{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:59:23Z","timestamp":1787003963791,"version":"build-2736575974"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2011,2,19]],"date-time":"2011-02-19T00:00:00Z","timestamp":1298073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,2,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Schistosomiasis is a parasitic infection that is endemic in many developing countries in the tropics and subtropics afflicting more than 207 million people primarily in rural areas. After malaria, it is the second most important parasitic infection in terms of socio-economic and public health. Investigation of the host\u2013parasite interaction at the molecular level and identification of biomarkers of infection and infection-related morbidity would be of value for improved strategies for treatment and morbidity control. To this end, we conducted a nuclear magnetic resonance (NMR) based metabonomics study involving a well-characterized cohort of 447 individuals from a rural area in Uganda near Lake Victoria with a high prevalence of Schistosoma mansoni, a species predominantly occurring in Africa including Madagascar and parts of South America. Cohort samples were collected from individuals at five time-points, before and after (one or two times) chemotherapy with praziquantel (PZQ). Using supervised multivariate statistical analysis of the recorded one-dimensional (1D) NMR spectra, we were able to discriminate infected from uninfected individuals in two age groups (children and adults) based on differences in their urinary profiles. The potential molecular markers of S. mansoni infection were found to be primarily linked to changes in gut microflora, energy metabolism and liver function. These findings are in agreement with data from earlier studies on S. mansoni infection in experimental animals and thus provide corroborating evidence for the existence of metabolic response specific for this infection.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/c0mb00262c","type":"journal-article","created":{"date-parts":[[2011,2,19]],"date-time":"2011-02-19T09:00:42Z","timestamp":1298106042000},"page":"1473-1480","source":"Crossref","is-referenced-by-count":58,"title":["Metabonomic investigation of human\n                    <i>Schistosoma mansoni<\/i>\n                    infection"],"prefix":"10.1093","volume":"7","author":[{"given":"Crina I A","family":"Balog","sequence":"first","affiliation":[{"name":"Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center a , P.O. Box 9600, 2300 RC Leiden The Netherlands a.meissner@lumc.nl +31 71 526 6907 +31 71 526 5062"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Meissner","sequence":"additional","affiliation":[{"name":"Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center a , P.O. Box 9600, 2300 RC Leiden The Netherlands a.meissner@lumc.nl +31 71 526 6907 +31 71 526 5062"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibel","family":"G\u00f6raler","sequence":"additional","affiliation":[{"name":"Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center a , P.O. Box 9600, 2300 RC Leiden The Netherlands a.meissner@lumc.nl +31 71 526 6907 +31 71 526 5062"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco R","family":"Bladergroen","sequence":"additional","affiliation":[{"name":"Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center a , P.O. Box 9600, 2300 RC Leiden The Netherlands a.meissner@lumc.nl +31 71 526 6907 +31 71 526 5062"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte J","family":"Vennervald","sequence":"additional","affiliation":[{"name":"DBL\u2014Centre for Health Research and Development, Faculty of Life Sciences, University of Copenhagen b , Thorvaldsenvej 57, 1871 Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg A","family":"Mayboroda","sequence":"additional","affiliation":[{"name":"Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center a , P.O. Box 9600, 2300 RC Leiden The Netherlands a.meissner@lumc.nl +31 71 526 6907 +31 71 526 5062"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 M","family":"Deelder","sequence":"additional","affiliation":[{"name":"Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center a , P.O. Box 9600, 2300 RC Leiden The Netherlands a.meissner@lumc.nl +31 71 526 6907 +31 71 526 5062"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,2,19]]},"reference":[{"key":"2026012913154490500_cit1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1473-3099(06)70521-7","volume":"6","author":"Steinmann","year":"2006","journal-title":"Lancet Infect. Dis."},{"key":"2026012913154490500_cit2","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/0035-9203(95)90498-0","volume":"89","author":"Boisier","year":"1995","journal-title":"Trans. R. Soc. Trop. Med. 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