{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T15:48:08Z","timestamp":1776354488698,"version":"3.51.2"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2011,6,7]],"date-time":"2011-06-07T00:00:00Z","timestamp":1307404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dynamical modeling is an accurate tool for describing the dynamic regulation of one-carbon metabolism (1CM) with emphasis on the alteration of DNA methylation and\/or dUMPmethylation into dTMP. Using logic programming we present a comprehensive and adaptative mathematical model to study the impact of folate deficiency, including folate transport and enzymes activities. 5-Methyltetrahydrofolate (5mTHF) uptake and DNA and dUMPmethylation were studied by simulating nutritional 5mTHF deficiency and methylenetetrahydrofolate reductase (MTHFR) gene defects. Both conditions had distinct effects on 1CM metabolite synthesis. Simulating severe 5mTHF deficiency (25% of normal levels) modulated 11 metabolites. However, simulating a severe decrease in MTHFR activity (25% of normal activity) modulated another set of metabolites. Two oscillations of varying amplitude were observed at the steady state for DNA methylation with severe 5mTHF deficiency, and the dUMP\/dTMP ratio reached a steady state after 2 h, compared to 2.5 h for 100% 5mTHF. MTHFR activity with 25% of Vmax resulted in an increased methylated DNA pool after half an hour. We observed a deviation earlier in the profile compared to 50% and 100% Vmax. For dUMPmethylation, the highest level was observed with 25%, suggesting a low rate of dUMPmethylation into dTMP with 25% of MTHFR activity. In conclusion, using logic programming we were able to construct the 1CM for analyzing the dynamic system behavior. This model may be used to refine biological interpretations of data or as a tool that can provide new hypotheses for pathogenesis.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/c1mb05102d","type":"journal-article","created":{"date-parts":[[2011,6,7]],"date-time":"2011-06-07T07:10:19Z","timestamp":1307430619000},"page":"2508-2521","source":"Crossref","is-referenced-by-count":8,"title":["Using logic programming for modeling the one-carbon metabolism network to study the impact of folate deficiency on methylation processes"],"prefix":"10.1093","volume":"7","author":[{"given":"Etienne Z","family":"Gnimpieba","sequence":"first","affiliation":[{"name":"Nutritional Genomics & applied bioinformatics, UPSP 2007.05.137 EGEAL., Institut Polytechnique Lasalle Beauvais a , 19 rue Pierre Waguet, F-60026 Beauvais Cedex France abalo.chango@lasalle-beauvais.fr +33 3 44 06 25 26"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Eveillard","sequence":"additional","affiliation":[{"name":"Computational Biology Group LINA UMR6241-Universit\u00e9 de Nantes, EMN, CNRS b , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Louis","family":"Gu\u00e9ant","sequence":"additional","affiliation":[{"name":"INSERM U954 c , Vand\u0153uvre-les-Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abalo","family":"Chango","sequence":"additional","affiliation":[{"name":"Nutritional Genomics & applied bioinformatics, UPSP 2007.05.137 EGEAL., Institut Polytechnique Lasalle Beauvais a , 19 rue Pierre Waguet, F-60026 Beauvais Cedex France abalo.chango@lasalle-beauvais.fr +33 3 44 06 25 26"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,6,7]]},"reference":[{"key":"2026011013471795900_cit1","volume-title":"Biochemistry","author":"Mathews","year":"1990"},{"issue":"11","key":"2026011013471795900_cit2","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1093\/carcin\/bgm149","article-title":"Folate receptor and human reduced folate carrier expression in HepG2 cell line exposed to fumonisin B1 and folate deficiency","volume":"28","author":"Abdel Nour","year":"2007","journal-title":"Carcinogenesis"},{"issue":"5","key":"2026011013471795900_cit3","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.cell.2006.09.041","article-title":"et al., Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption","volume":"127","author":"Qiu","year":"2006","journal-title":"Cell (Cambridge, Mass.)"},{"issue":"1","key":"2026011013471795900_cit4","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/0006-291X(82)91872-1","article-title":"Regulation of hepatic betaine\u2013homocysteine methyltransferase by dietary methionine","volume":"108","author":"Finkelstein","year":"1982","journal-title":"Biochem. 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