{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:45:47Z","timestamp":1788392747279,"version":"build-2803163510"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2010,11,30]],"date-time":"2010-11-30T00:00:00Z","timestamp":1291075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic acid methyl ester (MIAM) was provided as a DNA-intercalator. For the comprehensive evaluation of this new intercalator, an assay system consisting of cell, S180 mouse, healthy mouse, spectrum, non-spectrum, and gel electrophoresis models was constructed. On the cell (S180, K562, MCF-7, HeLa and HepG2) models, MIAM selectively inhibited the viability of HeLa. On the S180 mouse model, 0.89, 8.9, 89 and 890 \u03bcmol kg\u22121 of MIAM dose-dependently inhibited the tumor growth. Even at a dose of 890 \u03bcmol kg\u22121, MIAM did not damage the treated S180 mice. The safety of MIAM was supported by a high spleen index and an obvious increase of body weight of the treated S180 mice. On the healthy mouse model the LD50 value of MIAM is higher than 890 \u03bcmol kg\u22121. The ultraviolet (UV), fluorescence, circular dichroism (CD), relative viscosity, melting curve, and gel electrophoresis assays of DNA with or without MIAM consistently supported an intercalation mechanism for MIAM.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/c0mb00049c","type":"journal-article","created":{"date-parts":[[2010,11,30]],"date-time":"2010-11-30T05:45:00Z","timestamp":1291095900000},"page":"766-772","source":"Crossref","is-referenced-by-count":11,"title":["{2-[1-(3-Methoxycarbonylmethyl-1\n                    <i>H<\/i>\n                    -indol-2-yl)-1-methyl-ethyl]-1\n                    <i>H<\/i>\n                    -indol-3-yl}-acetic acid methyl ester (MIAM): Its anti-cancer efficacy and intercalation mechanism identified\n                    <i>via<\/i>\n                    multi-model systems"],"prefix":"10.1093","volume":"7","author":[{"given":"Wenjing","family":"Wang","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Sciences, Capital Medical University a , Beijing 1000 69 P.R. China shiqipeng@163.com sqpeng@bjmu.edu.cn mingzhao@bjmu.edu.cn +86-10-8391-1528 +86-10-8280-2482 +86-10-8391-1528 +86-10-8280-2482"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Capital Medical University a , Beijing 1000 69 P.R. China shiqipeng@163.com sqpeng@bjmu.edu.cn mingzhao@bjmu.edu.cn +86-10-8391-1528 +86-10-8280-2482 +86-10-8391-1528 +86-10-8280-2482"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Capital Medical University a , Beijing 1000 69 P.R. China shiqipeng@163.com sqpeng@bjmu.edu.cn mingzhao@bjmu.edu.cn +86-10-8391-1528 +86-10-8280-2482 +86-10-8391-1528 +86-10-8280-2482"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawang","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Capital Medical University a , Beijing 1000 69 P.R. China shiqipeng@163.com sqpeng@bjmu.edu.cn mingzhao@bjmu.edu.cn +86-10-8391-1528 +86-10-8280-2482 +86-10-8391-1528 +86-10-8280-2482"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhui","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Capital Medical University a , Beijing 1000 69 P.R. 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