{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:16:05Z","timestamp":1791494165112,"version":"4.3.4"},"reference-count":50,"publisher":"Royal Society of Chemistry (RSC)","issue":"46","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Org. Biomol. Chem."],"abstract":"<jats:p>KF-mediated nucleophilic activation of TMSCN as a functional isonitrile equivalent establishes an efficient and chemoselective Ugi-type multicomponent reaction of a heterocyclic amidine and aldehyde with TMSCN in water.<\/jats:p>","DOI":"10.1039\/c2ob26733k","type":"journal-article","created":{"date-parts":[[2012,10,3]],"date-time":"2012-10-03T04:37:30Z","timestamp":1349239050000},"page":"9271-9277","source":"Crossref","is-referenced-by-count":45,"title":["A chemoselective Ugi-type reaction in water using TMSCN as a functional isonitrile equivalent: generation of heteroaromatic molecular diversity"],"prefix":"10.1039","volume":"10","author":[{"given":"Sankar Kumar","family":"Guchhait","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), S. A. S. Nagar, Mohali - 160062, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), S. A. S. Nagar, Mohali - 160062, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetna","family":"Madaan","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), S. A. S. Nagar, Mohali - 160062, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2012]]},"reference":[{"key":"C2OB26733K\/cit1a\/1","doi-asserted-by":"crossref","first-page":"17272","DOI":"10.1073\/pnas.0503647102","volume":"102","author":"Koch","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C2OB26733K\/cit1b\/1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.drudis.2010.11.014","volume":"16","author":"Ritchie","year":"2011","journal-title":"Drug Discovery Today"},{"key":"C2OB26733K\/cit1c\/1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1039\/c0md00020e","volume":"1","author":"Reymond","year":"2010","journal-title":"Med. Chem. Commun."},{"key":"C2OB26733K\/cit1d\/1","doi-asserted-by":"crossref","first-page":"4568","DOI":"10.1021\/jm060217p","volume":"49","author":"Ertl","year":"2006","journal-title":"J. Med. Chem."},{"key":"C2OB26733K\/cit2a\/1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1021\/cr0505728","volume":"106","author":"D\u00f6mling","year":"2006","journal-title":"Chem. Rev."},{"key":"C2OB26733K\/cit2b\/1","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1021\/cr800296p","volume":"109","author":"Tour\u00e9","year":"2009","journal-title":"Chem. Rev."},{"key":"C2OB26733K\/cit2c\/1","doi-asserted-by":"crossref","first-page":"6234","DOI":"10.1002\/anie.201006515","volume":"50","author":"Ruijter","year":"2011","journal-title":"Angew. Chem., Int. Ed."},{"key":"C2OB26733K\/cit2d\/1","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1002\/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO;2-U","volume":"39","author":"Balme","year":"2000","journal-title":"Angew. Chem., Int. Ed."},{"key":"C2OB26733K\/cit2e\/1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.cbpa.2008.02.004","volume":"12","author":"Akritopoulou-Zanze","year":"2008","journal-title":"Curr. Opin. Chem. Biol."},{"key":"C2OB26733K\/cit3a\/1","doi-asserted-by":"crossref","first-page":"9418","DOI":"10.1002\/anie.201103567","volume":"50","author":"Santra","year":"2011","journal-title":"Angew. Chem., Int. Ed."},{"key":"C2OB26733K\/cit3b\/1","doi-asserted-by":"crossref","first-page":"5352","DOI":"10.1002\/anie.201001343","volume":"49","author":"Czarna","year":"2010","journal-title":"Angew. Chem., Int. Ed."},{"key":"C2OB26733K\/cit3c\/1","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1039\/b927388c","volume":"46","author":"Brauch","year":"2010","journal-title":"Chem. Commun."