{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:08:14Z","timestamp":1791248894090,"version":"4.1.0"},"reference-count":53,"publisher":"Royal Society of Chemistry (RSC)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lab Chip"],"published-print":{"date-parts":[[2012]]},"DOI":"10.1039\/c2lc21019c","type":"journal-article","created":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T07:00:26Z","timestamp":1329721226000},"page":"1320","source":"Crossref","is-referenced-by-count":108,"title":["Microfluidic platform for combinatorial synthesis in picolitre droplets"],"prefix":"10.1039","volume":"12","author":[{"given":"Ashleigh B.","family":"Theberge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Mayot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdeslam","family":"El Harrak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Kleinschmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm T. S.","family":"Huck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","reference":[{"key":"c2lc21019c-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1021\/cr040674i","volume":"106","author":"Rubin","year":"2006","journal-title":"Chem. Rev."},{"key":"c2lc21019c-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1021\/cr990014r","volume":"100","author":"An","year":"2000","journal-title":"Chem. Rev."},{"key":"c2lc21019c-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7336","DOI":"10.1002\/anie.200601554","volume":"45","author":"Song","year":"2006","journal-title":"Angew. Chem., Int. Ed."},{"key":"c2lc21019c-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1039\/b715524g","volume":"8","author":"Teh","year":"2008","journal-title":"Lab Chip"},{"key":"c2lc21019c-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1021\/ar8002464","volume":"42","author":"Chiu","year":"2009","journal-title":"Acc. Chem. Res."},{"key":"c2lc21019c-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5846","DOI":"10.1002\/anie.200906653","volume":"49","author":"Theberge","year":"2010","journal-title":"Angew. Chem., Int. Ed."},{"key":"c2lc21019c-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.chembiol.2008.04.004","volume":"15","author":"Clausell-Tormos","year":"2008","journal-title":"Chem. Biol."},{"key":"c2lc21019c-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14195","DOI":"10.1073\/pnas.0903542106","volume":"106","author":"Brouzes","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"c2lc21019c-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1002\/anie.200804326","volume":"48","author":"Joensson","year":"2009","journal-title":"Angew. Chem., Int. Ed."},{"key":"c2lc21019c-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15251","DOI":"10.1021\/ja904823z","volume":"131","author":"Shim","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"c2lc21019c-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.chembiol.2010.04.010","volume":"17","author":"Baret","year":"2010","journal-title":"Chem. Biol."},{"key":"c2lc21019c-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/anie.201006089","volume":"50","author":"Novak","year":"2011","journal-title":"Angew. Chem., Int. Ed."},{"key":"c2lc21019c-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1073\/pnas.0910781107","volume":"107","author":"Agresti","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"c2lc21019c-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1002\/anie.200503925","volume":"45","author":"Poe","year":"2006","journal-title":"Angew. Chem., Int. Ed."},{"key":"c2lc21019c-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1002\/ceat.200500147","volume":"28","author":"\u00d6nal","year":"2005","journal-title":"Chem. Eng. Technol."},{"key":"c2lc21019c-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/adsc.200505480","volume":"348","author":"Ahmed","year":"2006","journal-title":"Adv. Synth. Catal."},{"key":"c2lc21019c-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6225","DOI":"10.1039\/b911594c","author":"Theberge","year":"2009","journal-title":"Chem. Commun."},{"key":"c2lc21019c-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1002\/anie.200462857","volume":"44","author":"Zheng","year":"2005","journal-title":"Angew. Chem., Int. Ed."},{"key":"c2lc21019c-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7722","DOI":"10.1021\/ac061205e","volume":"78","author":"Chabert","year":"2006","journal-title":"Anal. Chem."},{"key":"c2lc21019c-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16843","DOI":"10.1073\/pnas.0807916105","volume":"105","author":"Chen","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"c2lc21019c-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1002\/anie.200805396","volume":"48","author":"Edgar","year":"2009","journal-title":"Angew. Chem., Int. Ed."},{"key":"c2lc21019c-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1021\/ac1005316","volume":"82","author":"Theberge","year":"2010","journal-title":"Anal. Chem."},{"key":"c2lc21019c-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1039\/c004768f","volume":"10","author":"Trivedi","year":"2010","journal-title":"Lab Chip"},{"key":"c2lc21019c-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9941","DOI":"10.1021\/ac1020479","volume":"82","author":"Du","year":"2010","journal-title":"Anal. Chem."},{"key":"c2lc21019c-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1039\/b921754a","volume":"10","author":"Clausell-Tormos","year":"2010","journal-title":"Lab Chip"},{"key":"c2lc21019c-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1002\/anie.199522801","volume":"34","author":"Weber","year":"1995","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"c2lc21019c-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S1074-5521(00)00122-8","volume":"7","author":"Illgen","year":"2000","journal-title":"Chem. Biol."