{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:50:34Z","timestamp":1782863434429,"version":"3.54.5"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9,1]]},"DOI":"10.1039\/c0ib00021c","type":"journal-article","created":{"date-parts":[[2010,7,26]],"date-time":"2010-07-26T08:30:39Z","timestamp":1280133039000},"page":"443-451","source":"Crossref","is-referenced-by-count":62,"title":["Monitoring of cell oxygenation and responses to metabolic stimulation by intracellular oxygen sensing technique"],"prefix":"10.1093","volume":"2","author":[{"given":"Alexander V.","family":"Zhdanov","sequence":"first","affiliation":[{"name":"Biochemistry Department, University College Cork, Cavanagh Pharmacy Building, College Road, Cork, Ireland. Fax: + 353-21-4901698; Tel: + 353-21-4901698"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir I.","family":"Ogurtsov","sequence":"additional","affiliation":[{"name":"Tyndall National Institute, University College Cork, Lee Maltings, Prospect Row, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cormac T.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitri B.","family":"Papkovsky","sequence":"additional","affiliation":[{"name":"Biochemistry Department, University College Cork, Cavanagh Pharmacy Building, College Road, Cork, Ireland. Fax: + 353-21-4901698; Tel: + 353-21-4901698"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,7,26]]},"reference":[{"issue":"5847","key":"key\n\t\t\t\t2019012510264066800_cit1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1126\/science.1147949","article-title":"Life with oxygen","volume":"318","author":"Semenza","year":"2007","journal-title":"Science"},{"issue":"1","key":"key\n\t\t\t\t2019012510264066800_cit2","first-page":"H11","article-title":"Quantifying the role of oxygen pressure in tissue function","volume":"294","author":"Wilson","year":"2008","journal-title":"Am. J. Physiol.: Heart Circ. Physiol."},{"issue":"1","key":"key\n\t\t\t\t2019012510264066800_cit3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2008.10.001","article-title":"Oxygen sensors at the crossroad of metabolism","volume":"9","author":"Aragones","year":"2009","journal-title":"Cell Metab."},{"issue":"12","key":"key\n\t\t\t\t2019012510264066800_cit4","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s00109-007-0285-z","article-title":"Hypoxia and human disease-and the Journal of Molecular Medicine","volume":"85","author":"Semenza","year":"2007","journal-title":"J. Mol. Med."},{"issue":"Pt 5","key":"key\n\t\t\t\t2019012510264066800_cit5","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1042\/BST0351119","article-title":"Mechanisms of inflammatory neurodegeneration: iNOS and NADPH oxidase","volume":"35","author":"Brown","year":"2007","journal-title":"Biochem Soc Trans"},{"issue":"5652","key":"key\n\t\t\t\t2019012510264066800_cit6","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1126\/science.1088805","article-title":"Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha","volume":"302","author":"Hagen","year":"2003","journal-title":"Science"},{"issue":"3","key":"key\n\t\t\t\t2019012510264066800_cit7","first-page":"205","article-title":"Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha","volume":"7","author":"Gu","year":"1998","journal-title":"Gene Expr"},{"issue":"9","key":"key\n\t\t\t\t2019012510264066800_cit8","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1073\/pnas.94.9.4273","article-title":"A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development","volume":"94","author":"Ema","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"30","key":"key\n\t\t\t\t2019012510264066800_cit9","doi-asserted-by":"crossref","first-page":"17771","DOI":"10.1074\/jbc.271.30.17771","article-title":"Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1","volume":"271","author":"Jiang","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"50","key":"key\n\t\t\t\t2019012510264066800_cit10","doi-asserted-by":"crossref","first-page":"41504","DOI":"10.1074\/jbc.M510040200","article-title":"Does AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to calcium signaling in O2-sensing cells?","volume":"280","author":"Evans","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"6","key":"key\n\t\t\t\t2019012510264066800_cit11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cmet.2005.05.004","article-title":"Metabolic control through the PGC-1 family of transcription coactivators","volume":"1","author":"Lin","year":"2005","journal-title":"Cell Metab."},{"issue":"7","key":"key\n\t\t\t\t2019012510264066800_cit12","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1073\/pnas.0808801106","article-title":"PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells","volume":"106","author":"O'Hagan","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"key\n\t\t\t\t2019012510264066800_cit13","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.cmet.2005.05.001","article-title":"Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing","volume":"1","author":"Guzy","year":"2005","journal-title":"Cell Metab."