{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:13:09Z","timestamp":1770819189129,"version":"3.50.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2011,3,15]],"date-time":"2011-03-15T00:00:00Z","timestamp":1300147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Multidrug resistance (MDR) mediated by the over expression of drug efflux proteinP-glycoprotein (P-gp) is one of the major impediments to successful treatment of cancer. P-gp acts as an energy-dependent drug efflux pump and reduces the intracellular concentration of structurally unrelated drugs inside the cells. Therefore, there is an urgent need for development of new molecules that are less toxic to normal cell and preferentially effective against drug resistant malignant cells. In this preclinical study we report the apoptotic potential of copper N-(2-hydroxyacetophenone) glycinate (CuNG) on doxorubicin resistant T lymphoblastic leukaemia cells (CEM\/ADR5000). To evaluate the cytotoxic effect of CuNG, we used different normal cell lines (NIH 3T3, Chang liver and human PBMC) and cancerous cell lines (CEM\/ADR5000, parental sensitive CCRF-CEM, SiHa and 3LL) and conclude that CuNG preferentially kills cancerous cells, especially both leukemic cell types irrespective of their MDR status, while leaving normal cell totally unaffected. Moreover, CuNG involves reactive oxygen species (ROS) for induction of apoptosis in CEM\/ADR5000cells through the intrinsic apoptotic pathway. This is substantiated by our observation that antioxidantN-acetyle-cysteine (NAC) and PEG catalase could completely block ROS generation and, subsequently, abrogates CuNG induced apoptosis. On the other hand, uncomplexed ligand N-(2-hydroxyacetophenone) glycinate (NG) fails to generate a significant amount of ROS and concomitant induction of apoptosis in CEM\/ADR5000cells. Therefore, CuNG induces drug resistant leukemia cells to undergo apoptosis and proves to be a molecule having therapeutic potential to overcome MDR in cancer.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/c0mb00306a","type":"journal-article","created":{"date-parts":[[2011,3,15]],"date-time":"2011-03-15T09:31:58Z","timestamp":1300181518000},"page":"1701-1712","source":"Crossref","is-referenced-by-count":31,"title":["Redox active copper chelate overcomes multidrug resistance in T-lymphoblastic leukemia cell by triggering apoptosis"],"prefix":"10.1093","volume":"7","author":[{"given":"Avishek","family":"Ganguly","sequence":"first","affiliation":[{"name":"Department of In vitro Carcinogenesis and Cellular Chemotherapy, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Calcutta 700 026, India a soumitra01@yahoo.com 91-33-2475-7606 91-33-2476-5101\/02\/04, ext. 332"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumya","family":"Basu","sequence":"additional","affiliation":[{"name":"Department of In vitro Carcinogenesis and Cellular Chemotherapy, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Calcutta 700 026, India a soumitra01@yahoo.com 91-33-2475-7606 91-33-2476-5101\/02\/04, ext. 332"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaushik","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of In vitro Carcinogenesis and Cellular Chemotherapy, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Calcutta 700 026, India a soumitra01@yahoo.com 91-33-2475-7606 91-33-2476-5101\/02\/04, ext. 332"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paramita","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of In vitro Carcinogenesis and Cellular Chemotherapy, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Calcutta 700 026, India a soumitra01@yahoo.com 91-33-2475-7606 91-33-2476-5101\/02\/04, ext. 332"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avijit","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Dept. of Pharmacology, Institute of Post Graduate Medical Education and Research, Kolkata, India b"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitali","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Dept. of Pharmacology, Institute of Post Graduate Medical Education and Research, Kolkata, India b"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumitra Kumar","family":"Chaudhuri","sequence":"additional","affiliation":[{"name":"Department of In vitro Carcinogenesis and Cellular Chemotherapy, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Calcutta 700 026, India a soumitra01@yahoo.com 91-33-2475-7606 91-33-2476-5101\/02\/04, ext. 332"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,3,15]]},"reference":[{"issue":"1A","key":"2026012913161312900_cit1","first-page":"107","article-title":"Modulation of multidrug-resistance gene expression in human breast cancer cells by (\u2212)-gossypolenriched cottonseed oil","volume":"27","author":"Ye","year":"2007","journal-title":"Anticancer Res."},{"issue":"4","key":"2026012913161312900_cit2","first-page":"1","article-title":"Cancer multidrug resistance: A review of recent drug discovery research","volume":"5","author":"Liscovitch","year":"2002","journal-title":"I Drugs."},{"key":"2026012913161312900_cit3","first-page":"1977","article-title":"Modulation of vinblastine resistance in metastatic renal cell carcinoma with cyclosporine A or tamoxifen: a cancer and leukemia group B study","volume":"3","author":"Samuels","year":"1997","journal-title":"Clin Cancer Res."},{"key":"2026012913161312900_cit4","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/0959-8049(96)00091-3","article-title":"Clinical trials of P-glycoprotein reversal in solid tumours","volume":"32","author":"Ferry","year":"1996","journal-title":"Eur. 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