{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:34:04Z","timestamp":1790890444593,"version":"4.1.0"},"reference-count":21,"publisher":"Royal Society of Chemistry (RSC)","issue":"44","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Commun."],"published-print":{"date-parts":[[2010]]},"DOI":"10.1039\/c0cc02707c","type":"journal-article","created":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T05:30:15Z","timestamp":1286256615000},"page":"8371","source":"Crossref","is-referenced-by-count":213,"title":["Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency"],"prefix":"10.1039","volume":"46","author":[{"given":"Fabio","family":"Pacchiano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayank","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balendu Sankara","family":"Avvaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur H.","family":"Robbins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Scozzafava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"McKenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","reference":[{"key":"c0cc02707c-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Discovery"},{"key":"c0cc02707c-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"30766","DOI":"10.1074\/jbc.M805353200","volume":"283","author":"Domsic","year":"2008","journal-title":"J. Biol. Chem."},{"key":"c0cc02707c-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1021\/ar9501232","volume":"29","author":"Christianson","year":"1996","journal-title":"Acc. Chem. Res."},{"key":"c0cc02707c-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7697","DOI":"10.1002\/anie.200701189","volume":"46","author":"K\u00f6hler","year":"2007","journal-title":"Angew. Chem., Int. Ed."},{"key":"c0cc02707c-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/prot.340040406","volume":"4","author":"Eriksson","year":"1988","journal-title":"Proteins: Struct., Funct., Genet."},{"key":"c0cc02707c-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.bmcl.2009.11.124","volume":"20","author":"Temperini","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"c0cc02707c-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1021\/ja00087a086","volume":"116","author":"Nair","year":"1994","journal-title":"J. Am. Chem. Soc."},{"key":"c0cc02707c-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1021\/ja809683v","volume":"131","author":"Maresca","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"c0cc02707c-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5511","DOI":"10.1021\/jm1003667","volume":"53","author":"Carta","year":"2010","journal-title":"J. Med. Chem"},{"key":"c0cc02707c-(cit11)\/*[position()=2]","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0223-5234(98)80033-0","volume":"33","author":"Supuran","year":"1998","journal-title":"Eur. J. Med. Chem."},{"key":"c0cc02707c-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4376","DOI":"10.1016\/j.bmcl.2010.06.082","volume":"20","author":"Avvaru","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"c0cc02707c-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4873","DOI":"10.1016\/j.bmc.2010.06.028","volume":"18","author":"Wagner","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"c0cc02707c-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1021\/jm050333c","volume":"48","author":"Menchise","year":"2005","journal-title":"J. Med. Chem."},{"key":"c0cc02707c-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7024","DOI":"10.1021\/jm060807n","volume":"49","author":"Winum","year":"2006","journal-title":"J. Med. Chem."},{"key":"c0cc02707c-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Methods Enzymol"},{"key":"c0cc02707c-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1021\/bi062066y","volume":"42","author":"Fisher","year":"2007","journal-title":"Biochemistry"},{"key":"c0cc02707c-(cit18)\/*[position()=1]","first-page":"213","volume":"D66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr."},{"key":"c0cc02707c-(cit19)\/*[position()=1]","first-page":"1355","volume":"D60","author":"Schuettelkopf","year":"2004","journal-title":"Acta Crystallogr."},{"key":"c0cc02707c-(cit20)\/*[position()=1]","first-page":"2126","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr."},{"key":"c0cc02707c-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","volume":"26","author":"Laskowski","year":"1993","journal-title":"J. Appl. Crystallogr."},{"key":"c0cc02707c-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah","year":"1971","journal-title":"J. Biol. Chem."}],"container-title":["Chemical Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2010\/CC\/C0CC02707C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:42:59Z","timestamp":1783449779000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cc\/article\/46\/44\/8371-8373\/328127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":21,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1039\/c0cc02707c","relation":{},"ISSN":["1359-7345","1364-548X"],"issn-type":[{"value":"1359-7345","type":"print"},{"value":"1364-548X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}