},{"key":"C2OB26733K\/cit3d\/1","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1021\/jo102305q","volume":"76","author":"Santra","year":"2011","journal-title":"J. Org. Chem."},{"key":"C2OB26733K\/cit3e\/1","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1021\/ol1020477","volume":"12","author":"Che","year":"2010","journal-title":"Org. Lett."},{"key":"C2OB26733K\/cit3f\/1","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1021\/ol100931q","volume":"12","author":"Ramazani","year":"2010","journal-title":"Org. Lett."},{"key":"C2OB26733K\/cit3g\/1","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.1021\/ol101590w","volume":"12","author":"Borisov","year":"2010","journal-title":"Org. Lett."},{"key":"C2OB26733K\/cit4a\/1","doi-asserted-by":"crossref","first-page":"12296","DOI":"10.1002\/chem.201002046","volume":"16","author":"Cao","year":"2010","journal-title":"Chem.\u2013Eur. J."},{"key":"C2OB26733K\/cit4b\/1","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1002\/anie.200907291","volume":"49","author":"Chernyak","year":"2010","journal-title":"Angew. Chem., Int. Ed."},{"key":"C2OB26733K\/cit5a\/1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2174\/0929867033368600","volume":"10","author":"Hulme","year":"2003","journal-title":"Curr. Med. Chem."},{"key":"C2OB26733K\/cit5b\/1","doi-asserted-by":"crossref","first-page":"10770","DOI":"10.1039\/c1cc10759c","volume":"47","author":"Cano-Herrera","year":"2011","journal-title":"Chem. Commun."},{"key":"C2OB26733K\/cit5c\/1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1747-0285.2010.00990.x","volume":"76","author":"Huang","year":"2010","journal-title":"Chem. Biol. Drug Des."},{"key":"C2OB26733K\/cit5d\/1","doi-asserted-by":"crossref","first-page":"5343","DOI":"10.1021\/jo100759b","volume":"75","author":"Ka\u00efm","year":"2010","journal-title":"J. Org. Chem."},{"key":"C2OB26733K\/cit5e\/1","doi-asserted-by":"crossref","first-page":"4236","DOI":"10.1039\/b613056a","volume":"4","author":"Banfi","year":"2006","journal-title":"Org. Biomol. Chem."},{"key":"C2OB26733K\/cit6a\/1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1055\/s-1998-1721","author":"Groebke","year":"1998","journal-title":"Synlett"},{"key":"C2OB26733K\/cit6b\/1","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1016\/S0040-4039(98)00653-4","volume":"39","author":"Blackburn","year":"1998","journal-title":"Tetrahedron Lett."},{"key":"C2OB26733K\/cit6c\/1","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1002\/(SICI)1521-3773(19980904)37:16<2234::AID-ANIE2234>3.0.CO;2-R","volume":"37","author":"Bienayme","year":"1998","journal-title":"Angew. Chem., Int. Ed."},{"key":"C2OB26733K\/cit7a\/1","doi-asserted-by":"crossref","first-page":"4438","DOI":"10.1021\/jo3003024","volume":"77","author":"Guchhait","year":"2012","journal-title":"J. Org. Chem."},{"key":"C2OB26733K\/cit7b\/1","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1055\/s-0028-1087915","author":"Guchhait","year":"2009","journal-title":"Synlett"},{"key":"C2OB26733K\/cit7c\/1","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1055\/s-0029-1216916","author":"Guchhait","year":"2009","journal-title":"Synthesis"},{"key":"C2OB26733K\/cit7d\/1","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1039\/c0ob00022a","volume":"8","author":"Guchhait","year":"2010","journal-title":"Org. Biomol. Chem."},{"key":"C2OB26733K\/cit7e\/1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.tetlet.2010.10.143","volume":"52","author":"Guchhait","year":"2011","journal-title":"Tetrahedron Lett."},{"key":"C2OB26733K\/cit7f\/1","doi-asserted-by":"crossref","first-page":"5013","DOI":"10.1021\/jm200235u","volume":"54","author":"Baviskar","year":"2011","journal-title":"J. Med. Chem."},{"key":"C2OB26733K\/cit8a\/1","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1021\/jo202255v","volume":"77","author":"Tyagi","year":"2012","journal-title":"J. Org. Chem."