},{"key":"c2lc21019c-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1039\/b806706f","volume":"8","author":"Holtze","year":"2008","journal-title":"Lab Chip"},{"key":"c2lc21019c-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/(SICI)1522-2683(20000101)21:1<27::AID-ELPS27>3.0.CO;2-C","volume":"21","author":"McDonald","year":"2000","journal-title":"Electrophoresis"},{"key":"c2lc21019c-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/adma.200601787","volume":"19","author":"Siegel","year":"2007","journal-title":"Adv. Mater."},{"key":"c2lc21019c-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6877","DOI":"10.1002\/anie.200602273","volume":"45","author":"Siegel","year":"2006","journal-title":"Angew. Chem., Int. Ed."},{"key":"c2lc21019c-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1063\/1.1537519","volume":"82","author":"Anna","year":"2003","journal-title":"Appl. Phys. Lett."},{"key":"c2lc21019c-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"R319","DOI":"10.1088\/0022-3727\/40\/19\/R01","volume":"40","author":"Christopher","year":"2007","journal-title":"J. Phys. D: Appl. Phys."},{"key":"c2lc21019c-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3706","DOI":"10.1002\/elps.200500109","volume":"26","author":"Chabert","year":"2005","journal-title":"Electrophoresis"},{"key":"c2lc21019c-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1002\/anie.200503540","volume":"45","author":"Link","year":"2006","journal-title":"Angew. Chem., Int. Ed."},{"key":"c2lc21019c-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"264105","DOI":"10.1063\/1.2218058","volume":"88","author":"Ahn","year":"2006","journal-title":"Appl. Phys. Lett."},{"key":"c2lc21019c-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"134101","DOI":"10.1063\/1.2357039","volume":"89","author":"Priest","year":"2006","journal-title":"Appl. Phys. Lett."},{"key":"c2lc21019c-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1021\/cr0505728","volume":"106","author":"D\u00f6mling","year":"2006","journal-title":"Chem. Rev."},{"key":"c2lc21019c-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.cbpa.2008.02.004","volume":"12","author":"Akritopoulou-Zanze","year":"2008","journal-title":"Curr. Opin. Chem. Biol."},{"key":"c2lc21019c-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1056\/NEJMra044440","volume":"353","author":"Di Nisio","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"c2lc21019c-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.275.5301.823","volume":"275","author":"Studer","year":"1997","journal-title":"Science"},{"key":"c2lc21019c-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6088","DOI":"10.1021\/la9000472","volume":"25","author":"Baret","year":"2009","journal-title":"Langmuir"},{"key":"c2lc21019c-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/nbt.1583","volume":"27","author":"Tewhey","year":"2009","journal-title":"Nat. Biotechnol."},{"key":"c2lc21019c-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1039\/B816049J","volume":"9","author":"Frenz","year":"2009","journal-title":"Lab Chip"},{"key":"c2lc21019c-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1073\/pnas.1113324109","volume":"109","author":"Miller","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"c2lc21019c-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1126\/science.1134929","volume":"315","author":"Pregibon","year":"2007","journal-title":"Science"},{"key":"c2lc21019c-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"024104","DOI":"10.1063\/1.2164911","volume":"88","author":"Ahn","year":"2006","journal-title":"Appl. Phys. Lett."},{"key":"c2lc21019c-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1002\/anie.200704903","volume":"47","author":"Fidalgo","year":"2008","journal-title":"Angew. Chem., Int. Ed."},{"key":"c2lc21019c-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1039\/b902504a","volume":"9","author":"Baret","year":"2009","journal-title":"Lab Chip"},{"key":"c2lc21019c-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1002\/anie.200806103","volume":"48","author":"Fidalgo","year":"2009","journal-title":"Angew. Chem., Int. Ed."},{"key":"c2lc21019c-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6832","DOI":"10.1002\/anie.200902501","volume":"48","author":"Kelly","year":"2009","journal-title":"Angew. Chem., Int. Ed."},{"key":"c2lc21019c-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6558","DOI":"10.1021\/ac901172a","volume":"81","author":"Pei","year":"2009","journal-title":"Anal. Chem."},{"key":"c2lc21019c-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8361","DOI":"10.1021\/ac101902c","volume":"82","author":"Zhu","year":"2010","journal-title":"Anal. Chem."}],"container-title":["Lab on a Chip"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2012\/LC\/C2LC21019C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:20:52Z","timestamp":1782879652000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/lc\/article\/12\/7\/1320-1326\/375923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":53,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1039\/c2lc21019c","relation":{},"ISSN":["1473-0197","1473-0189"],"issn-type":[{"value":"1473-0197","type":"print"},{"value":"1473-0189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}