},{"issue":"5","key":"key\n\t\t\t\t2019012510264066800_cit14","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1113\/expphysiol.2006.034587","article-title":"Detecting acute changes in oxygen: will the real sensor please stand up?","volume":"91","author":"Kemp","year":"2006","journal-title":"Exp. Physiol."},{"issue":"1","key":"key\n\t\t\t\t2019012510264066800_cit15","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.exger.2005.09.011","article-title":"High-resolution respirometry\u2014a modern tool in aging research","volume":"41","author":"Hutter","year":"2006","journal-title":"Exp. Gerontol."},{"issue":"9","key":"key\n\t\t\t\t2019012510264066800_cit16","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1038\/jcbfm.2008.51","article-title":"Experimental and theoretical studies of oxygen gradients in rat pial microvessels","volume":"28","author":"Sharan","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"6","key":"key\n\t\t\t\t2019012510264066800_cit17","first-page":"H2507","article-title":"Anoxic cell core can promote necrotic cell death in cardiomyocytes at physiological extracellular PO2","volume":"294","author":"Takahashi","year":"2008","journal-title":"Am. J. Physiol.: Heart Circ. Physiol."},{"issue":"6","key":"key\n\t\t\t\t2019012510264066800_cit18","first-page":"H2905","article-title":"PO2 measurements in the microcirculation using phosphorescence quenching microscopy at high magnification","volume":"294","author":"Golub","year":"2008","journal-title":"Am. J. Physiol.: Heart Circ. Physiol."},{"issue":"14","key":"key\n\t\t\t\t2019012510264066800_cit19","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1161\/01.CIR.0000013783.63773.8F","article-title":"Imaging of oxygen transfer among microvessels of rat cremaster muscle","volume":"105","author":"Kobayashi","year":"2002","journal-title":"Circulation"},{"issue":"12","key":"key\n\t\t\t\t2019012510264066800_cit20","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1002\/cphc.200800296","article-title":"Oxygen microscopy by two-photon-excited phosphorescence","volume":"9","author":"Finikova","year":"2008","journal-title":"ChemPhysChem"},{"issue":"4","key":"key\n\t\t\t\t2019012510264066800_cit21","doi-asserted-by":"crossref","first-page":"R1613","DOI":"10.1152\/ajpregu.00707.2006","article-title":"Sensing intracellular oxygen using near-infrared phosphorescent probes and live-cell fluorescence imaging","volume":"292","author":"O'Riordan","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"24","key":"key\n\t\t\t\t2019012510264066800_cit22","doi-asserted-by":"crossref","first-page":"9414","DOI":"10.1021\/ac701770b","article-title":"Analysis of intracellular oxygen and metabolic responses of mammalian cells by time-resolved fluorometry","volume":"79","author":"O'Riordan","year":"2007","journal-title":"Anal. Chem."},{"issue":"51","key":"key\n\t\t\t\t2019012510264066800_cit23","doi-asserted-by":"crossref","first-page":"36790","DOI":"10.1074\/jbc.M700327200","article-title":"Detection of reactive oxygen species via endogenous oxidative pentose phosphate cycle activity in response to oxygen concentration: implications for the mechanism of HIF-1alpha stabilization under moderate hypoxia","volume":"282","author":"Tuttle","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"2","key":"key\n\t\t\t\t2019012510264066800_cit24","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0034-5687(94)00125-J","article-title":"Pericellular PO2 and O2 consumption in monolayer cell cultures","volume":"100","author":"Metzen","year":"1995","journal-title":"Respir. Physiol."},{"issue":"3","key":"key\n\t\t\t\t2019012510264066800_cit25","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/bit.20348","article-title":"Gas sensing in microplates with optodes: influence of oxygen exchange between sample, air, and plate material","volume":"90","author":"Arain","year":"2005","journal-title":"Biotechnol. Bioeng."},{"issue":"9","key":"key\n\t\t\t\t2019012510264066800_cit26","doi-asserted-by":"crossref","first-page":"5650","DOI":"10.1074\/jbc.M706439200","article-title":"Dynamics of intracellular oxygen in PC12 Cells upon stimulation of neurotransmission","volume":"283","author":"Zhdanov","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"2","key":"key\n\t\t\t\t2019012510264066800_cit27","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1517\/17425255.2.2.313","article-title":"Respirometric Screening Technology for ADME-Tox studies","volume":"2","author":"Papkovsky","year":"2006","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"issue":"3","key":"key\n\t\t\t\t2019012510264066800_cit28","first-page":"473","article-title":"Transmitter, ion channel and receptor properties of pheochromocytoma (PC12) cells: a model for neurotoxicological studies","volume":"12","author":"Shafer","year":"1991","journal-title":"Neurotoxicology"},{"issue":"1","key":"key\n\t\t\t\t2019012510264066800_cit29","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.mbs.2007.04.008","article-title":"A multiscale theoretical model for diffusive mass transfer in cellular biological media","volume":"210","author":"Kapellos","year":"2007","journal-title":"Math. Biosci."