},{"key":"C2OB26733K\/cit8b\/1","doi-asserted-by":"crossref","first-page":"5990","DOI":"10.1016\/j.tetlet.2008.07.177","volume":"49","author":"Sandulenko","year":"2008","journal-title":"Tetrahedron Lett."},{"key":"C2OB26733K\/cit9\/1","doi-asserted-by":"crossref","first-page":"11772","DOI":"10.1021\/ja0644374","volume":"128","author":"Pirrung","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"C2OB26733K\/cit10a\/1","doi-asserted-by":"crossref","first-page":"8355","DOI":"10.1016\/j.tetlet.2005.09.181","volume":"46","author":"Schwerkoske","year":"2005","journal-title":"Tetrahedron Lett."},{"key":"C2OB26733K\/cit10b\/1","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1016\/j.tetlet.2006.01.160","volume":"47","author":"Masquelin","year":"2006","journal-title":"Tetrahedron Lett."},{"key":"C2OB26733K\/cit10c\/1","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1016\/j.tetlet.2009.05.080","volume":"50","author":"Polyakov","year":"2009","journal-title":"Tetrahedron Lett."},{"key":"C2OB26733K\/cit10d\/1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00706-011-0655-7","volume":"143","author":"Sadjadi","year":"2011","journal-title":"Monatsh. Chem."},{"key":"C2OB26733K\/cit11\/1","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1039\/C1CS15222J","volume":"41","author":"Simon","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"C2OB26733K\/cit12a\/1","doi-asserted-by":"crossref","first-page":"3922","DOI":"10.1016\/j.tetlet.2010.05.088","volume":"51","author":"Li","year":"2010","journal-title":"Tetrahedron Lett."},{"key":"C2OB26733K\/cit12b\/1","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1016\/j.tetlet.2010.04.123","volume":"51","author":"Aoki","year":"2010","journal-title":"Tetrahedron Lett."},{"key":"C2OB26733K\/cit12c\/1","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.1016\/j.tetlet.2006.06.008","volume":"47","author":"Paraskar","year":"2006","journal-title":"Tetrahedron Lett."},{"key":"C2OB26733K\/cit12d\/1","doi-asserted-by":"crossref","first-page":"5881","DOI":"10.1016\/j.tetlet.2005.06.128","volume":"46","author":"Iwanami","year":"2005","journal-title":"Tetrahedron Lett."},{"key":"C2OB26733K\/cit13\/1","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1021\/cc070058a","volume":"9","author":"Che","year":"2007","journal-title":"J. Comb. Chem."},{"key":"C2OB26733K\/cit14a\/1","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1021\/jm051252j","volume":"49","author":"Paulis","year":"2006","journal-title":"J. Med. Chem."},{"key":"C2OB26733K\/cit14b\/1","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.1002\/anie.200800497","volume":"47","author":"Surryand","year":"2008","journal-title":"Angew. Chem., Int. Ed."},{"key":"C2OB26733K\/cit14c\/1","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1016\/j.tetlet.2009.05.080","volume":"50","author":"Polyakov","year":"2009","journal-title":"Tetrahedron Lett."},{"key":"C2OB26733K\/cit14d\/1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/jhet.5570240303","volume":"24","author":"Paolini","year":"1987","journal-title":"J. Heterocycl. Chem."},{"key":"C2OB26733K\/cit14e\/1","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.3987\/COM-95-7126","volume":"41","author":"Chavignon","year":"1995","journal-title":"Heterocycles"}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2012\/OB\/C2OB26733K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:49:16Z","timestamp":1782884956000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/10\/46\/9271-9277\/1235071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":50,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2012,11,7]]}},"URL":"https:\/\/doi.org\/10.1039\/c2ob26733k","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}