{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:41:18Z","timestamp":1790743278691,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2009,7,21]],"date-time":"2009-07-21T00:00:00Z","timestamp":1248134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,7,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Transposable elements (TEs) can donate regulatory sequences that help to control the expression of human genes. The oncogene c-Myc is a promiscuous transcription factor that is thought to regulate the expression of hundreds of genes. We evaluated the contribution of TEs to the c-Myc regulatory network by searching for c-Mycbinding sites derived from TEs and by analyzing the expression and function of target genes with nearby TE-derived c-Mycbinding sites. There are thousands of TE sequences in the human genome that are bound by c-Myc. A conservative analysis indicated that 816-4564 of these TEs contain canonical c-Mycbinding site motifs. c-Mycbinding sites are over-represented among sequences derived from the ancient TE families L2 and MIR, consistent with their preservation by purifying selection. Genes associated with TE-derived c-Mycbinding sites are co-expressed with each other and with c-Myc. A number of these putative TE-derived c-Myc target genes are differentially expressed between Burkitt\u2019s lymphoma cellsversus normal B cells and encode proteins with cancer-related functions. Despite several lines of evidence pointing to their regulation by c-Myc and relevance to cancer, the set of genes identified as TE-derived c-Myc targets does not significantly overlap with two previously characterized c-Myc target gene sets. These data point to a substantial contribution of TEs to the regulation of human genes by c-Myc. Genes that are regulated by TE-derived c-Mycbinding sites appear to form a distinct c-Myc regulatory subnetwork.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/b908494k","type":"journal-article","created":{"date-parts":[[2009,7,21]],"date-time":"2009-07-21T10:00:08Z","timestamp":1248170408000},"page":"1831-1839","source":"Crossref","is-referenced-by-count":22,"title":["A c-Myc regulatory subnetwork from human transposable element sequences"],"prefix":"10.1093","volume":"5","author":[{"given":"Jianrong","family":"Wang","sequence":"first","affiliation":[{"name":"School of Biology, Georgia Institute of Technology a , Atlanta, GA 30332, USA king.jordan@biology.gatech.edu jwang64@gatech.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan J","family":"Bowen","sequence":"additional","affiliation":[{"name":"School of Biology and Ovarian Cancer Institute, Georgia Institute of Technology b , Atlanta, GA 30332, USA bowen@gatech.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Mari\u00f1o-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Computational Biology and Bioinformatics Unit, Bioindustry and Biotechnology Center, Corporaci\u00f3n Colombiana de Investigaci\u00f3n Agropecuaria \u2013 CORPOICA d , Bogota, Colombia"},{"name":"National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health c , Bethesda, MD 20894, USA lmarino@corpoica.org.co"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. 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