{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:20:20Z","timestamp":1788171620146,"version":"build-2803163510"},"reference-count":25,"publisher":"Royal Society of Chemistry (RSC)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Analyst"],"DOI":"10.1039\/c2an36364j","type":"journal-article","created":{"date-parts":[[2012,11,6]],"date-time":"2012-11-06T10:30:38Z","timestamp":1352197838000},"page":"339-345","source":"Crossref","is-referenced-by-count":11,"title":["Using droplet-based microfluidic technology to study the precipitation of a poorly water-soluble weakly basic drug upon a pH-shift"],"prefix":"10.1039","volume":"138","author":[{"given":"Francine","family":"Edwards","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Tsakmaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Mohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Fielden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick J.","family":"Goddard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Booth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kin Y.","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2013]]},"reference":[{"key":"C2AN36364J-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv. Drug Delivery Rev."},{"key":"C2AN36364J-(cit2)\/*[position()=1]","volume-title":"Water-Insoluble Drug Formulation","year":"2000","unstructured":"Water-Insoluble Drug Formulation, ed. R. Liu, CRC Press LLC, 2000"},{"key":"C2AN36364J-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1002\/jps.21650","volume":"98","author":"Brouwers","year":"2009","journal-title":"J. Pharm. Sci."},{"key":"C2AN36364J-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.addr.2007.05.006","volume":"59","author":"Hauss","year":"2007","journal-title":"Adv. Drug Delivery Rev."},{"key":"C2AN36364J-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1248\/cpb.46.482","volume":"46","author":"Suzuki","year":"1998","journal-title":"Chem. Pharm. Bull."},{"key":"C2AN36364J-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1080\/03639040801929273","volume":"34","author":"Miller","year":"2008","journal-title":"Drug Dev. Ind. Pharm."},{"key":"C2AN36364J-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1211\/0022357022511","volume":"56","author":"Kostewicz","year":"2004","journal-title":"J. Pharm. Pharmacol."},{"key":"C2AN36364J-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ijpharm.2007.05.006","volume":"342","author":"Vandecruys","year":"2007","journal-title":"Int. J. Pharm."},{"key":"C2AN36364J-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1002\/jps.20886","volume":"96","author":"Dai","year":"2007","journal-title":"J. Pharm. Sci."},{"key":"C2AN36364J-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1107\/S0907444908028060","volume":"64","author":"Gerdts","year":"2008","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"key":"C2AN36364J-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8156","DOI":"10.1002\/anie.200602946","volume":"45","author":"Gerdts","year":"2006","journal-title":"Angew. Chem., Int. Ed."},{"key":"C2AN36364J-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1021\/cg700688f","volume":"7","author":"Shim","year":"2007","journal-title":"Cryst. Growth Des."},{"key":"C2AN36364J-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1039\/b700799j","volume":"7","author":"Laval","year":"2007","journal-title":"Lab Chip"},{"key":"C2AN36364J-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1021\/la802695r","volume":"25","author":"Laval","year":"2009","journal-title":"Langmuir"},{"key":"C2AN36364J-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.ejps.2009.04.007","volume":"37","author":"Ali","year":"2009","journal-title":"Eur. J. Pharm. Sci."},{"key":"C2AN36364J-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1177\/106002807701100703","volume":"11","author":"Yalkowsky","year":"1977","journal-title":"Drug Intell. Clin. Pharm."},{"key":"C2AN36364J-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1002\/jps.10396","volume":"92","author":"Johnson","year":"2003","journal-title":"J. Pharm. Sci."},{"key":"C2AN36364J-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/jps.2600750504","volume":"75","author":"Baxter","year":"1986","journal-title":"J. Pharm. Sci."},{"key":"C2AN36364J-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1023\/A:1011984216775","volume":"15","author":"Dressman","year":"1998","journal-title":"Pharm. Res."},{"key":"C2AN36364J-(cit20)\/*[position()=1]","volume-title":"Physician's Desk Reference","year":"2009","unstructured":"Physician's Desk Reference, PDR Network LLC, 2009"},{"key":"C2AN36364J-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/j.2042-7158.1988.tb06996.x","volume":"40","author":"Walter","year":"1988","journal-title":"J. Pharm. Pharmacol."},{"key":"C2AN36364J-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/bdd.670","volume":"30","author":"Diakidou","year":"2009","journal-title":"Biopharm. Drug Dispos."},{"key":"C2AN36364J-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1007\/s11095-010-0223-6","volume":"27","author":"Vertzoni","year":"2010","journal-title":"Pharm. Res."},{"key":"C2AN36364J-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1023\/A:1018943613122","volume":"10","author":"Davies","year":"1993","journal-title":"Pharm. Res."},{"key":"C2AN36364J-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1002\/jps.22579","volume":"100","author":"Alonzo","year":"2011","journal-title":"J. Pharm. Sci."}],"container-title":["The Analyst"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2013\/AN\/C2AN36364J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:36:54Z","timestamp":1782963414000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/an\/article\/138\/1\/339-345\/358937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1039\/c2an36364j","relation":{},"ISSN":["0003-2654","1364-5528"],"issn-type":[{"value":"0003-2654","type":"print"},{"value":"1364-5528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}