},{"issue":"26","key":"key\n\t\t\t\t2019012510264066800_cit30","doi-asserted-by":"crossref","first-page":"15392","DOI":"10.1016\/S0021-9258(18)55409-0","article-title":"Cellular energetics and the oxygen dependence of respiration in cardiac myocytes isolated from adult rat","volume":"265","author":"Rumsey","year":"1990","journal-title":"J Biol Chem"},{"issue":"2","key":"key\n\t\t\t\t2019012510264066800_cit31","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/toxsci\/kfm052","article-title":"Circumventing the Crabtree Effect: Replacing Media Glucose with Galactose Increases Susceptibility of HepG2 Cells to Mitochondrial Toxicants","volume":"97","author":"Marroquin","year":"2007","journal-title":"Toxicol. Sci."},{"issue":"5","key":"key\n\t\t\t\t2019012510264066800_cit32","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1152\/japplphysiol.00893.2002","article-title":"Effect of extracellular PO2 on the fall in intracellular PO2 in contracting single myocytes","volume":"94","author":"Kindig","year":"2003","journal-title":"J Appl Physiol"},{"key":"key\n\t\t\t\t2019012510264066800_cit33","article-title":"Extracellular calcium depletion transiently elevates oxygen consumption in neurosecretory PC12 cells through activation of mitochondrial Na(+)\/Ca(2+) exchange","volume-title":"Biochim Biophys Acta","author":"Zhdanov","year":"2010"},{"issue":"2\u20133","key":"key\n\t\t\t\t2019012510264066800_cit34","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0014-5793(94)01290-3","article-title":"Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase","volume":"356","author":"Brown","year":"1994","journal-title":"FEBS Lett."},{"issue":"47","key":"key\n\t\t\t\t2019012510264066800_cit35","doi-asserted-by":"crossref","first-page":"18508","DOI":"10.1073\/pnas.0709440104","article-title":"Cytochrome c oxidase regulates endogenous nitric oxide availability in respiring cells: a possible explanation for hypoxic vasodilation","volume":"104","author":"Palacios-Callender","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"key\n\t\t\t\t2019012510264066800_cit36","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1089\/ars.2007.1959","article-title":"Nitric oxide in the vasculature: where does it come from and where does it go? A quantitative perspective","volume":"10","author":"Chen","year":"2008","journal-title":"Antioxid. Redox Signaling"},{"key":"key\n\t\t\t\t2019012510264066800_cit37","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.109.197228","article-title":"Regulation of Oxygen Distribution in Tissues by Endothelial Nitric Oxide","author":"Victor","year":"2009","journal-title":"Circ Res"},{"issue":"6","key":"key\n\t\t\t\t2019012510264066800_cit38","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1073\/pnas.041603998","article-title":"Nitric oxide-induced cytostasis and cell cycle arrest of a human breast cancer cell line (MDA-MB-231): potential role of cyclin D1","volume":"98","author":"Pervin","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"17","key":"key\n\t\t\t\t2019012510264066800_cit39","doi-asserted-by":"crossref","first-page":"6480","DOI":"10.1523\/JNEUROSCI.21-17-06480.2001","article-title":"Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity","volume":"21","author":"Bal-Price","year":"2001","journal-title":"J Neurosci"},{"issue":"1\u20132","key":"key\n\t\t\t\t2019012510264066800_cit40","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/jnr.20285","article-title":"Nitric oxide from inflammatory-activated glia synergizes with hypoxia to induce neuronal death","volume":"79","author":"Mander","year":"2005","journal-title":"J. Neurosci. Res."},{"issue":"32","key":"key\n\t\t\t\t2019012510264066800_cit41","doi-asserted-by":"crossref","first-page":"22575","DOI":"10.1074\/jbc.M600288200","article-title":"Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment","volume":"281","author":"Bracken","year":"2006","journal-title":"J. Biol. Chem."}],"container-title":["Integrative Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ib\/article-pdf\/2\/9\/443\/27327548\/c0ib00021c.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T13:20:49Z","timestamp":1635772849000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ib\/article\/2\/9\/443\/5210980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,26]]},"references-count":41,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2010,7,26]]},"published-print":{"date-parts":[[2010,9,1]]}},"URL":"https:\/\/doi.org\/10.1039\/c0ib00021c","relation":{},"ISSN":["1757-9708"],"issn-type":[{"value":"1757-9708","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2010,9]]},"published":{"date-parts":[[2010,7,26]]}}}