journal-title":"J. Antibiot."},{"key":"B614758E-(cit14)\/*[position()=2]","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1021\/jm970790w","volume":"41","author":"Maryanoff","year":"1998","journal-title":"J. Med. Chem."},{"key":"B614758E-(cit15a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1021\/ol049514j","volume":"6","author":"Ritter","year":"2004","journal-title":"Org. Lett."},{"key":"B614758E-(cit15b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5461","DOI":"10.1021\/jo0256538","volume":"67","author":"Barrero","year":"2002","journal-title":"J. Org. Chem."},{"key":"B614758E-(cit17)\/*[position()=2]","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1021\/jm00171a028","volume":"33","author":"Doherty, et al.","year":"1990","journal-title":"J. Med. Chem."}],"container-title":["Org. Biomol. Chem."],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2007\/OB\/B614758E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:28:17Z","timestamp":1782941297000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/5\/1\/160-168\/164914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1039\/b614758e","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}