{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T09:22:09Z","timestamp":1769764929951,"version":"3.49.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2012,2,6]],"date-time":"2012-02-06T00:00:00Z","timestamp":1328486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,2,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Determining interacting cellular partners of drugs by chemical proteomic techniques is complex and tedious. Most approaches rely on activity-based probe profiling and compound-centric chemical proteomics. The anti-malarial artemisinin also exerts profound anti-cancer activity, but the mechanisms of action are incompletely understood. In the present investigation, we present a novel approach to identify artemisinin-interacting target proteins. Our approach overcomes usual problems in traditional fishing procedures, because the drug was attached to a surface without further chemical modification. The proteins identified effect among others, cell cycle arrest, apoptosis, inhibition of angiogenesis, disruption of cell migration, and modulation of nuclear receptor responsiveness. Furthermore, a bioinformatic approach confirmed experimentally identified proteins and suggested a large number of other interacting proteins. Theoretically predicted interaction partners may serve as a starting point to complete the whole set of proteins binding artemisinin.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/c2mb05437j","type":"journal-article","created":{"date-parts":[[2012,2,6]],"date-time":"2012-02-06T09:00:45Z","timestamp":1328518845000},"page":"1311-1318","source":"Crossref","is-referenced-by-count":18,"title":["Bioinformatic and experimental fishing for artemisinin-interacting proteins from human nasopharyngeal cancer cells"],"prefix":"10.1093","volume":"8","author":[{"given":"T","family":"Eichhorn","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University of Mainz a , Staudinger Weg 5, 55128 Mainz Germany \u00a0 efferth@uni-mainz.de \u00a0 +49-6131-39-23752 \u00a0 +49-6131-39-25751"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Schloissnig","sequence":"additional","affiliation":[{"name":"Max Planck Institute (MPI) for Molecular Cell Biology and Genetics b , Pfotenhauerstrasse 108, D-01307 Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Hahn","sequence":"additional","affiliation":[{"name":"German Cancer Research Center (DKFZ), Molecular Structure Analysis (W160) c , Im Neuenheimer Feld 280, 69120 Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Wendler","sequence":"additional","affiliation":[{"name":"Biochemistry Center, University of Heidelberg d , Im Neuenheimer Feld 504, 69120 Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Mertens","sequence":"additional","affiliation":[{"name":"Department for Pediatrics, University Hospital Aachen e , Pauwelsstra\u00dfe 30, 52074 Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W D","family":"Lehmann","sequence":"additional","affiliation":[{"name":"German Cancer Research Center (DKFZ), Molecular Structure Analysis (W160) c , Im Neuenheimer Feld 280, 69120 Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R L","family":"Krauth-Siegel","sequence":"additional","affiliation":[{"name":"Biochemistry Center, University of Heidelberg d , Im Neuenheimer Feld 504, 69120 Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Efferth","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University of Mainz a , Staudinger Weg 5, 55128 Mainz Germany \u00a0 efferth@uni-mainz.de \u00a0 +49-6131-39-23752 \u00a0 +49-6131-39-25751"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,2,6]]},"reference":[{"key":"2026012913045837500_cit1","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1126\/science.1132939","article-title":"The connectivity map: using gene expression signatures to connect small molecules, genes and disease","volume":"313","author":"Lamb","year":"2006","journal-title":"Science"},{"key":"2026012913045837500_cit2","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nchembio1206-663","article-title":"The connectivity map","volume":"2","author":"Mishnick","year":"2006","journal-title":"Nat. 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