{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:59:21Z","timestamp":1790974761902,"version":"4.1.0"},"reference-count":35,"publisher":"Royal Society of Chemistry (RSC)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Org. Biomol. Chem."],"published-print":{"date-parts":[[2012]]},"DOI":"10.1039\/c2ob06987c","type":"journal-article","created":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T06:30:33Z","timestamp":1326090633000},"page":"2923","source":"Crossref","is-referenced-by-count":22,"title":["Synthesis of N-substituted \u03b5-hexonolactams as pharmacological chaperones for the treatment of N370S mutant Gaucher disease"],"prefix":"10.1039","volume":"10","author":[{"given":"Guan-Nan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Twigg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry D.","family":"Butters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangren","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-He","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Shan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","reference":[{"key":"c2ob06987c-(cit1)\/*[position()=1]","first-page":"377","volume":"21","author":"Grabowski","year":"1993","journal-title":"Adv. Hum. Genet."},{"key":"c2ob06987c-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5384","DOI":"10.1073\/pnas.90.12.5384","volume":"90","author":"Beutler","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"c2ob06987c-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1007\/s00018-002-8458-y","volume":"59","author":"Zhao","year":"2002","journal-title":"Cell. Mol. Life Sci."},{"key":"c2ob06987c-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1097\/MOP.0b013e3282f161f2","volume":"19","author":"Burrow","year":"2007","journal-title":"Curr. Opin. Pediatr."},{"key":"c2ob06987c-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1358\/dof.2003.028.03.723080","volume":"28","author":"Sorbera","year":"2003","journal-title":"Drugs Future"},{"key":"c2ob06987c-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1042\/bj20030348","volume":"374","author":"Mellor","year":"2003","journal-title":"Biochem. J."},{"key":"c2ob06987c-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0165-6147(03)00158-5","volume":"24","author":"Fan","year":"2003","journal-title":"Trends Pharmacol. Sci."},{"key":"c2ob06987c-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nchembio850","volume":"3","author":"Lieberman","year":"2007","journal-title":"Nat. Chem. Biol."},{"key":"c2ob06987c-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.chembiol.2005.09.007","volume":"12","author":"Sawkar","year":"2005","journal-title":"Chem. Biol."},{"key":"c2ob06987c-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4082","DOI":"10.1111\/j.1742-4658.2006.05410.x","volume":"273","author":"Chang","year":"2006","journal-title":"FEBS J."},{"key":"c2ob06987c-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/humu.10212","volume":"21","author":"Stenson","year":"2003","journal-title":"Hum. Mutat."},{"key":"c2ob06987c-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1182\/blood.V79.7.1662.bloodjournal7971662","volume":"79","author":"Beutler","year":"1992","journal-title":"Blood"},{"key":"c2ob06987c-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1365-2141.1993.tb03185.x","volume":"85","author":"Beutler","year":"1993","journal-title":"Br. J. Haematol."},{"key":"c2ob06987c-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4242","DOI":"10.1074\/jbc.M511110200","volume":"281","author":"Liou","year":"2006","journal-title":"J. Biol. Chem."},{"key":"c2ob06987c-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s00018-005-5437-0","volume":"63","author":"Sawkar","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"c2ob06987c-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"15428","DOI":"10.1073\/pnas.192582899","volume":"99","author":"Sawkar","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"c2ob06987c-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1002\/cbic.200600217","volume":"7","author":"Compain","year":"2006","journal-title":"ChemBioChem"},{"key":"c2ob06987c-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7450","DOI":"10.1002\/anie.200502662","volume":"44","author":"Zhu","year":"2005","journal-title":"Angew. Chem., Int. Ed."},{"key":"c2ob06987c-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1021\/jm060677i","volume":"50","author":"Yu","year":"2007","journal-title":"J. Med. Chem."},{"key":"c2ob06987c-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1021\/jm801506m","volume":"52","author":"Wang","year":"2009","journal-title":"J. Med. Chem."},{"key":"c2ob06987c-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1039\/a809807g","author":"Long","year":"1999","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"c2ob06987c-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7757","DOI":"10.1021\/jo201125x","volume":"76","author":"Diot","year":"2011","journal-title":"J. Org. Chem."},{"key":"c2ob06987c-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0008-6215(00)85498-1","volume":"73","author":"Eby","year":"1979","journal-title":"Carbohydr. Res."},{"key":"c2ob06987c-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9183","DOI":"10.1016\/j.tet.2006.07.032","volume":"62","author":"Namme","year":"2006","journal-title":"Tetrahedron"},{"key":"c2ob06987c-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1021\/jo1020322","volume":"76","author":"Wang","year":"2011","journal-title":"J. Org. Chem."},{"key":"c2ob06987c-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1021\/ml2000998","volume":"2","author":"Wang","year":"2011","journal-title":"ACS Med. Chem. Lett."},{"key":"c2ob06987c-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7647","DOI":"10.1021\/ja960975c","volume":"118","author":"Moris-Varas","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"c2ob06987c-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/S0040-4020(03)00177-7","volume":"59","author":"Tilekar","year":"2003","journal-title":"Tetrahedron"},{"key":"c2ob06987c-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1039\/B610377D","author":"Li","year":"2007","journal-title":"Chem. Commun."},{"key":"c2ob06987c-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.bcmd.2005.05.007","volume":"35","author":"Alfonso","year":"2005","journal-title":"Blood Cells, Mol., Dis."},{"key":"c2ob06987c-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1023\/B:BOLI.0000042959.44318.7c","volume":"27","author":"Schueler","year":"2004","journal-title":"J. Inherited Metab. Dis."},{"key":"c2ob06987c-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/BF03401556","volume":"1","author":"Beutler","year":"1995","journal-title":"Mol. Med. (Tokyo)"},{"key":"c2ob06987c-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1135\/cccc19892156","volume":"54","author":"Kefurt","year":"1989","journal-title":"Collect. Czech. Chem. Commun."},{"key":"c2ob06987c-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0022-2860(98)00856-4","volume":"482","author":"Havlicek","year":"1999","journal-title":"J. Mol. Struct."},{"key":"c2ob06987c-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"29052","DOI":"10.1074\/jbc.M705005200","volume":"282","author":"Brumshtein","year":"2007","journal-title":"J. Biol. Chem."}],"container-title":["Organic & Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2012\/OB\/C2OB06987C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:53:56Z","timestamp":1782964436000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/10\/15\/2923-2927\/379515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":35,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1039\/c2ob06987c","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}