{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T14:38:28Z","timestamp":1788359908998,"version":"build-2803163510"},"reference-count":42,"publisher":"Royal Society of Chemistry (RSC)","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Org. Biomol. Chem."],"published-print":{"date-parts":[[2008]]},"DOI":"10.1039\/b804907f","type":"journal-article","created":{"date-parts":[[2008,7,9]],"date-time":"2008-07-09T09:43:16Z","timestamp":1215596596000},"page":"3177","source":"Crossref","is-referenced-by-count":34,"title":["Design and synthesis of bioactive 1,2-annulated adamantane derivatives"],"prefix":"10.1039","volume":"6","author":[{"given":"Grigoris","family":"Zoidis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Tsotinis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Kolocouris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Radhika","family":"Prathalingam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieve","family":"Naesens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"De Clercq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","reference":[{"issue":"7056","key":"b804907f-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nature04017","volume":"437","author":"Ferguson","year":"2005","journal-title":"Nature"},{"issue":"7101","key":"b804907f-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature04795","volume":"442","author":"Ferguson","year":"2006","journal-title":"Nature"},{"key":"b804907f-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1086\/427236","volume":"40","author":"Kaye","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"b804907f-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1056\/NEJMra052211","volume":"353","author":"Beigel","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"b804907f-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3201\/eid1209.05-0979","volume":"12","author":"Taubenberger","year":"2006","journal-title":"Emerging Infect. Dis."},{"key":"b804907f-(cit7a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3201\/eid1201.051254","volume":"12","author":"Kilbourne","year":"2006","journal-title":"Emerging Infect. Dis."},{"key":"b804907f-(cit7b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1056\/NEJMp058281","volume":"353","author":"Beishe","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"b804907f-(cit8a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1002\/j.1460-2075.1985.tb04038.x","volume":"4","author":"Hay","year":"1985","journal-title":"EMBO J."},{"key":"b804907f-(cit8b)\/*[position()=1]","first-page":"21","volume":"3","author":"Hay","year":"1992","journal-title":"Semin. Virol."},{"key":"b804907f-(cit8c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0092-8674(92)90452-I","volume":"69","author":"Pinto","year":"1992","journal-title":"Cell"},{"key":"b804907f-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/protein\/6.1.65","volume":"6","author":"Samson","year":"1993","journal-title":"Protein Eng."},{"key":"b804907f-(cit11a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1021\/jm00044a010","volume":"37","author":"Kolocouris","year":"1994","journal-title":"J. Med. Chem."},{"key":"b804907f-(cit11b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1021\/jm950891z","volume":"39","author":"Kolocouris","year":"1996","journal-title":"J. Med. Chem."},{"key":"b804907f-(cit11c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1177\/095632020301400305","volume":"14","author":"Zoidis","year":"2003","journal-title":"Antiviral Chem. Chemother."},{"key":"b804907f-(cit11d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1016\/j.bmc.2005.12.056","volume":"14","author":"Zoidis","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"b804907f-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/nrd2175","volume":"5","author":"De Clercq","year":"2006","journal-title":"Nat. Rev. Drug Discovery"},{"key":"b804907f-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1172\/JCI200421052","volume":"113","author":"Kennedy","year":"2004","journal-title":"J. Clin. Invest."},{"key":"b804907f-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.pt.2005.08.026","volume":"21","author":"Croft","year":"2005","journal-title":"Trends Parasitol."},{"key":"b804907f-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/oxfordjournals.bmb.a072044","volume":"41","author":"Gutteridge","year":"1985","journal-title":"Br. Med. Bull."},{"key":"b804907f-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0001-706X(93)90090-X","volume":"54","author":"Doua","year":"1993","journal-title":"Acta Trop."},{"key":"b804907f-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ijpara.2006.01.012","volume":"36","author":"Kennedy","year":"2006","journal-title":"Int. J. Parasitol."},{"key":"b804907f-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1128\/AAC.43.4.985","volume":"43","author":"Kelly","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"b804907f-(cit20a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1128\/AAC.45.5.1360-1366.2001","volume":"45","author":"Kelly","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"b804907f-(cit20b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1021\/jm7014292","volume":"51","author":"Papanastasiou","year":"2008","journal-title":"J. Med. Chem."},{"key":"b804907f-(cit21a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1039\/j39700001303","author":"Chakrabarti","year":"1970","journal-title":"J. Chem. Soc. C"},{"key":"b804907f-(cit21b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1039\/p19760001893","author":"Chakrabarti","year":"1976","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"b804907f-(cit21c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1039\/j39680001657","author":"Lunn","year":"1968","journal-title":"J. Chem. Soc. C"},{"key":"b804907f-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1055\/s-2007-973899","volume":"7","author":"Kolocouris","year":"2007","journal-title":"Synlett"},{"key":"b804907f-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.1021\/ja00433a041","volume":"98","author":"Farcasiu","year":"1976","journal-title":"J. Am. Chem. Soc."},{"key":"b804907f-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1021\/jo00439a002","volume":"42","author":"Oldenziel","year":"1977","journal-title":"J. Org. Chem."},{"key":"b804907f-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1039\/jr9480002011","author":"Badger","year":"1948","journal-title":"J. Chem. Soc."},{"key":"b804907f-(cit27)\/*[position()=1]","first-page":"2120","volume":"15","author":"Moiseev","year":"1979","journal-title":"J. Org. Chem. USSR (Engl. Transl.)"},{"key":"b804907f-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/BF00503563","volume":"18","author":"Moiseev","year":"1982","journal-title":"Chem. Heterocycl. Compd. (Engl. Transl.)"},{"key":"b804907f-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/0040-4020(79)85027-9","volume":"35","author":"Scheibye","year":"1979","journal-title":"Tetrahedron"},{"key":"b804907f-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1021\/jo00969a023","volume":"37","author":"Anderson","year":"1972","journal-title":"J. Org. Chem."},{"key":"b804907f-(cit31)\/*[position()=1]","first-page":"1","volume":"15","author":"Schaefer","year":"1967","journal-title":"Org. React."},{"key":"b804907f-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5485","DOI":"10.1016\/j.bmc.2003.09.024","volume":"11","author":"Stamatiou","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"b804907f-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1016\/j.bmcl.2007.04.108","volume":"17","author":"Kolocouris","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"b804907f-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1021\/jm00288a019","volume":"14","author":"Aldrich","year":"1971","journal-title":"J. Med. Chem."},{"key":"b804907f-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0014-5793(02)03851-6","volume":"535","author":"Griffin","year":"2003","journal-title":"FEBS Lett."},{"key":"b804907f-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1126\/science.287.5458.1641","volume":"287","author":"Plugge","year":"2000","journal-title":"Science"},{"key":"b804907f-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0006-8993(94)90821-4","volume":"662","author":"Mizoguchi","year":"1994","journal-title":"Brain Res."}],"container-title":["Organic & Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2008\/OB\/B804907F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:50:20Z","timestamp":1782942620000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/6\/17\/3177-3185\/223250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":42,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1039\/b804907f","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}